iPTMnet Report for Q9P2K8 (EIF2AK4)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9P2K8 / E2AK4_HUMAN
Protein Name eIF-2-alpha kinase GCN2
Gene Name Name: EIF2AK4
Synonyms:GCN2,KIAA1338;
Organism Homo sapiens (Human)

PRO ID PR:Q9P2K8
DAG View
PRO Name eIF-2-alpha kinase GCN2 (human)
Definition An eIF-2-alpha kinase GCN2 that is encoded in the genome of human.
Short Label hEIF2AK4
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9P2K8 (EIF2AK4) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
R5 Methylation PhosphoSitePlus
S102 Phosphorylation PhosphoSitePlus
S205 Phosphorylation PhosphoSitePlus
S207 Phosphorylation PhosphoSitePlus
S230 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18691976, 21406692, 23186163, ...18669648, 20068231
Y253 Phosphorylation PhosphoSitePlus
S254 Phosphorylation PhosphoSitePlus
S261 Phosphorylation PhosphoSitePlus
Y269 Phosphorylation PhosphoSitePlus
S467 Phosphorylation PhosphoSitePlus
K474 Ubiquitination PhosphoSitePlus
Y500 Phosphorylation PhosphoSitePlus
S551 Phosphorylation PhosphoSitePlus
S555 Phosphorylation PhosphoSitePlus
Y560 Phosphorylation PhosphoSitePlus
S572 Phosphorylation PhosphoSitePlus
K606 Acetylation PhosphoSitePlus
K610 Ubiquitination PhosphoSitePlus
K619 Ubiquitination PhosphoSitePlus
K634 Ubiquitination PhosphoSitePlus
T667 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18691976, 23186163, 17081983, ...19369195, 17192257, 20068231
S672 Phosphorylation PhosphoSitePlus
S770 Phosphorylation PhosphoSitePlus
K850 Ubiquitination PhosphoSitePlus
T871 Phosphorylation PhosphoSitePlus   UniProt 23186163
T899 Phosphorylation Q9P2K8 (EIF2AK4) neXtProt   PhosphoSitePlus   RLIMS-P 25589675, 26709701, 9528799, ...29383104, 21849502, 33289483
T904 Phosphorylation Q9P2K8 (EIF2AK4) neXtProt 9528799, 21849502
S928 Phosphorylation PhosphoSitePlus
T991 Phosphorylation PhosphoSitePlus
T1085 Phosphorylation PhosphoSitePlus
K1135 Methylation PhosphoSitePlus
K1135 Ubiquitination PhosphoSitePlus
K1259 Acetylation PhosphoSitePlus   UniProt 19608861
K1489 Ubiquitination PhosphoSitePlus
K1627 Ubiquitination PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S205 Phosphorylation HPRD 18691976
S230 Phosphorylation HPRD 18691976, 18669648, 20068231
T667 Phosphorylation HPRD 19651622, 18691976, 20068231
S1040 Phosphorylation HPRD 20068231


Q9P2K8 (EIF2AK4) as PTM Enzyme



Substrate Site Score Source PMID
P05198 (EIF2S1) S52 neXtProt   Signor 15355306, 15684420, 10504407, ...32513922
P56192 (MARS1) S229 PhosphoSitePlus 22106287
P56192 (MARS1) S472 PhosphoSitePlus 22106287
P56192 (MARS1) S662 PhosphoSitePlus   Signor 22106287
Q9P2K8 (EIF2AK4) T899 neXtProt 9528799, 21849502
Q9P2K8 (EIF2AK4) T904 neXtProt 9528799, 21849502


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S261 F261 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S551 N551 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S551 C551 Biomuta DOID:1324 / lung cancer [ cosmic ]
T904 S904 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S1040 P1040 Biomuta DOID:1319 / brain cancer [ cosmic ]
T1085 A1085 Biomuta DOID:4159 / skin cancer [ cosmic ]
K1135 E1135 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]
K1627 E1627 Biomuta DOID:9256 / colorectal cancer [ cosmic ]