iPTMnet Report for Q9P2P5 (HECW2)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9P2P5 / HECW2_HUMAN
Protein Name E3 ubiquitin-protein ligase HECW2
Gene Name Name: HECW2
Synonyms:KIAA1301,NEDL2;
Organism Homo sapiens (Human)

PRO ID PR:Q9P2P5
DAG View
PRO Name E3 ubiquitin-protein ligase HECW2 (human)
Definition An E3 ubiquitin-protein ligase HECW2 that is encoded in the genome of human.
Short Label hHECW2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9P2P5 (HECW2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S3 Phosphorylation PhosphoSitePlus
S4 Phosphorylation PhosphoSitePlus
S24 Phosphorylation PhosphoSitePlus
S48 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163
T50 Phosphorylation PhosphoSitePlus
C156 Methylation IEDB 31844290
K183 Ubiquitination PhosphoSitePlus
K198 Ubiquitination PhosphoSitePlus
K199 Methylation PhosphoSitePlus
Y208 Phosphorylation PhosphoSitePlus
K210 Ubiquitination PhosphoSitePlus
K218 Ubiquitination PhosphoSitePlus
S220 Phosphorylation PhosphoSitePlus
S390 Phosphorylation PhosphoSitePlus
T396 Phosphorylation PhosphoSitePlus
S444 Phosphorylation PhosphoSitePlus
T453 Phosphorylation PhosphoSitePlus
S465 Phosphorylation PhosphoSitePlus
C660 Methylation IEDB 31844290
S742 Phosphorylation PhosphoSitePlus
S850 Phosphorylation PhosphoSitePlus
S852 Phosphorylation PhosphoSitePlus   UniProt 23186163
S865 Phosphorylation PhosphoSitePlus
S909 Phosphorylation PhosphoSitePlus   UniProt 23186163
S1027 Phosphorylation PhosphoSitePlus
S1040 Phosphorylation PhosphoSitePlus
S1042 Phosphorylation PhosphoSitePlus
T1064 Phosphorylation PhosphoSitePlus
S1171 Phosphorylation PhosphoSitePlus
S1175 Phosphorylation PhosphoSitePlus   UniProt 24275569
S1237 Phosphorylation PhosphoSitePlus
T1398 Phosphorylation PhosphoSitePlus
S1439 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S48 Phosphorylation HPRD 19413330, 19651622, 18669648, ...19664994
S852 Phosphorylation HPRD 19413330
T1064 Phosphorylation HPRD 19651622


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S3 N3 Biomuta DOID:1612 / breast cancer [ cosmic ]
S4 L4 Biomuta DOID:4159 / skin cancer [ cosmic ]
S24 C24 Biomuta DOID:1612 / breast cancer [ cosmic ]
S24 I24 Biomuta DOID:3571 / liver cancer [ cosmic ]
K210 N210 Biomuta DOID:1324 / lung cancer [ cosmic ]
S390 F390 Biomuta DOID:4159 / skin cancer [ cosmic ]
S465 * Biomuta DOID:1324 / lung cancer [ cosmic ]
C660 * Biomuta DOID:263 / kidney cancer [ cosmic ]
S742 N742 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S852 F852 Biomuta [ cosmic ]
S909 F909 Biomuta DOID:11054 / urinary bladder cancer [ cosmic ]
S1040 R1040 Biomuta DOID:5041 / esophageal cancer [ cosmic ]
S1171 F1171 Biomuta DOID:4159 / skin cancer [ cosmic ]
S1439 C1439 Biomuta DOID:1319 / brain cancer [ cosmic ]
S1439 T1439 Biomuta DOID:4159 / skin cancer [ cosmic ]