iPTMnet Report for Q9NWS9 (ZNF446)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9NWS9 / ZN446_HUMAN
Protein Name Zinc finger protein 446
Gene Name Name: ZNF446
Synonyms:ZKSCAN20;
Organism Homo sapiens (Human)

PRO ID PR:Q9NWS9
DAG View
PRO Name zinc finger protein 446 (human)
Definition A zinc finger protein 446 that is encoded in the genome of human.
Short Label hZNF446
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9NWS9 (ZNF446) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S3 Phosphorylation PhosphoSitePlus
T131 Phosphorylation PhosphoSitePlus
S137 Phosphorylation PhosphoSitePlus   UniProt 21406692, 23186163, 19690332, ...24275569
S141 Phosphorylation PhosphoSitePlus
S146 Phosphorylation PhosphoSitePlus
S159 Phosphorylation PhosphoSitePlus
S188 Phosphorylation PhosphoSitePlus
S218 Phosphorylation PhosphoSitePlus   UniProt 23186163
K220 Ubiquitination PhosphoSitePlus
T303 Phosphorylation PhosphoSitePlus
T308 Phosphorylation PhosphoSitePlus   UniProt 24275569
T320 Phosphorylation PhosphoSitePlus
T327 Phosphorylation PhosphoSitePlus
K330 Sumoylation PhosphoSitePlus
S362 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S3 F3 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
T131 R131 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
T131 A131 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
T131 I131 Biomuta DOID:363 / uterine cancer [ icgc ]
S159 Y159 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
S188 F188 Biomuta DOID:1612 / breast cancer [ icgc ]
T320 M320 Biomuta DOID:10534 / stomach cancer [ cosmic ]
T327 P327 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]