iPTMnet Report for Q9HCD5 (NCOA5)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9HCD5 / NCOA5_HUMAN
Protein Name Nuclear receptor coactivator 5
Gene Name Name: NCOA5
Synonyms:KIAA1637;
Organism Homo sapiens (Human)

PRO ID PR:Q9HCD5
DAG View
PRO Name nuclear receptor coactivator 5 (human)
Definition A nuclear receptor coactivator 5 that is encoded in the genome of human.
Short Label hNCOA5
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9HCD5 (NCOA5) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
M1 Acetylation UniProt 19413330, 21406692, 20068231
T3 Phosphorylation HPRD   PhosphoSitePlus   UniProt 19413330, 19651622, 20068231
S6 Phosphorylation HPRD   PhosphoSitePlus 19651622, 17081983, 20068231
S9 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 19413330, 21406692, 23186163, ...17081983, 19651622, 20068231
T11 Phosphorylation HPRD   PhosphoSitePlus 17081983
R13 Methylation PhosphoSitePlus
S21 Phosphorylation PhosphoSitePlus   UniProt 23186163
S24 Phosphorylation PhosphoSitePlus   UniProt 23186163
S29 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 19651622, 23186163, 17081983, ...20068231
S34 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 19651622, 23186163, 17081983, ...20068231
S51 Phosphorylation PhosphoSitePlus
S66 Phosphorylation PhosphoSitePlus
S75 Phosphorylation PhosphoSitePlus
S96 Phosphorylation PhosphoSitePlus   UniProt 23186163
Y107 Phosphorylation PhosphoSitePlus
S116 Phosphorylation PhosphoSitePlus   UniProt 23186163
S126 Phosphorylation HPRD   PhosphoSitePlus   UniProt 21406692, 23186163, 20068231
Y127 Phosphorylation HPRD   phospho.ELM 17081983
Y136 Phosphorylation PhosphoSitePlus
S143 Phosphorylation PhosphoSitePlus   UniProt 23186163
Y144 Phosphorylation PhosphoSitePlus
S151 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 23186163, 17081983, 20068231
S162 Phosphorylation PhosphoSitePlus
S164 Phosphorylation PhosphoSitePlus
Y184 Phosphorylation PhosphoSitePlus
S215 Phosphorylation PhosphoSitePlus
C266 Methylation IEDB 31844290
T267 Phosphorylation HPRD 20068231
T274 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 23186163, 20068231, 18220336
K362 Ubiquitination PhosphoSitePlus
S377 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18669648, 17287340, 20068231
S378 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 20068231
T379 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 19413330, 18669648, 23186163, ...20068231
S381 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 19413330, 21406692, 23186163, ...18669648, 24275569, 19690332, 20068231
S387 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 17287340
T394 O-Glycosylation GlyGen 32574038
T394 Phosphorylation PhosphoSitePlus
S395 O-Glycosylation GlyGen 23301498, 33214551, 35138101, ...30379171, 32574038, 35254053, 34019948, 30059200, 35132862, 31492838, 32119511, 35289036, 29351928, 22121020, 29237092
S395 Phosphorylation PhosphoSitePlus
S398 Phosphorylation PhosphoSitePlus
T401 O-Glycosylation GlyGen 23301498, 33214551, 35138101, ...30379171, 32574038, 35254053, 34019948, 30059200, 35132862, 31492838, 32119511, 35289036, 29351928, 22121020, 29237092
S404 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 16094384
S410 O-Glycosylation GlyGen 23301498, 33214551, 35138101, ...30379171, 32574038, 35254053, 34019948, 30059200, 35132862, 31492838, 32119511, 35289036, 29351928, 22121020, 29237092
S416 O-Glycosylation GlyGen 23301498, 33214551, 35138101, ...30379171, 32574038, 35254053, 34019948, 30059200, 35132862, 31492838, 32119511, 35289036, 29351928, 22121020, 29237092
T418 O-Glycosylation GlyGen 23301498, 33214551, 35138101, ...30379171, 32574038, 35254053, 34019948, 30059200, 35132862, 31492838, 32119511, 35289036, 29351928, 22121020, 29237092
T418 Phosphorylation PhosphoSitePlus
T420 O-Glycosylation GlyGen 23301498, 33214551, 35138101, ...30379171, 32574038, 35254053, 34019948, 30059200, 35132862, 31492838, 32119511, 35289036, 29351928, 22121020, 29237092
T420 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 16094384
S422 O-Glycosylation GlyGen 23301498, 33214551, 35138101, ...30379171, 32574038, 35254053, 34019948, 30059200, 35132862, 31492838, 32119511, 35289036, 29351928, 22121020, 29237092
T426 O-Glycosylation GlyGen 23301498, 33214551, 35138101, ...30379171, 32574038, 35254053, 34019948, 30059200, 35132862, 31492838, 32119511, 35289036, 29351928, 22121020, 29237092
S427 O-Glycosylation GlyGen 23301498, 33214551, 35138101, ...30379171, 32574038, 35254053, 34019948, 30059200, 35132862, 31492838, 32119511, 35289036, 29351928, 22121020, 29237092
S437 O-Glycosylation GlyGen 23301498, 33214551, 35138101, ...30379171, 32574038, 35254053, 34019948, 30059200, 35132862, 31492838, 32119511, 35289036, 29351928, 22121020, 29237092
S449 O-Glycosylation GlyGen 23301498, 33214551, 35138101, ...30379171, 32574038, 35254053, 34019948, 30059200, 35132862, 31492838, 32119511, 35289036, 29351928, 22121020, 29237092
S450 O-Glycosylation GlyGen 23301498, 33214551, 35138101, ...30379171, 32574038, 35254053, 34019948, 30059200, 35132862, 31492838, 32119511, 35289036, 29351928, 22121020, 29237092
S454 O-Glycosylation GlyGen 23301498, 33214551, 35138101, ...30379171, 32574038, 35254053, 34019948, 30059200, 35132862, 31492838, 32119511, 35289036, 29351928, 22121020, 29237092
T460 O-Glycosylation GlyGen 23301498, 33214551, 35138101, ...30379171, 32574038, 35254053, 34019948, 30059200, 35132862, 31492838, 32119511, 35289036, 29351928, 22121020, 29237092
S471 O-Glycosylation GlyGen 23301498, 33214551, 35138101, ...30379171, 32574038, 35254053, 34019948, 30059200, 35132862, 31492838, 32119511, 35289036, 29351928, 22121020, 29237092
S477 Phosphorylation PhosphoSitePlus
R500 Methylation PhosphoSitePlus
S505 Phosphorylation PhosphoSitePlus
R515 Methylation PhosphoSitePlus
S524 O-Glycosylation GlyGen 23301498, 33214551, 35138101, ...30379171, 32574038, 35254053, 34019948, 30059200, 35132862, 31492838, 32119511, 35289036, 29351928, 22121020, 29237092
S529 O-Glycosylation GlyGen 23301498, 33214551, 35138101, ...30379171, 32574038, 35254053, 34019948, 30059200, 35132862, 31492838, 32119511, 35289036, 29351928, 22121020, 29237092
S529 Phosphorylation PhosphoSitePlus
S530 O-Glycosylation GlyGen 23301498, 33214551, 35138101, ...30379171, 32574038, 35254053, 34019948, 30059200, 35132862, 31492838, 32119511, 35289036, 29351928, 22121020, 29237092
T546 Phosphorylation HPRD 20068231
T562 Phosphorylation HPRD 20068231


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
T3 M3 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ] DOID:9256 / colorectal cancer [ cosmic, icgc ]
T3 A3 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S21 G21 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S29 F29 Biomuta [ cosmic ]
S143 C143 Biomuta DOID:4362 / cervical cancer [ cosmic, icgc ]
S215 F215 Biomuta DOID:4159 / skin cancer [ cosmic ]
T379 I379 Biomuta DOID:263 / kidney cancer [ cosmic, icgc ]
T379 A379 Biomuta DOID:10534 / stomach cancer [ cosmic ]
S395 L395 Biomuta DOID:363 / uterine cancer [ icgc ]
T401 S401 Biomuta DOID:10534 / stomach cancer [ cosmic ]
T420 S420 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ]
S450 Y450 Biomuta DOID:363 / uterine cancer [ icgc ]
S454 L454 Biomuta DOID:2531 / hematologic cancer [ cosmic, icgc ]
S477 P477 Biomuta DOID:10534 / stomach cancer [ cosmic ]
S530 C530 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
T546 I546 Biomuta DOID:363 / uterine cancer [ icgc ]