iPTMnet Report for Q9H6F5 (CCDC86)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9H6F5 / CCD86_HUMAN
Protein Name Coiled-coil domain-containing protein 86
Gene Name Name: CCDC86
Synonyms:CYCLON;
Organism Homo sapiens (Human)

PRO ID PR:Q9H6F5
DAG View
PRO Name coiled-coil domain-containing protein 86 (human)
Definition A coiled-coil domain-containing protein 86 that is encoded in the genome of human.
Short Label hCCDC86
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9H6F5 (CCDC86) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
T3 Phosphorylation PhosphoSitePlus
R15 Methylation PhosphoSitePlus
S18 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 23186163, 17081983, ...18220336, 16565220, 19367720, 18669648, 24275569, 19690332, 20068231, 17924679
S21 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 23186163, 17081983, 18220336, ...18669648, 19690332
T23 Phosphorylation phospho.ELM   PhosphoSitePlus 18220336
S24 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 18220336
S26 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648, 17081983, 18220336
R30 Methylation PhosphoSitePlus
S37 Phosphorylation PhosphoSitePlus
T42 Phosphorylation phospho.ELM   PhosphoSitePlus 17081983, 18220336
S47 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 23186163, 17081983, ...18220336, 18669648, 24275569, 19690332, 20068231
S50 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 19690332, 18669648, 17081983, ...18220336
S58 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 23186163, 17081983, ...18669648, 24275569, 20068231
T65 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 21406692, 20068231, ...17081983
S66 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 17081983
S69 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 17081983, ...20068231
S80 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 23186163, 17081983, ...18220336, 18669648, 19690332, 20068231, 16964243
S91 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 23186163, 17081983, ...18220336, 15302935, 18669648, 24275569, 19690332, 20068231, 16964243
S102 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 23186163, 17081983, ...18669648, 20068231
Y109 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S110 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 16565220
S113 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 23186163, 17081983, 16565220, ...18669648, 20068231
C127 Methylation IEDB 31844290
S128 Phosphorylation PhosphoSitePlus   UniProt 20068231
T146 Phosphorylation PhosphoSitePlus
S160 Phosphorylation PhosphoSitePlus
Y164 Phosphorylation PhosphoSitePlus
T182 Phosphorylation PhosphoSitePlus
S188 Phosphorylation phospho.ELM   PhosphoSitePlus 17081983
S196 Phosphorylation PhosphoSitePlus
K197 Ubiquitination PhosphoSitePlus
T206 Phosphorylation PhosphoSitePlus
K212 Acetylation PhosphoSitePlus
K213 Acetylation PhosphoSitePlus
S217 Phosphorylation PhosphoSitePlus   UniProt 21406692
S218 Phosphorylation PhosphoSitePlus
S219 Phosphorylation PhosphoSitePlus
S224 Phosphorylation PhosphoSitePlus
K225 Acetylation PhosphoSitePlus
S250 Phosphorylation PhosphoSitePlus
S255 Phosphorylation Q96GD4 (AURKB) PhosphoSitePlus 22267324
K261 Acetylation PhosphoSitePlus
K261 Ubiquitination PhosphoSitePlus
K281 Ubiquitination PhosphoSitePlus
K291 Ubiquitination PhosphoSitePlus
K315 Ubiquitination PhosphoSitePlus
K333 Methylation PhosphoSitePlus
S338 Phosphorylation phospho.ELM   PhosphoSitePlus 17081983
T344 Phosphorylation PhosphoSitePlus
K350 Ubiquitination PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
T3 Phosphorylation HPRD 20068231
S18 Phosphorylation HPRD 18212344, 20230923, 19562805, ...18767875, 16565220, 20058876, 19664995, 19691289, 19651622, 18669648, 18707149, 20166139, 19007248, 18452278, 19415658, 20068231, 17924679
S21 Phosphorylation HPRD 19651622, 18669648, 20068231
T23 Phosphorylation HPRD 20068231
S24 Phosphorylation HPRD 18669648, 20068231
S26 Phosphorylation HPRD 18669648, 20068231
T42 Phosphorylation HPRD 17081983, 20068231
S47 Phosphorylation HPRD 19664995, 17081983, 19562805, ...19007248, 18452278, 19651622, 18669648, 18707149, 19415658, 20068231, 19691289
S50 Phosphorylation HPRD 17081983, 19007248, 19651622, ...18669648, 19415658, 20068231
S58 Phosphorylation HPRD 19664995, 19691289, 18212344, ...18767875, 19007248, 18452278, 19651622, 18669648, 18707149, 19415658, 20068231, 20068230
T65 Phosphorylation HPRD 19651622, 18767875, 18669648, ...20068231
S66 Phosphorylation HPRD 19651622, 18767875, 18669648, ...19415658, 20068231
S69 Phosphorylation HPRD 19651622, 18669648, 19415658, ...20068231
S80 Phosphorylation HPRD 19413330, 16964243, 19664995, ...19007248, 19651622, 18669648, 19415658, 20068231
S91 Phosphorylation HPRD 19413330, 18491316, 16964243, ...20058876, 19664994, 19664995, 19007248, 19651622, 15302935, 18669648, 18452278, 19415658, 20068231, 19691289
S102 Phosphorylation HPRD 17081983, 19007248, 19691289, ...19651622, 18669648, 20068231
Y109 Phosphorylation HPRD 18669648
S110 Phosphorylation HPRD 19413330, 19007248, 16565220, ...19664995, 18669648, 20068231, 19691289
S113 Phosphorylation HPRD 19413330, 18212344, 19664995, ...16565220, 19651622, 20068231
S121 Phosphorylation HPRD 17081983
S128 Phosphorylation HPRD 19413330, 18077418, 20068231
Y164 Phosphorylation HPRD 20068231
T182 Phosphorylation HPRD 20068231
S188 Phosphorylation HPRD 17081983
S217 Phosphorylation HPRD 19651622
S218 Phosphorylation HPRD 19651622
S250 Phosphorylation HPRD 20068231
S255 Phosphorylation HPRD 20068231
S338 Phosphorylation HPRD 17081983


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S18 F18 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
S50 C50 Biomuta [ cosmic ]
S66 R66 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S80 L80 Biomuta DOID:4362 / cervical cancer [ cosmic, icgc ]
S102 P102 Biomuta DOID:3571 / liver cancer [ cosmic ]
Y109 C109 Biomuta DOID:4362 / cervical cancer [ icgc ]
S128 F128 Biomuta DOID:363 / uterine cancer [ icgc ]
K212 T212 Biomuta DOID:2394 / ovarian cancer [ cosmic, icgc ]
K225 N225 Biomuta DOID:9256 / colorectal cancer [ cosmic ]