iPTMnet Report for Q9NUL3 (STAU2)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9NUL3 / STAU2_HUMAN
Protein Name Double-stranded RNA-binding protein Staufen homolog 2
Gene Name Name: STAU2
Organism Homo sapiens (Human)

PRO ID PR:Q9NUL3
DAG View
PRO Name double-stranded RNA-binding protein Staufen homolog 2 (human)
Definition A double-stranded RNA-binding protein Staufen homolog 2 that is encoded in the genome of human.
Short Label hSTAU2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9NUL3 (STAU2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K60 Ubiquitination PhosphoSitePlus
K68 Ubiquitination PhosphoSitePlus
K81 Ubiquitination PhosphoSitePlus
T95 Phosphorylation PhosphoSitePlus
K106 Ubiquitination PhosphoSitePlus
R107 Methylation PhosphoSitePlus
Y113 Phosphorylation PhosphoSitePlus
R114 Methylation PhosphoSitePlus
K119 Ubiquitination PhosphoSitePlus
R131 Methylation PhosphoSitePlus
R137 Methylation PhosphoSitePlus
Y138 Phosphorylation PhosphoSitePlus
K162 Ubiquitination PhosphoSitePlus
K174 Ubiquitination PhosphoSitePlus
S188 Phosphorylation PhosphoSitePlus   UniProt 18691976, 21406692
S194 Phosphorylation PhosphoSitePlus
K257 Ubiquitination PhosphoSitePlus
T267 Phosphorylation PhosphoSitePlus
K297 Ubiquitination PhosphoSitePlus
Y302 Phosphorylation PhosphoSitePlus
K319 Ubiquitination PhosphoSitePlus
K322 Ubiquitination PhosphoSitePlus
Y326 Phosphorylation PhosphoSitePlus
K358 Ubiquitination PhosphoSitePlus
K387 Ubiquitination PhosphoSitePlus
K392 Ubiquitination PhosphoSitePlus
S395 Phosphorylation PhosphoSitePlus   UniProt 20068231
K398 Ubiquitination PhosphoSitePlus
T405 Phosphorylation PhosphoSitePlus   UniProt 20068231
T408 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
K410 Ubiquitination PhosphoSitePlus
S416 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18691976, 23186163, 18220336, ...16565220, 18669648, 20068231
Y420 Phosphorylation PhosphoSitePlus
S426 Phosphorylation PhosphoSitePlus   UniProt 20068231
K429 Ubiquitination PhosphoSitePlus
S432 Phosphorylation PhosphoSitePlus
T434 O-Glycosylation GlyGen 23301498, 34019948, 35254053, ...35132862, 28657654
T435 O-Glycosylation GlyGen 23301498, 34019948, 35254053, ...35132862, 28657654
Y438 Phosphorylation PhosphoSitePlus
S440 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 23186163, 16964243, 18669648, ...19690332, 20068231
S449 Phosphorylation PhosphoSitePlus
S455 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 20068231
S474 Phosphorylation PhosphoSitePlus
S475 Phosphorylation PhosphoSitePlus
S485 Phosphorylation PhosphoSitePlus
S486 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
T488 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S492 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 19690332
K498 Ubiquitination PhosphoSitePlus
Y502 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S156 Phosphorylation HPRD 19651622, 18691976, 20068231
S363 Phosphorylation HPRD 20068231
T373 Phosphorylation HPRD 20068231
T376 Phosphorylation HPRD 18669648, 20068231
S384 Phosphorylation HPRD 19651622, 18691976, 18669648, ...20068231, 16565220
S394 Phosphorylation HPRD 20068231
S408 Phosphorylation HPRD 18691976, 16964243, 19664994, ...18669648, 18707149, 20068231, 18212344
S423 Phosphorylation HPRD 18691976, 18669648, 20068231
S426 Phosphorylation HPRD 20068231
S454 Phosphorylation HPRD 19413330, 18669648, 19664995
T456 Phosphorylation HPRD 19413330, 18669648
S460 Phosphorylation HPRD 19413330, 18669648


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
R107 S107 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
R131 W131 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
Y138 * Biomuta DOID:1319 / brain cancer [ cosmic ]
S156 Y156 Biomuta DOID:1319 / brain cancer [ cosmic, icgc ]
S188 Y188 Biomuta DOID:1319 / brain cancer [ cosmic, icgc ]
S194 L194 Biomuta DOID:4159 / skin cancer [ cosmic, icgc, tcga ] DOID:1324 / lung cancer [ cosmic, icgc ]
K297 N297 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S363 R363 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
S395 R395 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
S408 * Biomuta DOID:10534 / stomach cancer [ cosmic ]
S426 L426 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ] DOID:4159 / skin cancer [ cosmic, icgc ] DOID:9256 / colorectal cancer [ cosmic ]
S440 * Biomuta DOID:10534 / stomach cancer [ cosmic ]
S475 P475 Biomuta DOID:10534 / stomach cancer [ cosmic ]