iPTMnet Report for Q9H4B4 (PLK3)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9H4B4 / PLK3_HUMAN
Protein Name Serine/threonine-protein kinase PLK3
Gene Name Name: PLK3
Synonyms:CNK,FNK,PRK;
Organism Homo sapiens (Human)

PRO ID PR:Q9H4B4
DAG View
PRO Name serine/threonine-protein kinase PLK3 (human)
Definition A serine/threonine-protein kinase PLK3 that is encoded in the genome of human.
Short Label hPLK3
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9H4B4 (PLK3) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
Y136 Phosphorylation PhosphoSitePlus
T194 Phosphorylation PhosphoSitePlus
T219 Phosphorylation PhosphoSitePlus   RLIMS-P 32575753
T348 O-Glycosylation GlyGen 30379171
T348 Phosphorylation Q9H4B4 (PLK3) neXtProt   PhosphoSitePlus 18413330, 19103756, 9353331
S433 Phosphorylation PhosphoSitePlus
T503 Phosphorylation PhosphoSitePlus
Y506 Phosphorylation PhosphoSitePlus
S510 Phosphorylation PhosphoSitePlus
S515 Phosphorylation PhosphoSitePlus
T614 Phosphorylation PhosphoSitePlus
Y615 Phosphorylation PhosphoSitePlus


Q9H4B4 (PLK3) as PTM Enzyme



Substrate Site Score Source PMID
O43852 (CALU) S44 PhosphoSitePlus 22828320
O43852 (CALU) T60 PhosphoSitePlus 22828320
O43852 (CALU) T177 PhosphoSitePlus 22828320
O43852 (CALU) T196 PhosphoSitePlus 22828320
O43852 (CALU) T254 PhosphoSitePlus 22828320
O96017 (CHEK2) S62 neXtProt   PhosphoSitePlus 16481012, 12242661, 21376736
O96017-12 (CHEK2) T68 HPRD 10973490, 11901158, 12493754, ...12242661
O96017 (CHEK2) S73 neXtProt   PhosphoSitePlus 16481012, 12242661, 21376736
P04637 (TP53) S20 HPRD   neXtProt   PhosphoSitePlus   Signor 12242661, 10673501, 11447225, ...12548019, 15671037, 11709713, 11551930
P05412 (JUN) S63 neXtProt   PhosphoSitePlus   Signor 17804415, 21296815, 18650425
P05412 (JUN) S73 neXtProt   PhosphoSitePlus   Signor 17804415, 21296815, 18650425
P06748 (NPM1) S4 PhosphoSitePlus 15190079
P08238 (HSP90AB1) S718 PhosphoSitePlus 22828320
P11388 (TOP2A) T1343 neXtProt   PhosphoSitePlus   Signor 18062778
P14635 (CCNB1) S133 PhosphoSitePlus 18062778
P15336 (ATF2) T69 PhosphoSitePlus   Signor 21098032, 20068231
P15336 (ATF2) T71 neXtProt   PhosphoSitePlus   Signor 21098032, 21296815, 20068231
P30304 (CDC25A) T80 PhosphoSitePlus   Signor 18167338
P30304 (CDC25A) S513 neXtProt 21376736
P30304 (CDC25A) S519 neXtProt 21376736
P30307 (CDC25C) S191 neXtProt   phospho.ELM   PhosphoSitePlus   Signor 14968113
P30307 (CDC25C) S198 neXtProt   phospho.ELM   PhosphoSitePlus   Signor 14968113, 18062778
P30307-1 (CDC25C) S216 HPRD   neXtProt 9543386, 10557092, 9278512, ...11333986, 11551930, 20068231
P37840 (SNCA) S129 neXtProt   PhosphoSitePlus   Signor 26807843, 19889641, 19004816
P60484 (PTEN) T366 neXtProt   PhosphoSitePlus   Signor 20940307
P60484 (PTEN) S370 neXtProt   PhosphoSitePlus   Signor 20940307
P62258 (YWHAE) T208 PhosphoSitePlus 22828320
Q07817 (BCL2L1) S49 neXtProt   PhosphoSitePlus   Signor 21840391, 21336504
Q16143 (SNCB) S118 neXtProt   PhosphoSitePlus   Signor 19889641
Q16665 (HIF1A) S576 neXtProt   PhosphoSitePlus   Signor 18519666, 20889502
Q16665 (HIF1A) S657 neXtProt   PhosphoSitePlus   Signor 18519666, 20889502
Q99986 (VRK1) S342 HPRD   neXtProt   PhosphoSitePlus   Signor 19103756, 20068231
Q9H4B4 (PLK3) T348 neXtProt 18413330, 19103756, 9353331


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
Y506 C506 Biomuta DOID:363 / uterine cancer [ icgc ]
S515 P515 Biomuta DOID:4362 / cervical cancer [ icgc ]
S515 F515 Biomuta DOID:4159 / skin cancer [ cosmic ]