iPTMnet Report for Q9NRC8 (SIRT7)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9NRC8 / SIR7_HUMAN
Protein Name NAD-dependent protein deacetylase sirtuin-7
Gene Name Name: SIRT7
Synonyms:SIR2L7;
Organism Homo sapiens (Human)

PRO ID PR:Q9NRC8
DAG View
PRO Name NAD-dependent protein deacetylase sirtuin-7 (human)
Definition An NAD-dependent protein deacetylase sirtuin-7 that is encoded in the genome of human.
Short Label hSIRT7
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9NRC8 (SIRT7) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
R11 Methylation PhosphoSitePlus
S94 Phosphorylation PhosphoSitePlus
K131 Ubiquitination PhosphoSitePlus
S134 Phosphorylation PhosphoSitePlus
S136 O-Glycosylation GlyGen 35422493, 35625898, 29351928
S136 Phosphorylation PhosphoSitePlus
T153 Phosphorylation PhosphoSitePlus
C266 Methylation IEDB 31844290
S342 O-Glycosylation GlyGen 35422493, 35625898, 29351928
T345 O-Glycosylation GlyGen 35422493, 35625898, 29351928
S359 Phosphorylation PhosphoSitePlus
S363 Phosphorylation PhosphoSitePlus
R388 Methylation PhosphoSitePlus   UniProt 24129315, 30420520


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
R11 C11 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
K131 N131 Biomuta DOID:1319 / brain cancer [ cosmic ]
S136 I136 Biomuta DOID:4159 / skin cancer [ cosmic ]
S342 * Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:5041 / esophageal cancer [ cosmic ]
S359 W359 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
S359 L359 Biomuta DOID:363 / uterine cancer [ icgc ] DOID:1319 / brain cancer [ cosmic, icgc ]