iPTMnet Report for Q9H3N1 (TMX1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9H3N1 / TMX1_HUMAN
Protein Name Thioredoxin-related transmembrane protein 1 precursor
Gene Name Name: TMX1
Synonyms:TMX,TXNDC,TXNDC1;ORFNames:PSEC0085,UNQ235/PRO268;
Organism Homo sapiens (Human)

PRO ID PR:Q9H3N1
DAG View
PRO Name thioredoxin-related transmembrane protein 1 (human)
Definition A thioredoxin-related transmembrane protein 1 that is encoded in the genome of human.
Short Label hTMX1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9H3N1 (TMX1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K107 Ubiquitination PhosphoSitePlus
K121 Ubiquitination PhosphoSitePlus
K130 Ubiquitination PhosphoSitePlus
Y219 Phosphorylation PhosphoSitePlus
S221 Phosphorylation PhosphoSitePlus
K223 Ubiquitination PhosphoSitePlus
S226 Phosphorylation PhosphoSitePlus
S228 Phosphorylation PhosphoSitePlus   UniProt 23186163
K233 Ubiquitination PhosphoSitePlus
S247 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 19413330, 19369195, 21406692, ...18491316, 18088087, 17081983, 20230923, 15302935, 20058876, 18318008, 19651622, 18669648, 20166139, 23186163, 18452278, 19690332, 20068231
S253 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18669648, 18452278
T257 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18669648
K259 Ubiquitination PhosphoSitePlus
S270 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 21406692, 23186163, 18767875, ...20058876, 18578522, 19651622, 18669648, 20166139, 19690332, 20068231
S274 Phosphorylation HPRD   PhosphoSitePlus   UniProt 19651622, 23186163
T277 Phosphorylation HPRD   PhosphoSitePlus 20068231
K279 Ubiquitination PhosphoSitePlus
S280 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 18691976, 23186163, 19651622, ...18669648, 20068231


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K223 Q223 Biomuta DOID:363 / uterine cancer [ icgc ]
S226 L226 Biomuta DOID:1612 / breast cancer [ icgc ]
T257 P257 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S280 F280 Biomuta DOID:4159 / skin cancer [ cosmic ]