iPTMnet Report for Q9NRF2 (SH2B1)
Protein Information
UniProt AC / UniProt ID | Q9NRF2 / SH2B1_HUMAN |
Protein Name | SH2B adapter protein 1 |
Gene Name | Name: SH2B1 Synonyms:KIAA1299,SH2B; |
Organism | Homo sapiens (Human) |
PRO ID | PR:Q9NRF2 |
PRO Name | SH2B adapter protein 1 (human) |
Definition | An SH2B adapter protein 1 that is encoded in the genome of human. |
Short Label | hSH2B1 |
Category | organism-gene |
Q9NRF2 (SH2B1) as Substrate
Site | PTM Type | PTM Enzyme | Score | Source | PMID | |
---|---|---|---|---|---|---|
Y48 | Phosphorylation | score1 | PhosphoSitePlus | |||
S51 | Phosphorylation | score1 | PhosphoSitePlus | |||
Y55 | Phosphorylation | score1 | PhosphoSitePlus | |||
S65 | Phosphorylation | score1 | PhosphoSitePlus | |||
S84 | Phosphorylation | score1 | PhosphoSitePlus | |||
S88 | Phosphorylation | score1 | PhosphoSitePlus | |||
S96 | Phosphorylation | P28482 (MAPK1) , P27361 (MAPK3) | score4 | neXtProt PhosphoSitePlus UniProt | 18669648, 10473609, 18220336 | |
S102 | Phosphorylation | score1 | PhosphoSitePlus | |||
S107 | Phosphorylation | score1 | PhosphoSitePlus | |||
S110 | Phosphorylation | score1 | PhosphoSitePlus | |||
S123 | Phosphorylation | score1 | PhosphoSitePlus | |||
S125 | Phosphorylation | score1 | PhosphoSitePlus | |||
S126 | Phosphorylation | score1 | PhosphoSitePlus | |||
S154 | Phosphorylation | score1 | PhosphoSitePlus | |||
S157 | Phosphorylation | score1 | PhosphoSitePlus | |||
S161 | Phosphorylation | P17252 (PRKCA) | score2 | PhosphoSitePlus | 21878491 | |
S165 | Phosphorylation | P17252 (PRKCA) | score2 | PhosphoSitePlus | 21878491 | |
R211 | Methylation | score1 | PhosphoSitePlus | |||
S219 | Phosphorylation | score1 | PhosphoSitePlus | |||
R235 | Methylation | score1 | PhosphoSitePlus | |||
R270 | Methylation | score2 | PhosphoSitePlus UniProt | 24129315 | ||
K289 | Ubiquitination | score1 | PhosphoSitePlus | |||
S320 | Phosphorylation | score1 | PhosphoSitePlus | |||
S352 | Phosphorylation | score1 | PhosphoSitePlus | |||
S376 | Phosphorylation | score1 | PhosphoSitePlus | |||
S384 | Phosphorylation | score1 | PhosphoSitePlus | |||
S417 | Phosphorylation | score1 | PhosphoSitePlus | |||
Y439 | Phosphorylation | score1 | PhosphoSitePlus | |||
S580 | Phosphorylation | score1 | PhosphoSitePlus | |||
Y624 | Phosphorylation | score1 | PhosphoSitePlus | |||
Y753 | Phosphorylation | score1 | PhosphoSitePlus |
PTM sites affected in variants
Site | Variant | Source | PMID | Disease [Sample source] |
---|---|---|---|---|
S51 | C51 | Biomuta | DOID:8618 / oral cavity cancer [ cosmic ] | |
S65 | F65 | Biomuta | DOID:4159 / skin cancer [ cosmic, icgc ] | |
S102 | L102 | Biomuta | DOID:363 / uterine cancer [ cosmic, icgc ] | |
S154 | F154 | Biomuta | DOID:4159 / skin cancer [ cosmic ] | |
S161 | F161 | Biomuta | DOID:4159 / skin cancer [ cosmic ] | |
S165 | L165 | Biomuta | DOID:3571 / liver cancer [ cosmic, icgc ] | |
R211 | K211 | Biomuta | DOID:4159 / skin cancer [ cosmic ] | |
R235 | Q235 | Biomuta | DOID:363 / uterine cancer [ icgc ] | |
R235 | W235 | Biomuta | DOID:1612 / breast cancer [ cosmic, icgc ] | |
R270 | W270 | Biomuta | DOID:184 / bone cancer [ cosmic ] DOID:3571 / liver cancer [ cosmic ] | |
S352 | F352 | Biomuta | DOID:4159 / skin cancer [ cosmic, icgc ] | |
S580 | L580 | Biomuta | DOID:363 / uterine cancer [ cosmic, icgc ] |