iPTMnet Report for Q9NRG4 (SMYD2)
Protein Information
UniProt AC / UniProt ID | Q9NRG4 / SMYD2_HUMAN |
Protein Name | N-lysine methyltransferase SMYD2 |
Gene Name | Name: SMYD2 Synonyms:KMT3C; |
Organism | Homo sapiens (Human) |
PRO ID | PR:Q9NRG4 |
PRO Name | N-lysine methyltransferase SMYD2 (human) |
Definition | An N-lysine methyltransferase SMYD2 that is encoded in the genome of human. |
Short Label | hSMYD2 |
Category | organism-gene |
Q9NRG4 (SMYD2) as Substrate
Site | PTM Type | PTM Enzyme | Score | Source | PMID | |
---|---|---|---|---|---|---|
S35 | Phosphorylation | score1 | PhosphoSitePlus | |||
T44 | Phosphorylation | score1 | PhosphoSitePlus | |||
K80 | Ubiquitination | score1 | PhosphoSitePlus | |||
K127 | Ubiquitination | score1 | PhosphoSitePlus | |||
K132 | Ubiquitination | score1 | PhosphoSitePlus | |||
K145 | Ubiquitination | score1 | PhosphoSitePlus | |||
K146 | Ubiquitination | score1 | PhosphoSitePlus | |||
S283 | Phosphorylation | score2 | PhosphoSitePlus UniProt | 23186163 | ||
K312 | Ubiquitination | score1 | PhosphoSitePlus | |||
K398 | Methylation | score1 | PhosphoSitePlus | |||
K418 | Ubiquitination | score1 | PhosphoSitePlus | |||
K427 | Ubiquitination | score1 | PhosphoSitePlus |
PTM sites affected in variants
Site | Variant | Source | PMID | Disease [Sample source] |
---|---|---|---|---|
T44 | K44 | Biomuta | DOID:9256 / colorectal cancer [ cosmic ] | |
T44 | A44 | Biomuta | DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ] | |
K127 | T127 | Biomuta | DOID:363 / uterine cancer [ cosmic, icgc ] DOID:9256 / colorectal cancer [ cosmic ] | |
K145 | N145 | Biomuta | DOID:1324 / lung cancer [ cosmic ] | |
K427 | E427 | Biomuta | DOID:9256 / colorectal cancer [ cosmic ] |