Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9NZJ5 / E2AK3_HUMAN
Protein Name Eukaryotic translation initiation factor 2-alpha kinase 3 precursor
Gene Name Name: EIF2AK3
Synonyms:PEK,PERK;
Organism Homo sapiens (Human)

PRO ID PR:Q9NZJ5
DAG View
PRO Name eukaryotic translation initiation factor 2-alpha kinase 3 (human)
Definition A eukaryotic translation initiation factor 2-alpha kinase 3 that is encoded in the genome of human.
Short Label hEIF2AK3
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9NZJ5 (EIF2AK3) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
T54 O-Glycosylation GlyGen 25813380
S55 O-Glycosylation GlyGen 25813380
T57 O-Glycosylation GlyGen 25813380
T177 Phosphorylation PhosphoSitePlus
N254 N-Glycosylation GlyGen 24190977
N258 N-Glycosylation GlyGen 24190977
Y268 Phosphorylation PhosphoSitePlus
T441 Phosphorylation PhosphoSitePlus
S447 Phosphorylation PhosphoSitePlus
K452 Ubiquitination PhosphoSitePlus
S455 Phosphorylation PhosphoSitePlus
Y464 Phosphorylation PhosphoSitePlus
Y474 Phosphorylation PhosphoSitePlus
Y480 Phosphorylation PhosphoSitePlus
Y481 Phosphorylation PhosphoSitePlus
Y484 Phosphorylation PhosphoSitePlus
Y485 Phosphorylation PhosphoSitePlus
S555 Phosphorylation PhosphoSitePlus
T557 Phosphorylation PhosphoSitePlus
T561 Phosphorylation PhosphoSitePlus
S567 Phosphorylation PhosphoSitePlus
K581 Ubiquitination PhosphoSitePlus
Y585 Phosphorylation PhosphoSitePlus
Y619 Phosphorylation PhosphoSitePlus   RLIMS-P   Signor   UniProt 17998206, 22169477
Y619 Phosphorylation Q9NZJ5 (EIF2AK3) Signor 17998206
K622 Ubiquitination PhosphoSitePlus
K669 Ubiquitination PhosphoSitePlus
S688 Phosphorylation PhosphoSitePlus
S694 Phosphorylation PhosphoSitePlus
T705 Phosphorylation PhosphoSitePlus
S715 Phosphorylation HPRD   PhosphoSitePlus   UniProt 18691976, 20068231
S719 Phosphorylation PhosphoSitePlus
T802 Phosphorylation neXtProt   PhosphoSitePlus 21954288
T802 Phosphorylation P31749 (AKT1) neXtProt 21954288
T802 Phosphorylation P31751 (AKT2) neXtProt 21954288
S803 Phosphorylation PhosphoSitePlus
S804 Phosphorylation PhosphoSitePlus
S811 Phosphorylation PhosphoSitePlus
S844 Phosphorylation PhosphoSitePlus
S845 Phosphorylation PhosphoSitePlus
S854 Phosphorylation PhosphoSitePlus
S856 Phosphorylation PhosphoSitePlus
T861 Phosphorylation HPRD 20068231
T862 Phosphorylation HPRD 20068231
S879 Phosphorylation PhosphoSitePlus
T982 Phosphorylation PhosphoSitePlus
S1094 Phosphorylation PhosphoSitePlus   UniProt 21406692
S1096 Phosphorylation PhosphoSitePlus
S1109 Phosphorylation PhosphoSitePlus
S1111 Phosphorylation PhosphoSitePlus


Q9NZJ5 (EIF2AK3) as PTM Enzyme



Substrate Site Score Source PMID
P05198 (EIF2S1) S49 PhosphoSitePlus 16289913
P05198 (EIF2S1) S52 HPRD   neXtProt   phospho.ELM   PhosphoSitePlus   Signor 17998206, 11907036, 8099443, ...15314157, 9819435, 10542257, 20385091, 9930704, 30070006, 25660019, 1677563
Q9NZJ5 (EIF2AK3) Y619 Signor 17998206