iPTMnet Report for Q9NZI8 (IGF2BP1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9NZI8 / IF2B1_HUMAN
Protein Name Insulin-like growth factor 2 mRNA-binding protein 1
Gene Name Name: IGF2BP1
Synonyms:CRDBP,VICKZ1,ZBP1;
Organism Homo sapiens (Human)

PRO ID PR:Q9NZI8
DAG View
PRO Name insulin-like growth factor 2 mRNA-binding protein 1 (human)
Definition An insulin-like growth factor 2 mRNA-binding protein 1 that is encoded in the genome of human.
Short Label hIGF2BP1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9NZI8 (IGF2BP1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K3 Ubiquitination PhosphoSitePlus
S12 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163
K20 Ubiquitination PhosphoSitePlus
K26 Ubiquitination PhosphoSitePlus
Y39 Phosphorylation PhosphoSitePlus
K52 Ubiquitination PhosphoSitePlus
K66 Ubiquitination PhosphoSitePlus
S73 Phosphorylation PhosphoSitePlus   UniProt 23186163
K76 Ubiquitination PhosphoSitePlus
K138 Ubiquitination PhosphoSitePlus
K150 Ubiquitination PhosphoSitePlus
R168 Methylation PhosphoSitePlus
S173 Phosphorylation PhosphoSitePlus
R174 Methylation PhosphoSitePlus
S181 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 17287340, 16964243, 15302935, ...18669648, 23186163, 15659558, 20068231, 17081983
K190 Ubiquitination PhosphoSitePlus
K213 Ubiquitination PhosphoSitePlus
T217 Phosphorylation PhosphoSitePlus
K223 Ubiquitination PhosphoSitePlus
K228 Ubiquitination PhosphoSitePlus
K234 Ubiquitination PhosphoSitePlus
K242 Ubiquitination PhosphoSitePlus
T249 Phosphorylation PhosphoSitePlus
K272 Ubiquitination PhosphoSitePlus
T273 Phosphorylation PhosphoSitePlus
K280 Ubiquitination PhosphoSitePlus
K294 Ubiquitination PhosphoSitePlus
K300 Acetylation PhosphoSitePlus
K300 Ubiquitination PhosphoSitePlus
K301 Acetylation PhosphoSitePlus
K301 Ubiquitination PhosphoSitePlus
K309 Acetylation PhosphoSitePlus
T326 Phosphorylation PhosphoSitePlus
T328 Phosphorylation PhosphoSitePlus
K330 Ubiquitination PhosphoSitePlus
Y396 Phosphorylation PhosphoSitePlus
K429 Ubiquitination PhosphoSitePlus
S432 Phosphorylation PhosphoSitePlus
S438 Phosphorylation PhosphoSitePlus
K440 Ubiquitination PhosphoSitePlus
T446 Phosphorylation PhosphoSitePlus
K450 Ubiquitination PhosphoSitePlus
K465 Methylation PhosphoSitePlus
K465 Ubiquitination PhosphoSitePlus
K475 Sumoylation PhosphoSitePlus
K475 Ubiquitination PhosphoSitePlus
K483 Ubiquitination PhosphoSitePlus
T490 Phosphorylation PhosphoSitePlus
R493 Methylation PhosphoSitePlus
S497 Phosphorylation PhosphoSitePlus
K508 Ubiquitination PhosphoSitePlus
T517 Phosphorylation PhosphoSitePlus
T528 Phosphorylation PhosphoSitePlus   UniProt 23186163
K538 Ubiquitination PhosphoSitePlus
S546 Phosphorylation PhosphoSitePlus
K561 Ubiquitination PhosphoSitePlus
K566 Ubiquitination PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
M1 Acetylation PRO
S12 Phosphorylation HPRD 18669648, 20068231
S181 Phosphorylation HPRD 19413330, 18691976, 17287340, ...18212344, 19007248, 15144186, 19664995, 19651622, 18669648, 18707149, 20068231, 17924679
T446 Phosphorylation HPRD 19413330


Proteoforms

PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000036268 (hIGF2BP1/Ac:1) acM1 PRO


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K26 Q26 Biomuta DOID:1324 / lung cancer [ cosmic ]
K52 R52 Biomuta DOID:2394 / ovarian cancer [ cosmic, icgc ]
S73 L73 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
R168 * Biomuta DOID:9256 / colorectal cancer [ cosmic ]
R168 Q168 Biomuta [ cosmic ] DOID:1612 / breast cancer [ cosmic ] DOID:1324 / lung cancer [ cosmic, icgc ]
R174 W174 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ] DOID:1319 / brain cancer [ cosmic, icgc ] DOID:10534 / stomach cancer [ cosmic, icgc ]
R174 Q174 Biomuta [ cosmic ] DOID:9256 / colorectal cancer [ cosmic, icgc ] DOID:1115 / sarcoma [ icgc ] DOID:11054 / urinary bladder cancer [ cosmic ]
K213 N213 Biomuta DOID:363 / uterine cancer [ icgc ]
T217 I217 Biomuta DOID:10534 / stomach cancer [ cosmic ]
K228 N228 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K228 E228 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ] DOID:10534 / stomach cancer [ cosmic ]
T249 S249 Biomuta [ cosmic ] DOID:1115 / sarcoma [ icgc ]
K272 N272 Biomuta DOID:363 / uterine cancer [ icgc ]
T273 M273 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
K300 E300 Biomuta DOID:363 / uterine cancer [ icgc ]
T328 N328 Biomuta DOID:9253 / gastrointestinal stromal tumor [ cosmic ]
K429 E429 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
K440 N440 Biomuta DOID:4362 / cervical cancer [ cosmic, icgc ]
K465 N465 Biomuta DOID:4159 / skin cancer [ cosmic ]
K483 N483 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
R493 C493 Biomuta DOID:1324 / lung cancer [ cosmic ]
S497 A497 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
T517 M517 Biomuta DOID:363 / uterine cancer [ cosmic ] DOID:9256 / colorectal cancer [ icgc ]
K538 N538 Biomuta DOID:363 / uterine cancer [ icgc ]
K538 I538 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]