iPTMnet Report for Q9NRX4 (PHPT1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9NRX4 / PHP14_HUMAN
Protein Name 14 kDa phosphohistidine phosphatase
Gene Name Name: PHPT1
Synonyms:PHP14;ORFNames:CGI-202,HSPC141;
Organism Homo sapiens (Human)

PRO ID PR:Q9NRX4
DAG View
PRO Name 14 kDa phosphohistidine phosphatase (human)
Definition A 14 kDa phosphohistidine phosphatase that is encoded in the genome of human.
Short Label hPHPT1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9NRX4 (PHPT1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
A2 Acetylation UniProt 19413330, 22814378, 22223895
S16 Phosphorylation PhosphoSitePlus
Y22 Phosphorylation PhosphoSitePlus
S29 Phosphorylation PhosphoSitePlus
S33 Phosphorylation PhosphoSitePlus
S40 Phosphorylation PhosphoSitePlus
K41 Ubiquitination PhosphoSitePlus
Y57 Phosphorylation PhosphoSitePlus
K59 Ubiquitination PhosphoSitePlus
K66 Ubiquitination PhosphoSitePlus
K86 Acetylation PhosphoSitePlus
Y91 Phosphorylation PhosphoSitePlus
Y93 Phosphorylation PhosphoSitePlus
S94 Phosphorylation PhosphoSitePlus
Y97 Phosphorylation PhosphoSitePlus
K112 Ubiquitination PhosphoSitePlus
Y113 Phosphorylation PhosphoSitePlus
Y116 Phosphorylation PhosphoSitePlus
Y125 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S29 W29 Biomuta DOID:1324 / lung cancer [ cosmic ]
S29 L29 Biomuta DOID:1612 / breast cancer [ icgc ]
S33 C33 Biomuta DOID:4362 / cervical cancer [ cosmic, icgc ]
Y93 C93 Biomuta DOID:263 / kidney cancer [ cosmic, icgc ]
Y116 F116 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]