iPTMnet Report for Q9HAU0 (PLEKHA5)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9HAU0 / PKHA5_HUMAN
Protein Name Pleckstrin homology domain-containing family A member 5
Gene Name Name: PLEKHA5
Synonyms:KIAA1686,PEPP2;
Organism Homo sapiens (Human)

PRO ID PR:Q9HAU0
DAG View
PRO Name pleckstrin homology domain-containing family A member 5 (human)
Definition A pleckstrin homology domain-containing family A member 5 that is encoded in the genome of human.
Short Label hPLEKHA5
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9HAU0 (PLEKHA5) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
A2 Acetylation UniProt 22223895
R22 Methylation PhosphoSitePlus
S55 Phosphorylation PhosphoSitePlus   UniProt 23186163
T56 Phosphorylation PhosphoSitePlus
S111 Phosphorylation PhosphoSitePlus
S120 Phosphorylation PhosphoSitePlus
S126 Phosphorylation PhosphoSitePlus
Y128 Phosphorylation PhosphoSitePlus
T131 Phosphorylation PhosphoSitePlus
S132 Phosphorylation PhosphoSitePlus
Y134 Phosphorylation PhosphoSitePlus
S140 Phosphorylation PhosphoSitePlus
T145 Phosphorylation PhosphoSitePlus
S159 Phosphorylation PhosphoSitePlus
S161 Phosphorylation PhosphoSitePlus
Y177 Phosphorylation PhosphoSitePlus
K275 Ubiquitination PhosphoSitePlus
K279 Ubiquitination PhosphoSitePlus
K301 Sumoylation PhosphoSitePlus
K326 Ubiquitination PhosphoSitePlus
Y327 Phosphorylation PhosphoSitePlus
S351 Phosphorylation PhosphoSitePlus
Y353 Phosphorylation PhosphoSitePlus
S357 Phosphorylation PhosphoSitePlus
T363 Phosphorylation PhosphoSitePlus
Y366 Phosphorylation PhosphoSitePlus
S374 Phosphorylation PhosphoSitePlus
S382 O-Glycosylation GlyGen   PhosphoSitePlus 23301498, 34846842, 32574038, ...34725712, 30059200, 28657654, 30620550, 35132862, 31492838, 35289036, 35254053, 21158410, 29237092, 20068230
S382 Phosphorylation PhosphoSitePlus   UniProt 23186163
T394 Phosphorylation PhosphoSitePlus
Y398 Phosphorylation PhosphoSitePlus
T399 O-Glycosylation GlyGen 23301498, 34846842, 32574038, ...34725712, 30059200, 28657654, 30620550, 35132862, 31492838, 35289036, 35254053, 21158410, 29237092, 20068230
T399 Phosphorylation PhosphoSitePlus
T408 Phosphorylation PhosphoSitePlus
S410 Phosphorylation PhosphoSitePlus   UniProt 23186163
R424 Methylation PhosphoSitePlus
S435 Phosphorylation PhosphoSitePlus
Y436 Phosphorylation PhosphoSitePlus
T438 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 23186163, 18220336
Y454 Phosphorylation PhosphoSitePlus
T460 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 23186163, 18220336
S471 Phosphorylation PhosphoSitePlus
S474 Phosphorylation PhosphoSitePlus
T476 Phosphorylation phospho.ELM   PhosphoSitePlus 18220336
T479 Phosphorylation phospho.ELM   PhosphoSitePlus 18220336
S494 Phosphorylation PhosphoSitePlus
T499 Phosphorylation PhosphoSitePlus
Y504 Phosphorylation PhosphoSitePlus
Y512 Phosphorylation PhosphoSitePlus
S526 Phosphorylation PhosphoSitePlus
T543 Phosphorylation PhosphoSitePlus
S549 Phosphorylation PhosphoSitePlus
Y553 Phosphorylation PhosphoSitePlus
S557 Phosphorylation PhosphoSitePlus
S564 Phosphorylation phospho.ELM   PhosphoSitePlus 18220336
S568 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 23186163, 16964243
T576 Phosphorylation PhosphoSitePlus
Y590 Phosphorylation PhosphoSitePlus
S596 Phosphorylation PhosphoSitePlus
S607 Phosphorylation PhosphoSitePlus   UniProt 23186163
S610 Phosphorylation PhosphoSitePlus
S617 Phosphorylation PhosphoSitePlus
S789 Phosphorylation PhosphoSitePlus
Y804 Phosphorylation PhosphoSitePlus
Y807 Phosphorylation PhosphoSitePlus
S809 Phosphorylation PhosphoSitePlus   UniProt 21406692, 23186163
S822 Phosphorylation PhosphoSitePlus
S828 Phosphorylation PhosphoSitePlus
S832 Phosphorylation PhosphoSitePlus
S837 Phosphorylation PhosphoSitePlus
S842 Phosphorylation PhosphoSitePlus
S855 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 21406692, ...17081983
T857 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648, 17081983
S860 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
T862 Phosphorylation PhosphoSitePlus
S865 Phosphorylation PhosphoSitePlus
Y866 Phosphorylation PhosphoSitePlus
T868 Phosphorylation PhosphoSitePlus
T872 Phosphorylation PhosphoSitePlus
S885 Phosphorylation IEDB   PhosphoSitePlus 30784271
S930 Phosphorylation PhosphoSitePlus
S933 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 23186163, 17081983, 18220336, ...18669648, 19690332
S937 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 17081983, ...18220336
S939 Phosphorylation PhosphoSitePlus
T974 Phosphorylation PhosphoSitePlus
S1003 Phosphorylation PhosphoSitePlus
Y1004 Phosphorylation PhosphoSitePlus
S1037 Phosphorylation PhosphoSitePlus
S1060 O-Glycosylation GlyGen 23301498, 34846842, 32574038, ...34725712, 30059200, 28657654, 30620550, 35132862, 31492838, 35289036, 35254053, 21158410, 29237092, 20068230
T1074 O-Glycosylation GlyGen 23301498, 34846842, 32574038, ...34725712, 30059200, 28657654, 30620550, 35132862, 31492838, 35289036, 35254053, 21158410, 29237092, 20068230
T1083 Phosphorylation PhosphoSitePlus
S1090 Phosphorylation PhosphoSitePlus
S1092 Phosphorylation PhosphoSitePlus
S1098 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
Y128 Phosphorylation HPRD 15951569
Y134 Phosphorylation HPRD 15951569
S410 Phosphorylation HPRD 19413330, 20058876
T438 Phosphorylation HPRD 18767875, 19664994, 18212344
S568 Phosphorylation HPRD 19664994, 16964243, 20068231
T576 Phosphorylation HPRD 18212344, 20068231
S607 Phosphorylation HPRD 19413330
S789 Phosphorylation HPRD 20068231
S809 Phosphorylation HPRD 19651622, 19664994
S855 Phosphorylation HPRD 17081983, 18767875, 19664994, ...18452278, 19651622, 18669648, 17693683, 20068231
T857 Phosphorylation HPRD 19651622, 18767875, 18669648, ...17081983
S860 Phosphorylation HPRD 18669648
S930 Phosphorylation HPRD 19413330
S933 Phosphorylation HPRD 19413330, 18669648, 17081983, ...20068231
S937 Phosphorylation HPRD 19413330, 18669648, 17081983, ...20068231
S939 Phosphorylation HPRD 17081983
Site PTM Type PTM Enzyme Score Source PMID
S607 Phosphorylation PhosphoSitePlus
S610 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
R22 S22 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ]
S111 F111 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
Y128 C128 Biomuta DOID:4159 / skin cancer [ cosmic ]
S140 G140 Biomuta DOID:10534 / stomach cancer [ cosmic ]
S159 L159 Biomuta DOID:363 / uterine cancer [ icgc ]
Y327 F327 Biomuta DOID:4606 / bile duct cancer [ cosmic ]
Y353 C353 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S374 L374 Biomuta DOID:10534 / stomach cancer [ cosmic ]
S382 T382 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S382 G382 Biomuta DOID:2531 / hematologic cancer [ icgc ]
R424 M424 Biomuta DOID:1319 / brain cancer [ cosmic, icgc ]
Y436 F436 Biomuta DOID:3571 / liver cancer [ cosmic ]
Y454 C454 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ]
T460 R460 Biomuta DOID:1319 / brain cancer [ cosmic, icgc ]
Y504 C504 Biomuta [ cosmic ]
S549 P549 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
Y553 S553 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S564 L564 Biomuta [ cosmic ] DOID:363 / uterine cancer [ icgc ] DOID:10534 / stomach cancer [ cosmic ] DOID:1115 / sarcoma [ icgc ] DOID:4159 / skin cancer [ cosmic ]
S607 G607 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
Y807 C807 Biomuta DOID:3953 / adrenal gland cancer [ cosmic ] DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]
S828 * Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
S828 L828 Biomuta DOID:4159 / skin cancer [ cosmic ]
S842 F842 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
Y866 C866 Biomuta DOID:263 / kidney cancer [ cosmic, icgc ]
S1037 I1037 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]