iPTMnet Report for Q9NZ63 (C9orf78)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9NZ63 / TLS1_HUMAN
Protein Name Splicing factor C9orf78
Gene Name Name: C9orf78
Synonyms:HCA59;
Organism Homo sapiens (Human)

PRO ID PR:Q9NZ63
DAG View
PRO Name splicing factor C9orf78 (human)
Definition A splicing factor C9orf78 that is encoded in the genome of human.
Short Label hC9orf78
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9NZ63 (C9orf78) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S15 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 18491316, 23186163, 17081983, ...18452278, 19651622, 18669648, 16083285, 19690332, 20068231
S17 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 16083285, 23186163, 17081983, ...15302935, 18452278, 19651622, 18669648, 18491316, 19690332, 20068231
S24 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 19651622, 17081983
K30 Ubiquitination PhosphoSitePlus
S48 Phosphorylation PhosphoSitePlus
K72 Ubiquitination PhosphoSitePlus
K80 Acetylation PhosphoSitePlus
S101 Phosphorylation PhosphoSitePlus
Y118 Phosphorylation PhosphoSitePlus
T121 Phosphorylation HPRD   PhosphoSitePlus 20068231
K124 Ubiquitination PhosphoSitePlus
K127 Acetylation PhosphoSitePlus
K136 Acetylation PhosphoSitePlus
K136 Ubiquitination PhosphoSitePlus
Y147 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 15592455, 19901323, 17287340
S156 Phosphorylation PhosphoSitePlus
S157 Phosphorylation PhosphoSitePlus
K160 Ubiquitination PhosphoSitePlus
T161 Phosphorylation PhosphoSitePlus
K185 Ubiquitination PhosphoSitePlus
K194 Ubiquitination PhosphoSitePlus
K204 Ubiquitination PhosphoSitePlus
Y221 Phosphorylation PhosphoSitePlus
R226 Methylation PhosphoSitePlus
Y228 Phosphorylation PhosphoSitePlus
T253 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 19651622, 17081983, 18220336, ...18452278, 17322306, 18669648, 24275569, 20068231
S261 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 17322306, 21406692, 23186163, ...17081983, 18220336, 18767875, 19664995, 18452278, 19651622, 18669648, 18707149, 20166139, 17287340, 20068231, 17924679
Y277 Phosphorylation PhosphoSitePlus
Y279 Phosphorylation PhosphoSitePlus
K281 Ubiquitination PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S15 W15 Biomuta DOID:184 / bone cancer [ cosmic ]
S15 * Biomuta DOID:3571 / liver cancer [ cosmic ]
S15 L15 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
S101 L101 Biomuta [ cosmic ] DOID:363 / uterine cancer [ icgc ]
S156 F156 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
K204 E204 Biomuta DOID:1612 / breast cancer [ cosmic ]
R226 T226 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
Y279 C279 Biomuta DOID:10534 / stomach cancer [ cosmic ]