iPTMnet Report for Q9UBL0 (ARPP21)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9UBL0 / ARP21_HUMAN
Protein Name cAMP-regulated phosphoprotein 21
Gene Name Name: ARPP21
Synonyms:TARPP;
Organism Homo sapiens (Human)

PRO ID PR:Q9UBL0
DAG View
PRO Name cAMP-regulated phosphoprotein 21 (human)
Definition A cAMP-regulated phosphoprotein 21 that is encoded in the genome of human.
Short Label hARPP21
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9UBL0 (ARPP21) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S33 Phosphorylation PhosphoSitePlus   UniProt 19690332
K39 Ubiquitination PhosphoSitePlus
K57 Acetylation PhosphoSitePlus
S58 Phosphorylation P17612 (PRKACA) neXtProt   PhosphoSitePlus 10854908
K62 Acetylation PhosphoSitePlus
K64 Acetylation PhosphoSitePlus
S68 Phosphorylation PhosphoSitePlus
S134 Phosphorylation PhosphoSitePlus
S138 Phosphorylation PhosphoSitePlus
Y141 Phosphorylation PhosphoSitePlus
T156 Phosphorylation PhosphoSitePlus
K158 Ubiquitination PhosphoSitePlus
K186 Ubiquitination PhosphoSitePlus
K187 Ubiquitination PhosphoSitePlus
T215 Phosphorylation PhosphoSitePlus
K217 Ubiquitination PhosphoSitePlus
S218 Phosphorylation PhosphoSitePlus
K223 Ubiquitination PhosphoSitePlus
S257 Phosphorylation PhosphoSitePlus
S278 Phosphorylation PhosphoSitePlus
S280 Phosphorylation PhosphoSitePlus
R284 Methylation PhosphoSitePlus
Y288 Phosphorylation PhosphoSitePlus
K326 Ubiquitination PhosphoSitePlus
S338 Phosphorylation PhosphoSitePlus
S363 Phosphorylation PhosphoSitePlus
S364 Phosphorylation PhosphoSitePlus
S367 Phosphorylation PhosphoSitePlus
K375 Ubiquitination PhosphoSitePlus
T381 Phosphorylation PhosphoSitePlus
S383 Phosphorylation PhosphoSitePlus   UniProt 19690332
S395 Phosphorylation PhosphoSitePlus
S410 Phosphorylation PhosphoSitePlus
S414 Phosphorylation PhosphoSitePlus
S418 Phosphorylation PhosphoSitePlus
S421 Phosphorylation PhosphoSitePlus
S562 Phosphorylation PhosphoSitePlus   UniProt 19690332
R655 Methylation PhosphoSitePlus   UniProt 15096520
Site PTM Type PTM Enzyme Score Source PMID
S280 Phosphorylation HPRD 19651622
T381 Phosphorylation HPRD 15144186
S383 Phosphorylation HPRD 15144186
Site PTM Type PTM Enzyme Score Source PMID
S83 Phosphorylation PhosphoSitePlus
T88 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S33 G33 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S83 C83 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
S83 G83 Biomuta DOID:3571 / liver cancer [ cosmic ]
S134 * Biomuta DOID:9256 / colorectal cancer [ cosmic ] DOID:11054 / urinary bladder cancer [ cosmic ]
S138 N138 Biomuta DOID:363 / uterine cancer [ icgc ]
S138 R138 Biomuta DOID:10534 / stomach cancer [ cosmic ]
T156 I156 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
K158 N158 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
T215 K215 Biomuta DOID:4159 / skin cancer [ cosmic ]
S278 N278 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
R284 T284 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
K326 M326 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
K326 N326 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]
S338 L338 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S363 R363 Biomuta DOID:10534 / stomach cancer [ cosmic ]
S364 R364 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S367 A367 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
T381 M381 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ] DOID:10283 / prostate cancer [ cosmic, icgc ]
S383 R383 Biomuta DOID:4159 / skin cancer [ cosmic ]
S383 G383 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
S410 Y410 Biomuta DOID:1324 / lung cancer [ cosmic ]
S421 L421 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ] DOID:10283 / prostate cancer [ cosmic ]
S562 R562 Biomuta DOID:1324 / lung cancer [ cosmic ]
R655 W655 Biomuta DOID:4362 / cervical cancer [ cosmic, icgc ] DOID:10283 / prostate cancer [ cosmic ]
R655 Q655 Biomuta DOID:9256 / colorectal cancer [ cosmic ] DOID:2531 / hematologic cancer [ cosmic ]