iPTMnet Report for Q9UBN7 (HDAC6)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9UBN7 / HDAC6_HUMAN
Protein Name Histone deacetylase 6
Gene Name Name: HDAC6
Synonyms:KIAA0901;ORFNames:JM21;
Organism Homo sapiens (Human)

PRO ID PR:Q9UBN7
DAG View
PRO Name histone deacetylase 6 (human)
Definition A histone deacetylase 6 that is encoded in the genome of human.
Short Label hHDAC6
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9UBN7 (HDAC6) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S16 Phosphorylation PhosphoSitePlus
S22 O-Glycosylation GlyGen 23301498, 36240223, 30796923
S22 Phosphorylation phospho.ELM   PhosphoSitePlus   RLIMS-P+   RLIMS-P   UniProt 30443180, 23186163, 16964243, ...20520769, 15302935, 30909412
S22 Phosphorylation P49841 (GSK3B) RLIMS-P+ 20520769
S28 Phosphorylation PhosphoSitePlus
T30 Phosphorylation phospho.ELM   PhosphoSitePlus 17287340
K32 Ubiquitination PhosphoSitePlus
K36 Acetylation PhosphoSitePlus
K37 Acetylation PhosphoSitePlus
S43 Phosphorylation PhosphoSitePlus
K51 Ubiquitination PhosphoSitePlus
K116 Ubiquitination PhosphoSitePlus
S146 Phosphorylation PhosphoSitePlus
Y319 Phosphorylation PhosphoSitePlus
S412 Phosphorylation PhosphoSitePlus   RLIMS-P 30443180
S458 Phosphorylation PhosphoSitePlus   RLIMS-P 21486957, 22896792
S458 Phosphorylation P68400 (CSNK2A1) PhosphoSitePlus 21486957
Y570 Phosphorylation neXtProt   PhosphoSitePlus   RLIMS-P   Signor 20029029
Y570 Phosphorylation P00533 (EGFR) neXtProt   PhosphoSitePlus   Signor 20029029
T678 Phosphorylation PhosphoSitePlus
S846 Phosphorylation PhosphoSitePlus
S847 Phosphorylation PhosphoSitePlus
K849 Acetylation PhosphoSitePlus
K849 Ubiquitination PhosphoSitePlus
K853 Acetylation PhosphoSitePlus
K854 Acetylation PhosphoSitePlus
K854 Ubiquitination PhosphoSitePlus
K860 Ubiquitination PhosphoSitePlus
T868 Phosphorylation PhosphoSitePlus
K873 Acetylation PhosphoSitePlus
K881 Acetylation PhosphoSitePlus
T923 Phosphorylation PhosphoSitePlus
S925 Phosphorylation PhosphoSitePlus
T993 Phosphorylation PhosphoSitePlus
S995 Phosphorylation PhosphoSitePlus
T1003 Phosphorylation PhosphoSitePlus
T1016 Phosphorylation PhosphoSitePlus   UniProt 24275569
T1021 Phosphorylation PhosphoSitePlus   UniProt 24275569
T1027 Phosphorylation PhosphoSitePlus   UniProt 24275569
T1031 Phosphorylation PhosphoSitePlus   Signor   UniProt 24089523, 24275569
T1031 Phosphorylation P27361 (MAPK3) PhosphoSitePlus   Signor 24089523
T1031 Phosphorylation P28482 (MAPK1) PhosphoSitePlus 24089523
T1034 Phosphorylation PhosphoSitePlus   UniProt 24275569
S1035 Phosphorylation PhosphoSitePlus   Signor   UniProt 24089523, 24275569
S1035 Phosphorylation P27361 (MAPK3) PhosphoSitePlus   Signor 24089523
T1040 Phosphorylation PhosphoSitePlus   UniProt 24275569
T1041 Phosphorylation PhosphoSitePlus
T1048 Phosphorylation PhosphoSitePlus
T1055 Phosphorylation PhosphoSitePlus
S1062 Phosphorylation PhosphoSitePlus
K1206 Ubiquitination PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S22 Phosphorylation HPRD 15302935, 16964243
T30 Phosphorylation HPRD 17287340


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K36 R36 Biomuta DOID:3571 / liver cancer [ cosmic, icgc ]
S412 L412 Biomuta DOID:4159 / skin cancer [ cosmic ]
Y570 S570 Biomuta DOID:4159 / skin cancer [ cosmic ]
S846 T846 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
K853 N853 Biomuta DOID:363 / uterine cancer [ icgc ]
K881 T881 Biomuta DOID:363 / uterine cancer [ icgc ]
S925 Y925 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
T993 S993 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
S995 L995 Biomuta DOID:4362 / cervical cancer [ cosmic, icgc ] DOID:9256 / colorectal cancer [ cosmic ]
T1016 N1016 Biomuta DOID:1612 / breast cancer [ cosmic ]
S1035 L1035 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
T1040 P1040 Biomuta DOID:2531 / hematologic cancer [ cosmic ]