iPTMnet Report for Q9HCK5 (AGO4)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9HCK5 / AGO4_HUMAN
Protein Name Protein argonaute-4
Gene Name Name: AGO4
Synonyms:EIF2C4,KIAA1567;
Organism Homo sapiens (Human)

PRO ID PR:Q9HCK5
DAG View
PRO Name protein argonaute-4 (human)
Definition A protein argonaute-4 that is encoded in the genome of human.
Short Label hAGO4
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9HCK5 (AGO4) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S11 Phosphorylation PhosphoSitePlus
Y47 Phosphorylation PhosphoSitePlus
T108 Phosphorylation PhosphoSitePlus
K325 Ubiquitination PhosphoSitePlus
T327 Phosphorylation PhosphoSitePlus
Y328 Phosphorylation PhosphoSitePlus
K345 Ubiquitination PhosphoSitePlus
S352 Phosphorylation PhosphoSitePlus
K356 Ubiquitination PhosphoSitePlus
K374 Ubiquitination PhosphoSitePlus
Y412 Phosphorylation PhosphoSitePlus
K460 Ubiquitination PhosphoSitePlus
K471 Ubiquitination PhosphoSitePlus
T518 Phosphorylation PhosphoSitePlus
K525 Ubiquitination PhosphoSitePlus
K546 Ubiquitination PhosphoSitePlus
K558 Ubiquitination PhosphoSitePlus
K562 Sumoylation PhosphoSitePlus
K657 Ubiquitination PhosphoSitePlus
S798 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 16094384


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S11 T11 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
K374 N374 Biomuta DOID:4606 / bile duct cancer [ cosmic ]
K562 R562 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]