iPTMnet Report for Q9NQC1 (JADE2)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9NQC1 / JADE2_HUMAN
Protein Name E3 ubiquitin-protein ligase Jade-2
Gene Name Name: JADE2
Synonyms:KIAA0239,PHF15;
Organism Homo sapiens (Human)

PRO ID PR:Q9NQC1
DAG View
PRO Name E3 ubiquitin-protein ligase Jade-2 (human)
Definition An E3 ubiquitin-protein ligase Jade-2 that is encoded in the genome of human.
Short Label hJADE2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9NQC1 (JADE2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S9 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163
S11 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S12 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S15 Phosphorylation PhosphoSitePlus   UniProt 24275569
S20 Phosphorylation PhosphoSitePlus
S31 Phosphorylation PhosphoSitePlus
K32 Acetylation PhosphoSitePlus   UniProt 19608861
K38 Acetylation PhosphoSitePlus   UniProt 19608861
T121 Phosphorylation PhosphoSitePlus
K253 Ubiquitination PhosphoSitePlus
K298 Acetylation PhosphoSitePlus   UniProt 19608861
K356 Ubiquitination PhosphoSitePlus
K358 Ubiquitination PhosphoSitePlus
T374 Phosphorylation PhosphoSitePlus
S381 Phosphorylation PhosphoSitePlus
K389 Ubiquitination PhosphoSitePlus
T391 Phosphorylation PhosphoSitePlus
T445 Phosphorylation PhosphoSitePlus
K447 Ubiquitination PhosphoSitePlus
T448 Phosphorylation PhosphoSitePlus
Y484 Phosphorylation PhosphoSitePlus
S635 Phosphorylation PhosphoSitePlus
K637 Acetylation PhosphoSitePlus
S652 Phosphorylation PhosphoSitePlus
S657 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S9 Phosphorylation HPRD 18669648
S11 Phosphorylation HPRD 18669648
S12 Phosphorylation HPRD 18669648


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S9 Y9 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S31 A31 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S31 P31 Biomuta DOID:1319 / brain cancer [ cosmic ]