iPTMnet Report for Q9P0V3 (SH3BP4)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9P0V3 / SH3B4_HUMAN
Protein Name SH3 domain-binding protein 4
Gene Name Name: SH3BP4
Synonyms:BOG25,EHB10,TTP;
Organism Homo sapiens (Human)

PRO ID PR:Q9P0V3
DAG View
PRO Name SH3 domain-binding protein 4 (human)
Definition An SH3 domain-binding protein 4 that is encoded in the genome of human.
Short Label hSH3BP4
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9P0V3 (SH3BP4) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S11 Phosphorylation PhosphoSitePlus
S19 Phosphorylation PhosphoSitePlus
S42 Phosphorylation PhosphoSitePlus
S44 Phosphorylation PhosphoSitePlus
K64 Ubiquitination PhosphoSitePlus
T118 Phosphorylation PhosphoSitePlus
S122 Phosphorylation PhosphoSitePlus
S131 Phosphorylation PhosphoSitePlus   UniProt 18691976
T146 Phosphorylation PhosphoSitePlus
K149 Ubiquitination PhosphoSitePlus
S241 Phosphorylation PhosphoSitePlus
S244 Phosphorylation PhosphoSitePlus
S246 Phosphorylation P31749 (AKT1) neXtProt   phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 19122209
S248 Phosphorylation PhosphoSitePlus
S251 Phosphorylation PhosphoSitePlus
S264 Phosphorylation PhosphoSitePlus
K270 Methylation PhosphoSitePlus
K270 Ubiquitination PhosphoSitePlus
S271 Phosphorylation PhosphoSitePlus
S279 Phosphorylation PhosphoSitePlus   UniProt 23186163
S296 Phosphorylation PhosphoSitePlus   UniProt 24275569
S306 Phosphorylation PhosphoSitePlus
C321 Methylation IEDB 31844290
K381 Ubiquitination PhosphoSitePlus
K473 Ubiquitination PhosphoSitePlus
Y479 Phosphorylation PhosphoSitePlus
K557 Ubiquitination PhosphoSitePlus
S615 Phosphorylation PhosphoSitePlus
K633 Ubiquitination PhosphoSitePlus
S637 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 23186163, 16964243, 20068231
K644 Ubiquitination PhosphoSitePlus
T647 Phosphorylation PhosphoSitePlus
S655 Phosphorylation PhosphoSitePlus
K657 Ubiquitination PhosphoSitePlus
K678 Ubiquitination PhosphoSitePlus
K679 Ubiquitination PhosphoSitePlus
S877 Phosphorylation phospho.ELM   PhosphoSitePlus 17081983
Site PTM Type PTM Enzyme Score Source PMID
S44 Phosphorylation HPRD 18578522
S131 Phosphorylation HPRD 18691976
S246 Phosphorylation HPRD 19651622, 18669648, 20058876, ...19664995
S637 Phosphorylation HPRD 16964243, 20068231
Y875 Phosphorylation HPRD 17081983


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
T118 R118 Biomuta DOID:4159 / skin cancer [ cosmic ]
T118 S118 Biomuta DOID:1319 / brain cancer [ cosmic, icgc ]
T118 A118 Biomuta DOID:3571 / liver cancer [ cosmic, icgc ]
T146 A146 Biomuta DOID:363 / uterine cancer [ icgc ]
K149 Q149 Biomuta DOID:4362 / cervical cancer [ cosmic, icgc ]
K270 * Biomuta DOID:263 / kidney cancer [ cosmic ]
S637 F637 Biomuta DOID:4159 / skin cancer [ cosmic ]
S655 C655 Biomuta DOID:4606 / bile duct cancer [ cosmic ]
S655 N655 Biomuta DOID:1324 / lung cancer [ cosmic ]