iPTMnet Report for Q9NRF9 (POLE3)
Protein Information
UniProt AC / UniProt ID | Q9NRF9 / DPOE3_HUMAN |
Protein Name | DNA polymerase epsilon subunit 3 |
Gene Name | Name: POLE3 Synonyms:CHRAC17; |
Organism | Homo sapiens (Human) |
PRO ID | PR:Q9NRF9 |
PRO Name | DNA polymerase epsilon subunit 3 (human) |
Definition | A DNA polymerase epsilon subunit 3 that is encoded in the genome of human. |
Short Label | hPOLE3 |
Category | organism-gene |
Q9NRF9 (POLE3) as Substrate
Site | PTM Type | PTM Enzyme | Score | Source | PMID | |
---|---|---|---|---|---|---|
A2 | Acetylation | score1 | UniProt | 19413330 | ||
K20 | Ubiquitination | score1 | PhosphoSitePlus | |||
K31 | Acetylation | score1 | PhosphoSitePlus | |||
K31 | Ubiquitination | score1 | PhosphoSitePlus | |||
S35 | Phosphorylation | score1 | PhosphoSitePlus | |||
S38 | Phosphorylation | score1 | PhosphoSitePlus | |||
K62 | Ubiquitination | score1 | PhosphoSitePlus | |||
T63 | Phosphorylation | score2 | HPRD phospho.ELM PhosphoSitePlus | 18669648, 20068231 | ||
S67 | Phosphorylation | score1 | PhosphoSitePlus | |||
S71 | Phosphorylation | score1 | PhosphoSitePlus | |||
T83 | Phosphorylation | score2 | HPRD phospho.ELM PhosphoSitePlus UniProt | 18669648 | ||
K86 | Ubiquitination | score1 | PhosphoSitePlus | |||
Y92 | Phosphorylation | score1 | PhosphoSitePlus | |||
S116 | Phosphorylation | score2 | HPRD phospho.ELM | 18669648 | ||
S122 | Phosphorylation | score2 | HPRD phospho.ELM PhosphoSitePlus UniProt | 18691976, 21406692, 17081983, ... | ||
R123 | Methylation | score1 | PhosphoSitePlus | |||
R133 | Methylation | score1 | PhosphoSitePlus |
PTM sites affected in variants
Site | Variant | Source | PMID | Disease [Sample source] |
---|---|---|---|---|
A2 | T2 | Biomuta | DOID:363 / uterine cancer [ icgc ] | |
T63 | M63 | Biomuta | DOID:9256 / colorectal cancer [ cosmic, icgc ] | |
S67 | G67 | Biomuta | DOID:10534 / stomach cancer [ cosmic ] | |
S116 | L116 | Biomuta | DOID:363 / uterine cancer [ cosmic, icgc ] DOID:11054 / urinary bladder cancer [ cosmic, icgc ] | |
S116 | * | Biomuta | DOID:363 / uterine cancer [ cosmic ] |