iPTMnet Report for Q9H4B7 (TUBB1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9H4B7 / TBB1_HUMAN
Protein Name Tubulin beta-1 chain
Gene Name Name: TUBB1
Organism Homo sapiens (Human)

PRO ID PR:Q9H4B7
DAG View
PRO Name tubulin beta-1 chain (human)
Definition A tubulin beta-1 chain that is encoded in the genome of human.
Short Label hTUBB1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9H4B7 (TUBB1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
Y55 Phosphorylation PhosphoSitePlus
K58 Acetylation PhosphoSitePlus
K154 Ubiquitination PhosphoSitePlus
Y159 Phosphorylation PhosphoSitePlus
S168 Phosphorylation PhosphoSitePlus
S172 Phosphorylation UniProt 16371510
Y208 Phosphorylation PhosphoSitePlus
Y222 Phosphorylation PhosphoSitePlus
K252 Acetylation PhosphoSitePlus
K252 Sumoylation PhosphoSitePlus
K252 Ubiquitination PhosphoSitePlus
S278 Phosphorylation PhosphoSitePlus
Y281 Phosphorylation PhosphoSitePlus
K324 Acetylation PhosphoSitePlus
K390 Acetylation PhosphoSitePlus
T439 Phosphorylation HPRD   PhosphoSitePlus 20058876


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
Y55 H55 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
K154 M154 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S168 C168 Biomuta DOID:2394 / ovarian cancer [ cosmic ]
S172 F172 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:9256 / colorectal cancer [ cosmic ]
Y222 H222 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
Y281 * Biomuta DOID:1324 / lung cancer [ cosmic ]
T439 M439 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]