iPTMnet Report for Q9H3S7 (PTPN23)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9H3S7 / PTN23_HUMAN
Protein Name Tyrosine-protein phosphatase non-receptor type 23
Gene Name Name: PTPN23
Synonyms:KIAA1471;
Organism Homo sapiens (Human)

PRO ID PR:Q9H3S7
DAG View
PRO Name tyrosine-protein phosphatase non-receptor type 23 (human)
Definition A tyrosine-protein phosphatase non-receptor type 23 that is encoded in the genome of human.
Short Label hPTPN23
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9H3S7 (PTPN23) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K28 Ubiquitination PhosphoSitePlus
K32 Ubiquitination PhosphoSitePlus
K46 Ubiquitination PhosphoSitePlus
S66 Phosphorylation PhosphoSitePlus
K70 Ubiquitination PhosphoSitePlus
Y213 Phosphorylation PhosphoSitePlus
K215 Ubiquitination PhosphoSitePlus
K279 Ubiquitination PhosphoSitePlus
K285 Ubiquitination PhosphoSitePlus
K288 Ubiquitination PhosphoSitePlus
T293 Phosphorylation PhosphoSitePlus
K314 Ubiquitination PhosphoSitePlus
K340 Ubiquitination PhosphoSitePlus
K359 Ubiquitination PhosphoSitePlus
S370 Phosphorylation PhosphoSitePlus
K472 Ubiquitination PhosphoSitePlus
S484 Phosphorylation PhosphoSitePlus
K500 Ubiquitination PhosphoSitePlus
S509 Phosphorylation PhosphoSitePlus
T511 Phosphorylation PhosphoSitePlus
S513 Phosphorylation PhosphoSitePlus
K550 Ubiquitination PhosphoSitePlus
K557 Ubiquitination PhosphoSitePlus
T587 Phosphorylation HPRD 20068231
S589 Phosphorylation PhosphoSitePlus
K600 Ubiquitination PhosphoSitePlus
K608 Methylation PhosphoSitePlus
K613 Methylation PhosphoSitePlus
S645 Phosphorylation PhosphoSitePlus
Y679 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18669648
T693 Phosphorylation PhosphoSitePlus
T696 Phosphorylation PhosphoSitePlus
R730 Methylation PhosphoSitePlus
S733 Phosphorylation PhosphoSitePlus   UniProt 23186163
S747 Phosphorylation PhosphoSitePlus
R950 Methylation PhosphoSitePlus   UniProt 24129315
S1121 Phosphorylation HPRD   PhosphoSitePlus 17081983
S1122 O-Glycosylation GlyGen 23301498, 27655845, 33214551, ...35138101, 32870666, 34725712, 30059200, 29351928, 34019948, 31492838, 32119511, 35289036, 29237092
S1122 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 18669648, 20068231, 24275569
S1123 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 18669648, 19690332, 20068231
S1126 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 17525332, 18669648, 20068231
T1131 O-Glycosylation GlyGen 23301498, 27655845, 33214551, ...35138101, 32870666, 34725712, 30059200, 29351928, 34019948, 31492838, 32119511, 35289036, 29237092
T1131 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 18669648, 24275569
S1133 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18669648, 20068231
Y1165 Phosphorylation PhosphoSitePlus
S1210 Phosphorylation PhosphoSitePlus
S1218 Phosphorylation PhosphoSitePlus
K1220 Ubiquitination PhosphoSitePlus
Y1229 Phosphorylation PhosphoSitePlus
S1290 Phosphorylation PhosphoSitePlus
S1335 Phosphorylation PhosphoSitePlus
C1466 S-Nitrosylation dbSNO 22178444
S1473 O-Glycosylation GlyGen 23301498, 27655845, 33214551, ...35138101, 32870666, 34725712, 30059200, 29351928, 34019948, 31492838, 32119511, 35289036, 29237092
S1475 Phosphorylation PhosphoSitePlus
S1484 Phosphorylation PhosphoSitePlus
S1496 O-Glycosylation GlyGen 23301498, 27655845, 33214551, ...35138101, 32870666, 34725712, 30059200, 29351928, 34019948, 31492838, 32119511, 35289036, 29237092
S1542 Phosphorylation PhosphoSitePlus
S1549 Phosphorylation PhosphoSitePlus
S1589 Phosphorylation PhosphoSitePlus
S1593 Phosphorylation PhosphoSitePlus
R1595 Methylation PhosphoSitePlus
S1601 Phosphorylation PhosphoSitePlus
R1615 Methylation PhosphoSitePlus   UniProt 24129315
T1617 O-Glycosylation GlyGen 32938750
R1618 Methylation PhosphoSitePlus
S1620 Phosphorylation PhosphoSitePlus
S1625 Phosphorylation PhosphoSitePlus
T1632 Phosphorylation PhosphoSitePlus
K1635 Ubiquitination PhosphoSitePlus
T1636 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K32 N32 Biomuta DOID:1324 / lung cancer [ cosmic ]
Y213 C213 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
Y213 H213 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K215 N215 Biomuta DOID:4362 / cervical cancer [ cosmic ]
S484 P484 Biomuta DOID:10534 / stomach cancer [ cosmic ]
T693 M693 Biomuta DOID:5041 / esophageal cancer [ cosmic ]
S1123 I1123 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
S1133 F1133 Biomuta DOID:1793 / pancreatic cancer [ cosmic, icgc ]
S1133 P1133 Biomuta DOID:10534 / stomach cancer [ cosmic ]
C1466 W1466 Biomuta DOID:10283 / prostate cancer [ cosmic, icgc ]
C1466 G1466 Biomuta DOID:10534 / stomach cancer [ cosmic ]
S1473 N1473 Biomuta DOID:10534 / stomach cancer [ cosmic ]
S1542 F1542 Biomuta DOID:363 / uterine cancer [ icgc ]
R1595 W1595 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
R1615 Q1615 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:1781 / thyroid gland cancer [ cosmic ]
R1618 Q1618 Biomuta DOID:10534 / stomach cancer [ cosmic ]
S1620 T1620 Biomuta DOID:10534 / stomach cancer [ cosmic ]