iPTMnet Report Q9NR28 DIABLO

Protein Information

Cytoscape View

UniProt AC / UniProt ID	Q9NR28 / DBLOH_HUMAN
Protein Name	Diablo IAP-binding mitochondrial protein precursor
Gene Name	Name: DIABLO Synonyms:SMAC;
Organism	Homo sapiens (Human)

PRO ID	PR:Q9NR28 DAG View
PRO Name	diablo IAP-binding mitochondrial protein (human)
Definition	A diablo IAP-binding mitochondrial protein that is encoded in the genome of human.
Short Label	hDIABLO
Category	organism-gene

Interactive Sequence View

	Select/align proteoforms across species

Q9NR28 (DIABLO) as Substrate

Condensed View

	Site	PTM Type	PTM Enzyme	Score	Source	PMID
	S6	Phosphorylation		score3	PhosphoSitePlus RLIMS-P	25310587
	S6	Phosphorylation	P45983 (MAPK8)	score2	PhosphoSitePlus	25310587
	S9	Phosphorylation		score2	PhosphoSitePlus	25310587
	S9	Phosphorylation	P45983 (MAPK8)	score2	PhosphoSitePlus	25310587
	S11	Phosphorylation		score1	PhosphoSitePlus
	T13	Phosphorylation		score1	PhosphoSitePlus
	K62	Ubiquitination		score1	PhosphoSitePlus
	S67	Phosphorylation		score4	PhosphoSitePlus RLIMS-P	26458825, 24038446
	S67	Phosphorylation	P31749 (AKT1)	score2	PhosphoSitePlus	24038446
	K123	Ubiquitination		score1	PhosphoSitePlus
	S126	Phosphorylation		score1	PhosphoSitePlus
	K146	Acetylation		score1	PhosphoSitePlus
	K146	Ubiquitination		score1	PhosphoSitePlus
	K191	Ubiquitination		score1	PhosphoSitePlus
	K203	Ubiquitination		score1	PhosphoSitePlus
	K207	Ubiquitination		score1	PhosphoSitePlus
	K219	Ubiquitination		score1	PhosphoSitePlus
	T220	Phosphorylation		score1	PhosphoSitePlus
	S230	Phosphorylation		score1	PhosphoSitePlus

	Site	PTM Type	PTM Enzyme	Score	Source	PMID
	M1	Acetylation		score1	PRO

Proteoforms

	PRO ID (Short Label)	Sites	PTM Enzyme	Source	PMID
	PR:000036235 (hDIABLO/Ac:1)	acM1		PRO

PTM-dependent PPI

	PTM type	Substrate	Site	Interactant	Association type	Source	PMID
	Phosphorylation	Q9NR28 (DIABLO)	S67	P98170 (XIAP)	increased_association	eFIP	24038446

Proteoform PPIs

	Protein 1	Relation	Protein 2	Source	PMID
	PR:Q9NR28-1 (hDIABLO/iso:1)	Interaction	PR:O15392 (hBIRC5)	PRO	12660240
	PR:Q9NR28-1 (hDIABLO/iso:1)	Interaction	PR:P98170 (hXIAP)	PRO	12660240

PTM sites affected in variants

Site	Variant	Source	PMID	Disease [Sample source]
S230	P230	Biomuta		DOID:363 / uterine cancer [ cosmic ]