iPTMnet Report for Q9UBF8 (PI4KB)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9UBF8 / PI4KB_HUMAN
Protein Name Phosphatidylinositol 4-kinase beta
Gene Name Name: PI4KB
Synonyms:PIK4CB;
Organism Homo sapiens (Human)

PRO ID PR:Q9UBF8
DAG View
PRO Name phosphatidylinositol 4-kinase beta (human)
Definition A phosphatidylinositol 4-kinase beta that is encoded in the genome of human.
Short Label hPI4KB
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9UBF8 (PI4KB) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
G2 Acetylation UniProt 23572552
K60 Ubiquitination PhosphoSitePlus
Y147 Phosphorylation PhosphoSitePlus
Y175 Phosphorylation PhosphoSitePlus
Y183 Phosphorylation PhosphoSitePlus
S205 Phosphorylation PhosphoSitePlus
S209 Phosphorylation PhosphoSitePlus
S256 Phosphorylation PhosphoSitePlus
S258 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 11277933, ...20068231
T263 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 11277933
S266 Phosphorylation P06493 (CDK1) phospho.ELM   PhosphoSitePlus   UniProt 23186163, 18220336, 18234856, ...11277933, 20068231
S268 Phosphorylation PhosphoSitePlus
S275 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S277 Phosphorylation Q15208 (STK38) neXtProt   phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 11277933, ...22445341
T280 Phosphorylation PhosphoSitePlus
S286 Phosphorylation PhosphoSitePlus
S287 Phosphorylation HPRD 17322306, 18767875, 18669648
K290 Methylation PhosphoSitePlus
T292 Phosphorylation HPRD 19413330
S294 Phosphorylation Q15139 (PRKD1) , Q9BZL6 (PRKD2) HPRD   neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 18767875, 16912074, 18669648, ...23572552, 16606619, 11277933, 16100512
S306 Phosphorylation HPRD 11277933
K337 Ubiquitination PhosphoSitePlus
T341 Phosphorylation PhosphoSitePlus
K345 Ubiquitination PhosphoSitePlus
T349 Phosphorylation PhosphoSitePlus
K362 Ubiquitination PhosphoSitePlus
K392 Ubiquitination PhosphoSitePlus
S425 Phosphorylation PhosphoSitePlus
T426 Phosphorylation PhosphoSitePlus
S428 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 23186163, 17081983, ...18220336, 18669648, 19690332, 20068231
T438 Phosphorylation UniProt 11277933
S511 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 23186163, 17081983, 18220336, ...18669648, 11277933
T517 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 18220336
T519 Phosphorylation PhosphoSitePlus   UniProt 11277933
K534 Ubiquitination PhosphoSitePlus
C565 Methylation IEDB 31844290
K596 Ubiquitination PhosphoSitePlus
K742 Acetylation PhosphoSitePlus
Y805 Phosphorylation PhosphoSitePlus
Y810 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S258 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
T263 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S266 Phosphorylation phospho.ELM   PhosphoSitePlus 18220336
S275 Phosphorylation phospho.ELM 18669648
S277 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
T292 Phosphorylation PhosphoSitePlus
S294 Phosphorylation Q15139 (PRKD1) , Q9BZL6 (PRKD2) PhosphoSitePlus 16912074, 16100512
S398 Phosphorylation phospho.ELM 18669648, 18220336
T423 Phosphorylation PhosphoSitePlus
S496 Phosphorylation PhosphoSitePlus
T504 Phosphorylation PhosphoSitePlus
K727 Acetylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
Y147 C147 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]
S209 F209 Biomuta DOID:4159 / skin cancer [ cosmic ] DOID:3571 / liver cancer [ cosmic ]
S256 P256 Biomuta DOID:3571 / liver cancer [ cosmic ]
S256 T256 Biomuta DOID:10534 / stomach cancer [ cosmic ]
S266 F266 Biomuta DOID:4159 / skin cancer [ cosmic ]
S294 I294 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S306 F306 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
K337 Q337 Biomuta DOID:4159 / skin cancer [ cosmic ]
T341 M341 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
C565 W565 Biomuta DOID:1612 / breast cancer [ cosmic ]
Y810 * Biomuta DOID:4159 / skin cancer [ cosmic ] DOID:363 / uterine cancer [ cosmic, icgc ] DOID:3571 / liver cancer [ cosmic ]