iPTMnet Report for Q9NR45 (NANS)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9NR45 / SIAS_HUMAN
Protein Name Sialic acid synthase
Gene Name Name: NANS
Synonyms:SAS;
Organism Homo sapiens (Human)

PRO ID PR:Q9NR45
DAG View
PRO Name sialic acid synthase (human)
Definition A sialic acid synthase that is encoded in the genome of human.
Short Label hNANS
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9NR45 (NANS) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
C8 Methylation IEDB 31844290
K52 Acetylation PhosphoSitePlus
K52 Ubiquitination PhosphoSitePlus
K55 Ubiquitination PhosphoSitePlus
K61 Acetylation PhosphoSitePlus
K61 Ubiquitination PhosphoSitePlus
K65 Ubiquitination PhosphoSitePlus
Y71 Phosphorylation HPRD   PhosphoSitePlus 20068231
T72 Phosphorylation PhosphoSitePlus
S73 Phosphorylation PhosphoSitePlus
K74 Acetylation PhosphoSitePlus
K74 Ubiquitination PhosphoSitePlus
S76 Phosphorylation PhosphoSitePlus
K79 Acetylation PhosphoSitePlus   UniProt 19608861
K79 Ubiquitination PhosphoSitePlus
Y81 Phosphorylation PhosphoSitePlus
K85 Acetylation PhosphoSitePlus
S134 Phosphorylation PhosphoSitePlus
Y142 Phosphorylation PhosphoSitePlus
K145 Ubiquitination PhosphoSitePlus
T164 Phosphorylation PhosphoSitePlus
Y169 Phosphorylation PhosphoSitePlus
Y188 Phosphorylation PhosphoSitePlus
K243 Ubiquitination PhosphoSitePlus
K246 Ubiquitination PhosphoSitePlus
S248 Phosphorylation PhosphoSitePlus
S275 Phosphorylation HPRD   PhosphoSitePlus 20068231
T277 Phosphorylation PhosphoSitePlus
K278 Ubiquitination PhosphoSitePlus
K290 Acetylation PhosphoSitePlus
K290 Ubiquitination PhosphoSitePlus
K293 Ubiquitination PhosphoSitePlus
T305 Phosphorylation HPRD 20068231
K320 Ubiquitination PhosphoSitePlus
K333 Acetylation PhosphoSitePlus
K333 Ubiquitination PhosphoSitePlus
K355 Acetylation PhosphoSitePlus
K356 Acetylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K55 T55 Biomuta DOID:1319 / brain cancer [ cosmic, icgc ]
K55 N55 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S73 L73 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S76 P76 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
K79 E79 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
Y81 H81 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S134 F134 Biomuta DOID:4159 / skin cancer [ cosmic ]
T277 A277 Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
K290 N290 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
K293 T293 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]