iPTMnet Report for Q9HCE7 (SMURF1)
Protein Information
UniProt AC / UniProt ID | Q9HCE7 / SMUF1_HUMAN |
Protein Name | E3 ubiquitin-protein ligase SMURF1 |
Gene Name | Name: SMURF1 Synonyms:KIAA1625; |
Organism | Homo sapiens (Human) |
PRO ID | PR:Q9HCE7 |
PRO Name | E3 ubiquitin-protein ligase SMURF1 (human) |
Definition | An E3 ubiquitin-protein ligase SMURF1 that is encoded in the genome of human. |
Short Label | hSMURF1 |
Category | organism-gene |
Q9HCE7 (SMURF1) as Substrate
Site | PTM Type | PTM Enzyme | Score | Source | PMID | |
---|---|---|---|---|---|---|
Y66 | Phosphorylation | score1 | PhosphoSitePlus | |||
Y69 | Phosphorylation | score1 | PhosphoSitePlus | |||
T145 | Phosphorylation | score0 | RLIMS-P | 27036023 | ||
S148 | Phosphorylation | score1 | PhosphoSitePlus | |||
S200 | Phosphorylation | score2 | PhosphoSitePlus UniProt | 23186163 | ||
T223 | Phosphorylation | score1 | PhosphoSitePlus | |||
S233 | Phosphorylation | score1 | PhosphoSitePlus | |||
Y251 | Phosphorylation | score1 | PhosphoSitePlus | |||
S260 | Phosphorylation | score1 | PhosphoSitePlus | |||
T332 | Phosphorylation | score1 | PhosphoSitePlus | |||
K350 | Ubiquitination | score1 | PhosphoSitePlus | |||
K381 | Ubiquitination | score3 | PhosphoSitePlus UniProt | 21572392 | ||
K383 | Ubiquitination | score3 | PhosphoSitePlus UniProt | 21572392 | ||
S412 | Phosphorylation | score1 | PhosphoSitePlus | |||
Y413 | Phosphorylation | score1 | PhosphoSitePlus | |||
K418 | Ubiquitination | score1 | PhosphoSitePlus | |||
Y440 | Phosphorylation | score1 | PhosphoSitePlus | |||
K521 | Ubiquitination | score1 | PhosphoSitePlus | |||
S656 | Phosphorylation | score1 | PhosphoSitePlus | |||
K739 | Ubiquitination | score1 | PhosphoSitePlus |
PTM-dependent PPI
PTM type | Substrate | Site | Interactant | Association type | Source | PMID | |
---|---|---|---|---|---|---|---|
Phosphorylation | Q9HCE7 (SMURF1) | T145 | Q5VWQ8 (DAB2IP) | unknown | eFIP | 27036023 |
Proteoform PPIs
Protein 1 | Relation | Protein 2 | Source | PMID | |
---|---|---|---|---|---|
PR:Q9HCE7-2 (hSMURF1/iso:Short) | Interaction | PRO | 11278251, 16299379 |
PTM sites affected in variants
Site | Variant | Source | PMID | Disease [Sample source] |
---|---|---|---|---|
Y69 | H69 | Biomuta | DOID:363 / uterine cancer [ cosmic, icgc ] | |
S148 | L148 | Biomuta | [ cosmic ] | |
T223 | K223 | Biomuta | DOID:3571 / liver cancer [ cosmic ] | |
T223 | M223 | Biomuta | DOID:363 / uterine cancer [ cosmic, icgc ] DOID:10283 / prostate cancer [ cosmic, icgc ] | |
K521 | T521 | Biomuta | DOID:3571 / liver cancer [ cosmic ] |