iPTMnet Report for Q9HC62 (SENP2)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9HC62 / SENP2_HUMAN
Protein Name Sentrin-specific protease 2
Gene Name Name: SENP2
Synonyms:KIAA1331;
Organism Homo sapiens (Human)

PRO ID PR:Q9HC62
DAG View
PRO Name sentrin-specific protease 2 (human)
Definition A sentrin-specific protease 2 that is encoded in the genome of human.
Short Label hSENP2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9HC62 (SENP2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S32 Phosphorylation PhosphoSitePlus   UniProt 23186163
S34 Phosphorylation PhosphoSitePlus
T35 Phosphorylation PhosphoSitePlus
K48 Sumoylation PhosphoSitePlus
S123 Phosphorylation PhosphoSitePlus
Y130 Phosphorylation PhosphoSitePlus
S168 Phosphorylation PhosphoSitePlus
Y216 Phosphorylation phospho.ELM   PhosphoSitePlus 17287340
K224 Ubiquitination PhosphoSitePlus
S231 Phosphorylation PhosphoSitePlus
Y239 Phosphorylation PhosphoSitePlus
K253 Acetylation PhosphoSitePlus
K264 Acetylation PhosphoSitePlus
K271 Acetylation PhosphoSitePlus
K271 Ubiquitination PhosphoSitePlus
S284 Phosphorylation PhosphoSitePlus
S287 Phosphorylation PhosphoSitePlus
S292 Phosphorylation PhosphoSitePlus
S333 Phosphorylation PhosphoSitePlus   UniProt 23186163
S344 Phosphorylation O14757 (CHEK1) PhosphoSitePlus   UniProt 21851590, 23186163, 24275569
T348 Phosphorylation PhosphoSitePlus
T369 Phosphorylation Q15418 (RPS6KA1) PhosphoSitePlus 25689261
K447 Sumoylation PhosphoSitePlus
K455 Ubiquitination PhosphoSitePlus
Y493 Phosphorylation PhosphoSitePlus
S496 Phosphorylation PhosphoSitePlus
C505 Methylation IEDB 31844290
Y558 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
Y216 Phosphorylation HPRD 17287340
S333 Phosphorylation HPRD 19413330


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S34 C34 Biomuta DOID:4606 / bile duct cancer [ cosmic ]
S123 Y123 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
K271 E271 Biomuta DOID:10534 / stomach cancer [ cosmic ]
S496 F496 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S496 Y496 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]