Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9H4A3 / WNK1_HUMAN
Protein Name Serine/threonine-protein kinase WNK1
Gene Name Name: WNK1
Synonyms:HSN2;
Organism Homo sapiens (Human)

PRO ID PR:Q9H4A3
DAG View
PRO Name serine/threonine-protein kinase WNK1 (human)
Definition A serine/threonine-protein kinase WNK1 that is encoded in the genome of human.
Short Label hWNK1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9H4A3 (WNK1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S2 Phosphorylation PhosphoSitePlus
S10 O-Glycosylation GlyGen 23301498, 35138101, 30620550, ...31492838, 35289036, 29249144, 22661428, 29237092, 34725712, 31373491, 32119511, 30397120, 32574038, 35132862, 20305658, 29351928, 28657654, 27655845, 34846842, 33214551, 30379171, 30059200, 21740066, 35254053, 34019948, 36240223
S11 O-Glycosylation GlyGen 23301498, 35138101, 30620550, ...31492838, 35289036, 29249144, 22661428, 29237092, 34725712, 31373491, 32119511, 30397120, 32574038, 35132862, 20305658, 29351928, 28657654, 27655845, 34846842, 33214551, 30379171, 30059200, 21740066, 35254053, 34019948, 36240223
S11 Phosphorylation PhosphoSitePlus
T12 Phosphorylation PhosphoSitePlus
S15 Phosphorylation PhosphoSitePlus   UniProt 17190791
S19 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 20068231
S33 Phosphorylation PhosphoSitePlus
T60 Phosphorylation neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor 14611643, 16081417, 29930759, ...21355052
T60 Phosphorylation O00141 (SGK1) neXtProt   PhosphoSitePlus 21355052, 16081417
T60 Phosphorylation O75582 (RPS6KA5) PhosphoSitePlus 14611643
T60 Phosphorylation P31749 (AKT1) neXtProt   PhosphoSitePlus   Signor 14611643, 16081417
R66 Methylation PhosphoSitePlus
T71 O-Glycosylation GlyGen 23301498, 35138101, 30620550, ...31492838, 35289036, 29249144, 22661428, 29237092, 34725712, 31373491, 32119511, 30397120, 32574038, 35132862, 20305658, 29351928, 28657654, 27655845, 34846842, 33214551, 30379171, 30059200, 21740066, 35254053, 34019948, 36240223
T73 O-Glycosylation GlyGen 23301498, 35138101, 30620550, ...31492838, 35289036, 29249144, 22661428, 29237092, 34725712, 31373491, 32119511, 30397120, 32574038, 35132862, 20305658, 29351928, 28657654, 27655845, 34846842, 33214551, 30379171, 30059200, 21740066, 35254053, 34019948, 36240223
T74 Phosphorylation PhosphoSitePlus
S167 O-Glycosylation GlyGen 23301498, 35138101, 30620550, ...31492838, 35289036, 29249144, 22661428, 29237092, 34725712, 31373491, 32119511, 30397120, 32574038, 35132862, 20305658, 29351928, 28657654, 27655845, 34846842, 33214551, 30379171, 30059200, 21740066, 35254053, 34019948, 36240223
S167 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 17525332, 23186163, 24275569, ...17190791
S170 Phosphorylation PhosphoSitePlus
S174 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 17525332, 23186163, 24275569
S183 O-Glycosylation GlyGen 23301498, 35138101, 30620550, ...31492838, 35289036, 29249144, 22661428, 29237092, 34725712, 31373491, 32119511, 30397120, 32574038, 35132862, 20305658, 29351928, 28657654, 27655845, 34846842, 33214551, 30379171, 30059200, 21740066, 35254053, 34019948, 36240223
S183 Phosphorylation PhosphoSitePlus
S185 Phosphorylation PhosphoSitePlus
S189 Phosphorylation PhosphoSitePlus
S198 Phosphorylation PhosphoSitePlus
S231 Phosphorylation PhosphoSitePlus
S306 Phosphorylation PhosphoSitePlus
T308 Phosphorylation PhosphoSitePlus
T373 Phosphorylation PhosphoSitePlus
K375 Ubiquitination PhosphoSitePlus
S378 Phosphorylation IEDB   neXtProt   phospho.ELM   PhosphoSitePlus   UniProt 17081983, 33936100, 31656913, ...12374799, 32387766, 29493099, 27869121
S378 Phosphorylation Q9H4A3 (WNK1) neXtProt   UniProt 31656913, 12374799
S382 Phosphorylation neXtProt   PhosphoSitePlus   RLIMS-P   Signor   UniProt 16832045, 34289367, 17190791, ...31656913, 15883153, 22032326, 29176664, 16263722, 18270262, 12374799
S382 Phosphorylation Q9BYP7 (WNK3) neXtProt   PhosphoSitePlus   Signor 22032326
S382 Phosphorylation Q9H4A3 (WNK1) neXtProt   PhosphoSitePlus   Signor   UniProt 15883153, 18270262, 22032326, ...12374799, 17190791
S382 Phosphorylation Q9Y3S1 (WNK2) neXtProt   PhosphoSitePlus   Signor 22032326
T436 O-Glycosylation GlyGen 30379171
S437 O-Glycosylation GlyGen 30379171
S599 Phosphorylation PhosphoSitePlus
S679 Phosphorylation PhosphoSitePlus
T1098 Phosphorylation PhosphoSitePlus
Y1102 Phosphorylation PhosphoSitePlus
K1104 Acetylation PhosphoSitePlus
S1105 Phosphorylation PhosphoSitePlus
S1108 Phosphorylation PhosphoSitePlus
S1110 Phosphorylation PhosphoSitePlus
T1115 Phosphorylation PhosphoSitePlus
S1116 Phosphorylation PhosphoSitePlus
K1119 Acetylation PhosphoSitePlus
K1128 Acetylation PhosphoSitePlus
Y1215 Phosphorylation PhosphoSitePlus
S1220 Phosphorylation PhosphoSitePlus
S1234 O-Glycosylation GlyGen 23301498, 35138101, 30620550, ...31492838, 35289036, 29249144, 22661428, 29237092, 34725712, 31373491, 32119511, 30397120, 32574038, 35132862, 20305658, 29351928, 28657654, 27655845, 34846842, 33214551, 30379171, 30059200, 21740066, 35254053, 34019948, 36240223
S1235 O-Glycosylation GlyGen 23301498, 35138101, 30620550, ...31492838, 35289036, 29249144, 22661428, 29237092, 34725712, 31373491, 32119511, 30397120, 32574038, 32938750, 35132862, 20305658, 29351928, 28657654, 27655845, 34846842, 33214551, 30379171, 30059200, 21740066, 35254053, 34019948, 36240223
T1244 O-Glycosylation GlyGen 23301498, 35138101, 30620550, ...31492838, 35289036, 29249144, 22661428, 29237092, 34725712, 31373491, 32119511, 30397120, 32574038, 35132862, 20305658, 29351928, 28657654, 27655845, 34846842, 33214551, 30379171, 30059200, 21740066, 35254053, 34019948, 36240223
S1245 O-Glycosylation GlyGen 23301498, 35138101, 30620550, ...31492838, 35289036, 29249144, 22661428, 29237092, 34725712, 31373491, 32119511, 30397120, 32574038, 32938750, 35132862, 20305658, 29351928, 28657654, 27655845, 34846842, 33214551, 30379171, 30059200, 21740066, 35254053, 34019948, 36240223
S1246 O-Glycosylation GlyGen 23301498, 35138101, 30620550, ...31492838, 35289036, 29249144, 22661428, 29237092, 34725712, 31373491, 32119511, 30397120, 32574038, 35132862, 20305658, 29351928, 28657654, 27655845, 34846842, 33214551, 30379171, 30059200, 21740066, 35254053, 34019948, 36240223
T1248 O-Glycosylation GlyGen 23301498, 35138101, 30620550, ...31492838, 35289036, 29249144, 22661428, 29237092, 34725712, 31373491, 32119511, 30397120, 32574038, 35132862, 20305658, 29351928, 28657654, 27655845, 34846842, 33214551, 30379171, 30059200, 21740066, 35254053, 34019948, 36240223
S1253 O-Glycosylation GlyGen 23301498, 35138101, 30620550, ...31492838, 35289036, 29249144, 22661428, 29237092, 34725712, 31373491, 32119511, 30397120, 32574038, 35132862, 20305658, 29351928, 28657654, 27655845, 34846842, 33214551, 30379171, 30059200, 21740066, 35254053, 34019948, 36240223
S1253 Phosphorylation PhosphoSitePlus
S1261 O-Glycosylation GlyGen 23301498, 35138101, 30620550, ...31492838, 35289036, 29249144, 22661428, 29237092, 34725712, 31373491, 32119511, 30397120, 32574038, 35132862, 20305658, 29351928, 28657654, 27655845, 34846842, 33214551, 30379171, 30059200, 21740066, 35254053, 34019948, 36240223
S1261 Phosphorylation phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 23186163, 16964243, 17190791, ...18669648, 20068231, 22032326
S1276 O-Glycosylation GlyGen 23301498, 35138101, 30620550, ...31492838, 35289036, 29249144, 22661428, 29237092, 34725712, 31373491, 32119511, 30397120, 32574038, 35132862, 20305658, 29351928, 28657654, 27655845, 34846842, 33214551, 30379171, 30059200, 21740066, 35254053, 34019948, 36240223
T1279 O-Glycosylation GlyGen 23301498, 35138101, 30620550, ...31492838, 35289036, 29249144, 22661428, 29237092, 34725712, 31373491, 32119511, 30397120, 32574038, 35132862, 20305658, 29351928, 28657654, 27655845, 34846842, 33214551, 30379171, 30059200, 21740066, 35254053, 34019948, 36240223
T1281 O-Glycosylation GlyGen 23301498, 35138101, 30620550, ...31492838, 35289036, 29249144, 22661428, 29237092, 34725712, 31373491, 32119511, 30397120, 32574038, 35132862, 20305658, 29351928, 28657654, 27655845, 34846842, 33214551, 30379171, 30059200, 21740066, 35254053, 34019948, 36240223
S1285 O-Glycosylation GlyGen 23301498, 35138101, 30620550, ...31492838, 35289036, 29249144, 22661428, 29237092, 34725712, 31373491, 32119511, 30397120, 32574038, 35132862, 20305658, 29351928, 28657654, 27655845, 34846842, 33214551, 30379171, 30059200, 21740066, 35254053, 34019948, 36240223
S1285 Phosphorylation PhosphoSitePlus
S1289 O-Glycosylation GlyGen 23301498, 35138101, 30620550, ...31492838, 35289036, 29249144, 22661428, 29237092, 34725712, 31373491, 32119511, 30397120, 32574038, 35132862, 20305658, 29351928, 28657654, 27655845, 34846842, 33214551, 30379171, 30059200, 21740066, 35254053, 34019948, 36240223
S1295 Phosphorylation PhosphoSitePlus
S1297 Phosphorylation phospho.ELM   PhosphoSitePlus 18220336
S1299 O-Glycosylation GlyGen 23301498, 35138101, 30620550, ...31492838, 35289036, 29249144, 22661428, 29237092, 34725712, 31373491, 32119511, 30397120, 32574038, 35132862, 20305658, 29351928, 28657654, 27655845, 34846842, 33214551, 30379171, 30059200, 21740066, 35254053, 34019948, 36240223
S1300 Phosphorylation phospho.ELM   PhosphoSitePlus 18220336
T1521 O-Glycosylation GlyGen 23301498, 35138101, 30620550, ...31492838, 35289036, 29249144, 22661428, 29237092, 34725712, 31373491, 32119511, 30397120, 32574038, 35132862, 20305658, 29351928, 28657654, 27655845, 34846842, 33214551, 30379171, 30059200, 21740066, 35254053, 34019948, 36240223
S1543 O-Glycosylation GlyGen 23301498, 35138101, 30620550, ...31492838, 35289036, 29249144, 22661428, 29237092, 34725712, 31373491, 32119511, 30397120, 32574038, 35132862, 20305658, 29351928, 28657654, 27655845, 34846842, 33214551, 30379171, 30059200, 21740066, 35254053, 34019948, 36240223
S1558 O-Glycosylation GlyGen 23301498, 35138101, 30620550, ...31492838, 35289036, 29249144, 22661428, 29237092, 34725712, 31373491, 32119511, 30397120, 32574038, 35132862, 20305658, 29351928, 28657654, 27655845, 34846842, 33214551, 30379171, 30059200, 21740066, 35254053, 34019948, 36240223
S1559 O-Glycosylation GlyGen 23301498, 35138101, 30620550, ...31492838, 35289036, 29249144, 22661428, 29237092, 34725712, 31373491, 32119511, 30397120, 32574038, 35132862, 20305658, 29351928, 28657654, 27655845, 34846842, 33214551, 30379171, 30059200, 21740066, 35254053, 34019948, 36240223
S1562 O-Glycosylation GlyGen 23301498, 35138101, 30620550, ...31492838, 35289036, 29249144, 22661428, 29237092, 34725712, 31373491, 32119511, 30397120, 32574038, 35132862, 20305658, 29351928, 28657654, 27655845, 34846842, 33214551, 30379171, 30059200, 21740066, 35254053, 34019948, 36240223
K1653 Ubiquitination PhosphoSitePlus
K1658 Ubiquitination PhosphoSitePlus
S1681 O-Glycosylation GlyGen 23301498, 35138101, 30620550, ...31492838, 35289036, 29249144, 22661428, 29237092, 34725712, 31373491, 32119511, 30397120, 32574038, 35132862, 20305658, 29351928, 28657654, 27655845, 34846842, 33214551, 30379171, 30059200, 21740066, 35254053, 34019948, 36240223
T1687 O-Glycosylation GlyGen 23301498, 35138101, 30620550, ...31492838, 35289036, 29249144, 22661428, 29237092, 34725712, 31373491, 32119511, 30397120, 32574038, 35132862, 20305658, 29351928, 28657654, 27655845, 34846842, 33214551, 30379171, 30059200, 21740066, 35254053, 34019948, 36240223
T1695 O-Glycosylation GlyGen 23301498, 35138101, 30620550, ...31492838, 35289036, 29249144, 22661428, 29237092, 34725712, 31373491, 32119511, 30397120, 32574038, 35132862, 20305658, 29351928, 28657654, 27655845, 34846842, 33214551, 30379171, 30059200, 21740066, 35254053, 34019948, 36240223
T1757 O-Glycosylation GlyGen 23301498, 35138101, 30620550, ...31492838, 35289036, 29249144, 22661428, 29237092, 34725712, 31373491, 32119511, 30397120, 32574038, 35132862, 20305658, 29351928, 28657654, 27655845, 34846842, 33214551, 30379171, 30059200, 21740066, 35254053, 34019948, 36240223
T1810 Phosphorylation PhosphoSitePlus
T1812 O-Glycosylation GlyGen 23301498, 35138101, 30620550, ...31492838, 35289036, 29249144, 22661428, 29237092, 34725712, 31373491, 32119511, 30397120, 32574038, 35132862, 20305658, 29351928, 28657654, 27655845, 34846842, 33214551, 30379171, 30059200, 21740066, 35254053, 34019948, 36240223
S1813 O-Glycosylation GlyGen 23301498, 35138101, 30620550, ...31492838, 35289036, 29249144, 22661428, 29237092, 34725712, 31373491, 32119511, 30397120, 32574038, 35132862, 20305658, 29351928, 28657654, 27655845, 34846842, 33214551, 30379171, 30059200, 21740066, 35254053, 34019948, 36240223
T1827 O-Glycosylation GlyGen 23301498, 35138101, 30620550, ...31492838, 35289036, 29249144, 22661428, 29237092, 34725712, 31373491, 32119511, 30397120, 32574038, 35132862, 20305658, 29351928, 28657654, 27655845, 34846842, 33214551, 30379171, 30059200, 21740066, 35254053, 34019948, 36240223
S1838 Phosphorylation PhosphoSitePlus
T1848 O-Glycosylation GlyGen 23301498, 35138101, 30620550, ...31492838, 35289036, 29249144, 22661428, 29237092, 34725712, 31373491, 32119511, 30397120, 32574038, 32938750, 35132862, 20305658, 29351928, 28657654, 27655845, 34846842, 33214551, 30379171, 30059200, 21740066, 35254053, 34019948, 36240223
T1848 Phosphorylation PhosphoSitePlus   UniProt 17190791
S1849 O-Glycosylation GlyGen 23301498, 35138101, 30620550, ...31492838, 35289036, 29249144, 22661428, 29237092, 34725712, 31373491, 32119511, 30397120, 32574038, 32938750, 35132862, 20305658, 29351928, 28657654, 27655845, 34846842, 33214551, 30379171, 30059200, 21740066, 35254053, 34019948, 36240223
S1849 Phosphorylation PhosphoSitePlus
S1850 O-Glycosylation GlyGen 23301498, 35138101, 30620550, ...31492838, 35289036, 29249144, 22661428, 29237092, 34725712, 31373491, 32119511, 30397120, 32574038, 35132862, 20305658, 29351928, 28657654, 27655845, 34846842, 33214551, 30379171, 30059200, 21740066, 35254053, 34019948, 36240223
S1863 O-Glycosylation GlyGen 23301498, 35138101, 30620550, ...31492838, 35289036, 29249144, 22661428, 29237092, 34725712, 31373491, 32119511, 30397120, 32574038, 32938750, 35132862, 20305658, 29351928, 28657654, 27655845, 34846842, 33214551, 30379171, 30059200, 21740066, 35254053, 34019948, 36240223
S1887 Phosphorylation PhosphoSitePlus
T1929 O-Glycosylation GlyGen 23301498, 35138101, 30620550, ...31492838, 35289036, 29249144, 22661428, 29237092, 34725712, 31373491, 32119511, 30397120, 32574038, 35132862, 20305658, 29351928, 28657654, 27655845, 34846842, 33214551, 30379171, 30059200, 21740066, 35254053, 34019948, 36240223
S1931 O-Glycosylation GlyGen 23301498, 35138101, 30620550, ...31492838, 35289036, 29249144, 22661428, 29237092, 34725712, 31373491, 32119511, 30397120, 32574038, 35132862, 20305658, 29351928, 28657654, 27655845, 34846842, 33214551, 30379171, 30059200, 21740066, 35254053, 34019948, 36240223
S1935 O-Glycosylation GlyGen 23301498, 35138101, 30620550, ...31492838, 35289036, 29249144, 22661428, 29237092, 34725712, 31373491, 32119511, 30397120, 32574038, 35132862, 20305658, 29351928, 28657654, 27655845, 34846842, 33214551, 30379171, 30059200, 21740066, 35254053, 34019948, 36240223
S1935 Phosphorylation PhosphoSitePlus
T1937 Phosphorylation PhosphoSitePlus
T1941 Phosphorylation PhosphoSitePlus
T1949 O-Glycosylation GlyGen 23301498, 35138101, 30620550, ...31492838, 35289036, 29249144, 22661428, 29237092, 34725712, 31373491, 32119511, 30397120, 32574038, 35132862, 20305658, 29351928, 28657654, 27655845, 34846842, 33214551, 30379171, 30059200, 21740066, 35254053, 34019948, 36240223
T1950 O-Glycosylation GlyGen 23301498, 35138101, 30620550, ...31492838, 35289036, 29249144, 22661428, 29237092, 34725712, 31373491, 32119511, 30397120, 32574038, 35132862, 20305658, 29351928, 28657654, 27655845, 34846842, 33214551, 30379171, 30059200, 21740066, 35254053, 34019948, 36240223
T1951 O-Glycosylation GlyGen 23301498, 35138101, 30620550, ...31492838, 35289036, 29249144, 22661428, 29237092, 34725712, 31373491, 32119511, 30397120, 32574038, 35132862, 20305658, 29351928, 28657654, 27655845, 34846842, 33214551, 30379171, 30059200, 21740066, 35254053, 34019948, 36240223
S1959 Phosphorylation PhosphoSitePlus
S1961 Phosphorylation PhosphoSitePlus
T1963 Phosphorylation PhosphoSitePlus
T1968 Phosphorylation PhosphoSitePlus
T1970 Phosphorylation PhosphoSitePlus
S1978 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 20068231, 18669648, 19690332, ...24275569
S2002 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 17081983
S2005 Phosphorylation PhosphoSitePlus
S2011 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 17081983
S2012 Phosphorylation phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 18669648, 17081983, 17190791
S2027 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 21406692, 24275569
S2029 Phosphorylation phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 18669648, 23186163, 21406692, ...17190791
S2032 Phosphorylation phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 21406692, 23186163, 17081983, ...17190791, 18669648, 21659604, 20068231
S2032 Phosphorylation P42345 (MTOR) PhosphoSitePlus 21659604
S2037 Phosphorylation PhosphoSitePlus
S2038 Phosphorylation PhosphoSitePlus
S2065 Phosphorylation PhosphoSitePlus
Y2102 Phosphorylation PhosphoSitePlus
S2121 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 20068231
T2128 Phosphorylation PhosphoSitePlus
S2145 Phosphorylation PhosphoSitePlus
K2243 Ubiquitination PhosphoSitePlus
T2245 Phosphorylation PhosphoSitePlus
T2247 Phosphorylation PhosphoSitePlus
S2265 Phosphorylation PhosphoSitePlus
S2270 Phosphorylation PhosphoSitePlus
Y2276 Phosphorylation PhosphoSitePlus
S2286 Phosphorylation PhosphoSitePlus
S2294 Phosphorylation PhosphoSitePlus
S2302 O-Glycosylation GlyGen 23301498, 35138101, 30620550, ...31492838, 35289036, 29249144, 22661428, 29237092, 34725712, 31373491, 32119511, 30397120, 32574038, 35132862, 20305658, 29351928, 28657654, 27655845, 34846842, 33214551, 30379171, 30059200, 21740066, 35254053, 34019948, 36240223
S2306 O-Glycosylation GlyGen 23301498, 35138101, 30620550, ...31492838, 35289036, 29249144, 22661428, 29237092, 34725712, 31373491, 32119511, 30397120, 32574038, 35132862, 20305658, 29351928, 28657654, 27655845, 34846842, 33214551, 30379171, 30059200, 21740066, 35254053, 34019948, 36240223
S2358 O-Glycosylation GlyGen 23301498, 35138101, 30620550, ...31492838, 35289036, 29249144, 22661428, 29237092, 34725712, 31373491, 32119511, 30397120, 32574038, 35132862, 20305658, 29351928, 28657654, 27655845, 34846842, 33214551, 30379171, 30059200, 21740066, 35254053, 34019948, 36240223
S2370 O-Glycosylation GlyGen 23301498, 35138101, 30620550, ...31492838, 35289036, 29249144, 22661428, 29237092, 34725712, 31373491, 32119511, 30397120, 32574038, 35132862, 20305658, 29351928, 28657654, 27655845, 34846842, 33214551, 30379171, 30059200, 21740066, 35254053, 34019948, 36240223
S2370 Phosphorylation PhosphoSitePlus   UniProt 23186163
S2372 O-Glycosylation GlyGen 23301498, 35138101, 30620550, ...31492838, 35289036, 29249144, 22661428, 29237092, 34725712, 31373491, 32119511, 30397120, 32574038, 35132862, 20305658, 29351928, 28657654, 27655845, 34846842, 33214551, 30379171, 30059200, 21740066, 35254053, 34019948, 36240223
S2372 Phosphorylation PhosphoSitePlus   RLIMS-P   UniProt 23186163, 17190791
S2377 O-Glycosylation GlyGen 23301498, 35138101, 30620550, ...31492838, 35289036, 29249144, 22661428, 29237092, 34725712, 31373491, 32119511, 30397120, 32574038, 35132862, 20305658, 29351928, 28657654, 27655845, 34846842, 33214551, 30379171, 30059200, 21740066, 35254053, 34019948, 36240223
R2380 Methylation PhosphoSitePlus
T2381 O-Glycosylation GlyGen 23301498, 35138101, 30620550, ...31492838, 35289036, 29249144, 22661428, 29237092, 34725712, 31373491, 32119511, 30397120, 32574038, 35132862, 20305658, 29351928, 28657654, 27655845, 34846842, 33214551, 30379171, 30059200, 21740066, 35254053, 34019948, 36240223
T2382 O-Glycosylation GlyGen 23301498, 35138101, 30620550, ...31492838, 35289036, 29249144, 22661428, 29237092, 34725712, 31373491, 32119511, 30397120, 32574038, 35132862, 20305658, 29351928, 28657654, 27655845, 34846842, 33214551, 30379171, 30059200, 21740066, 35254053, 34019948, 36240223
Site PTM Type PTM Enzyme Score Source PMID
K25 Sumoylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S780 Phosphorylation PhosphoSitePlus
S847 Phosphorylation PhosphoSitePlus
S1009 Phosphorylation PhosphoSitePlus
S1015 Phosphorylation PhosphoSitePlus
S1035 Phosphorylation PhosphoSitePlus
S2071 Phosphorylation PhosphoSitePlus


Q9H4A3 (WNK1) as PTM Enzyme



Substrate Site Score Source PMID
O95747 (OXSR1) T185 neXtProt   phospho.ELM   PhosphoSitePlus   Signor 24191005, 16083423, 17190791
O95747 (OXSR1) S325 phospho.ELM   PhosphoSitePlus   Signor 24191005, 16083423, 17190791
Q15796 (SMAD2) S110 neXtProt 17392271
Q15796 (SMAD2) S260 neXtProt 17392271
Q15796 (SMAD2) S465 neXtProt 17392271
Q8N9I0 (SYT2) T199 neXtProt   Signor 15350218
Q8N9I0 (SYT2) T383 neXtProt 15350218
Q9H4A3 (WNK1) S378 neXtProt   UniProt 31656913, 12374799
Q9H4A3 (WNK1) S382 neXtProt   PhosphoSitePlus   Signor   UniProt 15883153, 18270262, 22032326, ...12374799, 17190791
Q9UEW8 (STK39) T231 neXtProt   PhosphoSitePlus   Signor 17190791, 16083423, 16263722
Q9UEW8 (STK39) S371 neXtProt   PhosphoSitePlus   Signor 17190791, 18270262, 16083423, ...16263722
Q9UHW9 (SLC12A6) T991 neXtProt   PhosphoSitePlus   Signor 19665974
Q9UHW9 (SLC12A6) T1048 neXtProt   PhosphoSitePlus   Signor 19665974


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
T12 A12 Biomuta DOID:10534 / stomach cancer [ cosmic ]
T60 I60 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]
R66 L66 Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
T74 A74 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
S167 F167 Biomuta DOID:4159 / skin cancer [ cosmic ]
S437 R437 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]
S780 C780 Biomuta DOID:1612 / breast cancer [ cosmic ]
S847 N847 Biomuta DOID:4159 / skin cancer [ cosmic ]
S1035 Y1035 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
T1098 I1098 Biomuta DOID:10534 / stomach cancer [ cosmic ]
S1110 C1110 Biomuta DOID:5041 / esophageal cancer [ cosmic ]
S1235 F1235 Biomuta DOID:4159 / skin cancer [ cosmic ]
S1246 Y1246 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S1253 F1253 Biomuta DOID:4159 / skin cancer [ cosmic ] DOID:1324 / lung cancer [ cosmic, icgc ]
S1289 N1289 Biomuta DOID:4362 / cervical cancer [ icgc ]
S1297 C1297 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S1299 L1299 Biomuta DOID:4159 / skin cancer [ cosmic ]
S1300 C1300 Biomuta DOID:263 / kidney cancer [ cosmic, icgc ]
S1300 P1300 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S1558 C1558 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ]
S1562 F1562 Biomuta DOID:363 / uterine cancer [ icgc ]
S1562 Y1562 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
K1653 M1653 Biomuta DOID:3571 / liver cancer [ cosmic ]
S1849 N1849 Biomuta [ cosmic ]
T1970 P1970 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
S2002 A2002 Biomuta DOID:10534 / stomach cancer [ cosmic ]
S2005 L2005 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S2145 N2145 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S2265 L2265 Biomuta DOID:4362 / cervical cancer [ cosmic, icgc ]
S2306 F2306 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]
S2370 F2370 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S2377 T2377 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
R2380 Q2380 Biomuta DOID:10534 / stomach cancer [ cosmic ]
T2382 P2382 Biomuta DOID:263 / kidney cancer [ cosmic ]