iPTMnet Report for Q9HC35 (EML4)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9HC35 / EMAL4_HUMAN
Protein Name Echinoderm microtubule-associated protein-like 4
Gene Name Name: EML4
Synonyms:C2orf2,EMAPL4;
Organism Homo sapiens (Human)

PRO ID PR:Q9HC35
DAG View
PRO Name echinoderm microtubule-associated protein-like 4 (human)
Definition An echinoderm microtubule-associated protein-like 4 that is encoded in the genome of human.
Short Label hEML4
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9HC35 (EML4) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
M1 Acetylation UniProt 22814378, 20068231
S7 Phosphorylation PhosphoSitePlus   UniProt 20068231
S11 Phosphorylation PhosphoSitePlus
S13 Phosphorylation PhosphoSitePlus   UniProt 20068231
S16 Phosphorylation PhosphoSitePlus   UniProt 20068231
T17 Phosphorylation PhosphoSitePlus
S18 Phosphorylation PhosphoSitePlus
S25 Phosphorylation PhosphoSitePlus
S29 Phosphorylation PhosphoSitePlus
K42 Ubiquitination PhosphoSitePlus
R50 Methylation PhosphoSitePlus
S61 Phosphorylation PhosphoSitePlus   UniProt 23186163, 20068231
K63 Ubiquitination PhosphoSitePlus
S65 Phosphorylation PhosphoSitePlus
S68 Phosphorylation PhosphoSitePlus
K69 Ubiquitination PhosphoSitePlus
S73 Phosphorylation PhosphoSitePlus
S81 Phosphorylation PhosphoSitePlus
S87 Phosphorylation phospho.ELM 17081983
K92 Ubiquitination PhosphoSitePlus
S94 Phosphorylation PhosphoSitePlus
T96 Phosphorylation PhosphoSitePlus   UniProt 24275569
S100 Phosphorylation PhosphoSitePlus
S108 Phosphorylation PhosphoSitePlus
S109 Phosphorylation PhosphoSitePlus
S132 Phosphorylation PhosphoSitePlus
S134 Phosphorylation PhosphoSitePlus   UniProt 31409757
S138 Phosphorylation PhosphoSitePlus
S144 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 23186163, 17081983, ...18220336, 31409757, 18669648, 20068231
S146 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 23186163, 17081983, ...18220336, 31409757, 18669648
S150 Phosphorylation PhosphoSitePlus
S151 Phosphorylation PhosphoSitePlus
T160 Phosphorylation PhosphoSitePlus
S163 Phosphorylation PhosphoSitePlus
K170 Acetylation PhosphoSitePlus
S171 Phosphorylation PhosphoSitePlus   UniProt 23186163
K173 Acetylation PhosphoSitePlus
S176 Phosphorylation PhosphoSitePlus
S184 Phosphorylation PhosphoSitePlus
S191 Phosphorylation PhosphoSitePlus
S200 Phosphorylation PhosphoSitePlus   UniProt 23186163
T201 Phosphorylation PhosphoSitePlus   UniProt 23186163
T209 Phosphorylation PhosphoSitePlus
T211 Phosphorylation PhosphoSitePlus
K216 Ubiquitination PhosphoSitePlus
Y226 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 15592455, 18083107
T237 Phosphorylation PhosphoSitePlus   UniProt 24275569
S242 Phosphorylation PhosphoSitePlus
Y247 Phosphorylation PhosphoSitePlus
Y265 Phosphorylation PhosphoSitePlus
Y267 Phosphorylation PhosphoSitePlus
Y297 Phosphorylation PhosphoSitePlus
Y305 Phosphorylation PhosphoSitePlus
T326 Phosphorylation PhosphoSitePlus
T437 Phosphorylation PhosphoSitePlus
Y453 Phosphorylation PhosphoSitePlus
T490 Phosphorylation PhosphoSitePlus   UniProt 31409757
K493 Ubiquitination PhosphoSitePlus
Y499 Phosphorylation phospho.ELM   PhosphoSitePlus 17081983
S502 Phosphorylation phospho.ELM   PhosphoSitePlus 17081983
K532 Ubiquitination PhosphoSitePlus
T609 Phosphorylation UniProt 31409757
C617 Methylation IEDB 31844290
Y743 Phosphorylation PhosphoSitePlus
K867 Ubiquitination PhosphoSitePlus
S869 O-Glycosylation GlyGen 23301498, 33214551, 34725712, ...35254053, 28510447, 28657654
S869 Phosphorylation PhosphoSitePlus
T875 Phosphorylation PhosphoSitePlus
T880 Phosphorylation PhosphoSitePlus
T882 O-Glycosylation GlyGen 23301498, 33214551, 34725712, ...35254053, 28510447, 28657654
T889 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S891 Phosphorylation PhosphoSitePlus   UniProt 24275569
S895 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648
T897 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 19690332
T899 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 23186163, 18220336, 15302935, ...18669648, 24275569, 19690332, 20068231
S903 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648
T909 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S919 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
T921 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S934 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S938 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S942 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S946 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
Y954 Phosphorylation PhosphoSitePlus
S978 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 18669648, 20068231
S980 Phosphorylation PhosphoSitePlus
S981 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 31409757, 18669648
Site PTM Type PTM Enzyme Score Source PMID
S7 Phosphorylation HPRD 20068231
S11 Phosphorylation HPRD 20068231
S13 Phosphorylation HPRD 20068231
S16 Phosphorylation HPRD 19007248, 20068231
T17 Phosphorylation HPRD 20068231
S61 Phosphorylation HPRD 20068231
S87 Phosphorylation HPRD 17081983
S134 Phosphorylation HPRD 17081983, 20068231
S138 Phosphorylation HPRD 17081983, 20068231, 19007248
S144 Phosphorylation HPRD 17081983, 19691289, 19651622, ...18669648, 20166139, 20068231
S146 Phosphorylation HPRD 17322306, 18491316, 19691289, ...19651622, 18669648, 20166139, 20068231
S150 Phosphorylation HPRD 19651622
S176 Phosphorylation HPRD 20068231
S200 Phosphorylation HPRD 20166139
T201 Phosphorylation HPRD 19413330, 20166139
Y226 Phosphorylation HPRD 15592455, 18083107
T889 Phosphorylation HPRD 18669648
S895 Phosphorylation HPRD 19413330, 18669648, 17081983, ...20068231
T897 Phosphorylation HPRD 19413330, 18669648, 17081983, ...20068231, 19415658
T899 Phosphorylation HPRD 19413330, 18669648, 15302935, ...19415658, 20068231
S903 Phosphorylation HPRD 18669648
T909 Phosphorylation HPRD 18669648
S919 Phosphorylation HPRD 18669648
T921 Phosphorylation HPRD 18669648
S934 Phosphorylation HPRD 18669648
S938 Phosphorylation HPRD 18669648
S942 Phosphorylation HPRD 18669648
S946 Phosphorylation HPRD 18669648
S978 Phosphorylation HPRD 19413330, 18669648, 19664995, ...20068231
S980 Phosphorylation HPRD 19664995
S981 Phosphorylation HPRD 18669648, 19664995, 20068231
Site PTM Type PTM Enzyme Score Source PMID
S94 Phosphorylation PhosphoSitePlus
S113 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S11 N11 Biomuta DOID:1319 / brain cancer [ cosmic ]
S18 F18 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S18 Y18 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
S29 * Biomuta DOID:263 / kidney cancer [ cosmic ]
S68 N68 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
K69 * Biomuta DOID:1612 / breast cancer [ cosmic ]
S100 * Biomuta DOID:9256 / colorectal cancer [ cosmic ] DOID:10283 / prostate cancer [ cosmic ]
S132 Y132 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ] DOID:9256 / colorectal cancer [ cosmic ]
S134 C134 Biomuta DOID:1324 / lung cancer [ cosmic ]
K173 Q173 Biomuta DOID:363 / uterine cancer [ icgc ]
S184 Y184 Biomuta DOID:1319 / brain cancer [ cosmic, icgc ]
S200 L200 Biomuta DOID:4159 / skin cancer [ cosmic ]
S200 * Biomuta DOID:4362 / cervical cancer [ cosmic ]
T211 S211 Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
T211 N211 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]
Y265 H265 Biomuta DOID:3277 / thymus cancer [ cosmic ]
Y499 C499 Biomuta DOID:3571 / liver cancer [ cosmic ]
Y499 N499 Biomuta DOID:4159 / skin cancer [ cosmic ]
K867 Q867 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ]
S869 F869 Biomuta DOID:4159 / skin cancer [ cosmic ]
T897 A897 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S978 L978 Biomuta DOID:9256 / colorectal cancer [ cosmic ] DOID:2531 / hematologic cancer [ icgc ]