iPTMnet Report for Q9H2K2 (TNKS2)
Protein Information
UniProt AC / UniProt ID | Q9H2K2 / TNKS2_HUMAN |
Protein Name | Poly [ADP-ribose] polymerase tankyrase-2 |
Gene Name | Name: TNKS2 Synonyms:PARP5B; |
Organism | Homo sapiens (Human) |
PRO ID | PR:Q9H2K2 |
PRO Name | poly [ADP-ribose] polymerase tankyrase-2 (human) |
Definition | A poly [ADP-ribose] polymerase tankyrase-2 that is encoded in the genome of human. |
Short Label | hTNKS2 |
Category | organism-gene |
Q9H2K2 (TNKS2) as Substrate
Site | PTM Type | PTM Enzyme | Score | Source | PMID | |
---|---|---|---|---|---|---|
T45 | Phosphorylation | score1 | PhosphoSitePlus | |||
K48 | Ubiquitination | score1 | PhosphoSitePlus | |||
K71 | Ubiquitination | score1 | PhosphoSitePlus | |||
K169 | Ubiquitination | score1 | PhosphoSitePlus | |||
K177 | Acetylation | score1 | PhosphoSitePlus | |||
K177 | Ubiquitination | score1 | PhosphoSitePlus | |||
K178 | Ubiquitination | score1 | PhosphoSitePlus | |||
K192 | Ubiquitination | score1 | PhosphoSitePlus | |||
K211 | Ubiquitination | score1 | PhosphoSitePlus | |||
K225 | Ubiquitination | score1 | PhosphoSitePlus | |||
H238 | Dihydroxylation | score2 | IntAct | 21251231 | ||
K242 | Ubiquitination | score1 | PhosphoSitePlus | |||
C293 | Methylation | score1 | IEDB | 31844290 | ||
K323 | Ubiquitination | score1 | PhosphoSitePlus | |||
K331 | Ubiquitination | score1 | PhosphoSitePlus | |||
K359 | Ubiquitination | score1 | PhosphoSitePlus | |||
S374 | Phosphorylation | score1 | PhosphoSitePlus | |||
K378 | Ubiquitination | score1 | PhosphoSitePlus | |||
K380 | Ubiquitination | score1 | PhosphoSitePlus | |||
K398 | Ubiquitination | score1 | PhosphoSitePlus | |||
K410 | Ubiquitination | score1 | PhosphoSitePlus | |||
K421 | Ubiquitination | score1 | PhosphoSitePlus | |||
K425 | Ubiquitination | score1 | PhosphoSitePlus | |||
K501 | Ubiquitination | score1 | PhosphoSitePlus | |||
K510 | Ubiquitination | score1 | PhosphoSitePlus | |||
H553 | Dihydroxylation | score2 | IntAct | 21251231 | ||
K555 | Ubiquitination | score1 | PhosphoSitePlus | |||
K557 | Ubiquitination | score1 | PhosphoSitePlus | |||
K592 | Ubiquitination | score1 | PhosphoSitePlus | |||
K602 | Ubiquitination | score1 | PhosphoSitePlus | |||
K604 | Ubiquitination | score1 | PhosphoSitePlus | |||
K609 | Ubiquitination | score1 | PhosphoSitePlus | |||
T619 | Phosphorylation | score1 | PhosphoSitePlus | |||
K620 | Ubiquitination | score1 | PhosphoSitePlus | |||
K633 | Ubiquitination | score1 | PhosphoSitePlus | |||
K654 | Ubiquitination | score1 | PhosphoSitePlus | |||
K663 | Ubiquitination | score1 | PhosphoSitePlus | |||
S666 | Phosphorylation | score1 | PhosphoSitePlus | |||
K743 | Ubiquitination | score1 | PhosphoSitePlus | |||
K869 | Ubiquitination | score1 | PhosphoSitePlus | |||
K928 | Ubiquitination | score1 | PhosphoSitePlus | |||
K996 | Ubiquitination | score1 | PhosphoSitePlus | |||
T1010 | Phosphorylation | score1 | PhosphoSitePlus | |||
S1017 | Phosphorylation | score2 | HPRD PhosphoSitePlus | 19651622 |
PTM sites affected in variants
Site | Variant | Source | PMID | Disease [Sample source] |
---|---|---|---|---|
T45 | M45 | Biomuta | DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ] | |
K177 | E177 | Biomuta | DOID:363 / uterine cancer [ cosmic, icgc ] | |
K398 | * | Biomuta | DOID:1324 / lung cancer [ cosmic ] | |
T619 | K619 | Biomuta | DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ] | |
K633 | Q633 | Biomuta | DOID:363 / uterine cancer [ cosmic, icgc ] | |
K654 | T654 | Biomuta | DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ] | |
K996 | N996 | Biomuta | DOID:363 / uterine cancer [ cosmic, icgc ] | |
T1010 | S1010 | Biomuta | DOID:1324 / lung cancer [ cosmic, icgc ] |