iPTMnet Report for Q9NSE4 (IARS2)
Protein Information
UniProt AC / UniProt ID | Q9NSE4 / SYIM_HUMAN |
Protein Name | Isoleucine--tRNA ligase, mitochondrial precursor |
Gene Name | Name: IARS2 |
Organism | Homo sapiens (Human) |
PRO ID | PR:Q9NSE4 |
PRO Name | isoleucine--tRNA ligase, mitochondrial (human) |
Definition | An isoleucine--tRNA ligase, mitochondrial that is encoded in the genome of human. |
Short Label | hIARS2 |
Category | organism-gene |
Q9NSE4 (IARS2) as Substrate
Site | PTM Type | PTM Enzyme | Score | Source | PMID | |
---|---|---|---|---|---|---|
S44 | Phosphorylation | score1 | PhosphoSitePlus | |||
S46 | Phosphorylation | score1 | PhosphoSitePlus | |||
S57 | Phosphorylation | score1 | PhosphoSitePlus | |||
Y60 | Phosphorylation | score1 | PhosphoSitePlus | |||
K74 | Acetylation | score1 | PhosphoSitePlus | |||
K133 | Ubiquitination | score1 | PhosphoSitePlus | |||
S186 | Phosphorylation | score2 | HPRD phospho.ELM PhosphoSitePlus | 17081983, 20068231 | ||
K189 | Acetylation | score2 | PhosphoSitePlus UniProt | 19608861 | ||
K189 | Ubiquitination | score1 | PhosphoSitePlus | |||
K222 | Acetylation | score1 | PhosphoSitePlus | |||
R225 | Methylation | score1 | PhosphoSitePlus | |||
Y231 | Phosphorylation | score1 | PhosphoSitePlus | |||
K233 | Acetylation | score2 | PhosphoSitePlus UniProt | 19608861 | ||
Y237 | Phosphorylation | score1 | PhosphoSitePlus | |||
K241 | Acetylation | score2 | PhosphoSitePlus UniProt | 19608861 | ||
K241 | Methylation | score1 | PhosphoSitePlus | |||
K241 | Ubiquitination | score1 | PhosphoSitePlus | |||
T251 | Phosphorylation | score1 | PhosphoSitePlus | |||
Y260 | Phosphorylation | score1 | PhosphoSitePlus | |||
K445 | Ubiquitination | score1 | PhosphoSitePlus | |||
K455 | Sumoylation | score1 | PhosphoSitePlus | |||
K458 | Ubiquitination | score1 | PhosphoSitePlus | |||
K479 | Acetylation | score1 | PhosphoSitePlus | |||
K493 | Ubiquitination | score1 | PhosphoSitePlus | |||
K500 | Acetylation | score1 | PhosphoSitePlus | |||
K540 | Ubiquitination | score1 | PhosphoSitePlus | |||
Y543 | Phosphorylation | score1 | PhosphoSitePlus | |||
S547 | Phosphorylation | score1 | PhosphoSitePlus | |||
Y621 | Phosphorylation | score1 | PhosphoSitePlus | |||
T657 | Phosphorylation | score1 | PhosphoSitePlus | |||
K687 | Ubiquitination | score1 | PhosphoSitePlus | |||
K725 | Acetylation | score1 | PhosphoSitePlus | |||
K775 | Acetylation | score2 | PhosphoSitePlus UniProt | 19608861 | ||
K781 | Acetylation | score2 | PhosphoSitePlus UniProt | 19608861 | ||
Y798 | Phosphorylation | score1 | PhosphoSitePlus | |||
K803 | Acetylation | score1 | PhosphoSitePlus | |||
K872 | Ubiquitination | score1 | PhosphoSitePlus | |||
S881 | Phosphorylation | score2 | HPRD PhosphoSitePlus | 20068231 | ||
S888 | Phosphorylation | score1 | PhosphoSitePlus | |||
K896 | Ubiquitination | score1 | PhosphoSitePlus | |||
T950 | Phosphorylation | score2 | HPRD PhosphoSitePlus | 20068231 | ||
T982 | Phosphorylation | score0 | HPRD | 20068231 | ||
C1005 | S-Nitrosylation | score0 | dbSNO | 26338901 |
PTM sites affected in variants
Site | Variant | Source | PMID | Disease [Sample source] |
---|---|---|---|---|
S44 | * | Biomuta | DOID:1324 / lung cancer [ cosmic ] | |
K133 | E133 | Biomuta | DOID:10534 / stomach cancer [ cosmic ] | |
R225 | T225 | Biomuta | DOID:4362 / cervical cancer [ cosmic ] | |
K493 | N493 | Biomuta | DOID:263 / kidney cancer [ cosmic ] | |
K540 | N540 | Biomuta | DOID:9256 / colorectal cancer [ cosmic ] | |
K687 | N687 | Biomuta | DOID:3571 / liver cancer [ cosmic ] | |
K687 | E687 | Biomuta | DOID:1324 / lung cancer [ cosmic ] | |
K725 | N725 | Biomuta | DOID:2394 / ovarian cancer [ cosmic ] | |
K781 | N781 | Biomuta | DOID:9256 / colorectal cancer [ cosmic ] |