iPTMnet Report for Q9HC52 (CBX8)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9HC52 / CBX8_HUMAN
Protein Name Chromobox protein homolog 8
Gene Name Name: CBX8
Synonyms:PC3,RC1;
Organism Homo sapiens (Human)

PRO ID PR:Q9HC52
DAG View
PRO Name chromobox protein homolog 8 (human)
Definition A chromobox protein homolog 8 that is encoded in the genome of human.
Short Label hCBX8
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9HC52 (CBX8) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S4 Phosphorylation HPRD 19007248
Y28 Phosphorylation PhosphoSitePlus
K33 Ubiquitination PhosphoSitePlus
K70 Ubiquitination PhosphoSitePlus
R103 Methylation PhosphoSitePlus
S110 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 18691976, 23186163, 19007248, ...19691289, 19651622, 18669648, 20068231
S130 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 18669648, 20068231
S190 Phosphorylation HPRD   PhosphoSitePlus 17081983
S191 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 19651622, 17081983, 20068231
S196 Phosphorylation PhosphoSitePlus
K205 Ubiquitination PhosphoSitePlus
K227 Ubiquitination PhosphoSitePlus
T234 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18669648, 20068231
K240 Acetylation PhosphoSitePlus
S256 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 23186163, 18669648, 24275569, ...19690332, 20068231
T264 Phosphorylation PhosphoSitePlus
S265 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 18691976, 18669648, 23186163, ...20068231
S268 Phosphorylation PhosphoSitePlus
K295 Ubiquitination PhosphoSitePlus
T305 Phosphorylation PhosphoSitePlus
S311 Phosphorylation HPRD   PhosphoSitePlus   UniProt 19651622, 23186163, 24275569
S315 Phosphorylation PhosphoSitePlus
Y321 Phosphorylation PhosphoSitePlus
S332 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 23186163, 18220336, 19691289, ...18669648, 20068231
S352 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 18669648, 20068231
S354 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18669648
K386 Ubiquitination PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K70 R70 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
K70 N70 Biomuta DOID:363 / uterine cancer [ icgc ]
R103 Q103 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S110 L110 Biomuta DOID:1319 / brain cancer [ cosmic, icgc ]
S196 * Biomuta DOID:1781 / thyroid gland cancer [ cosmic ]
K227 E227 Biomuta DOID:10283 / prostate cancer [ cosmic ]
S268 * Biomuta DOID:4159 / skin cancer [ cosmic ]
T305 P305 Biomuta DOID:1612 / breast cancer [ cosmic ]
S315 N315 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
S332 C332 Biomuta DOID:1319 / brain cancer [ cosmic, icgc ]
S332 F332 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S352 T352 Biomuta DOID:5041 / esophageal cancer [ cosmic ]