iPTMnet Report for Q9H2F5 (EPC1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9H2F5 / EPC1_HUMAN
Protein Name Enhancer of polycomb homolog 1
Gene Name Name: EPC1
Organism Homo sapiens (Human)

PRO ID PR:Q9H2F5
DAG View
PRO Name enhancer of polycomb homolog 1 (human)
Definition An enhancer of polycomb homolog 1 that is encoded in the genome of human.
Short Label hEPC1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9H2F5 (EPC1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S2 Phosphorylation PhosphoSitePlus
K3 Methylation PhosphoSitePlus
S5 Phosphorylation PhosphoSitePlus
S60 Phosphorylation PhosphoSitePlus
K68 Ubiquitination PhosphoSitePlus
S119 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
K148 Ubiquitination PhosphoSitePlus
S189 Phosphorylation PhosphoSitePlus
S193 Phosphorylation PhosphoSitePlus
K222 Acetylation PhosphoSitePlus
K233 Ubiquitination PhosphoSitePlus
S284 Phosphorylation PhosphoSitePlus
T352 Phosphorylation PhosphoSitePlus
S357 Phosphorylation phospho.ELM   PhosphoSitePlus 16964243
K512 Acetylation PhosphoSitePlus
K522 Ubiquitination PhosphoSitePlus
T533 Phosphorylation PhosphoSitePlus
S535 Phosphorylation PhosphoSitePlus
S539 Phosphorylation PhosphoSitePlus   UniProt 23186163
S625 Phosphorylation PhosphoSitePlus
S630 Phosphorylation PhosphoSitePlus
S723 O-Glycosylation GlyGen 30379171, 30059200, 29351928, ...35289036, 35254053, 28657654
S736 O-Glycosylation GlyGen 30379171, 30059200, 29351928, ...35289036, 35254053, 28657654
R756 Methylation PhosphoSitePlus
S762 O-Glycosylation GlyGen 30379171, 30059200, 29351928, ...35289036, 35254053, 28657654
T780 O-Glycosylation GlyGen 34846842, 30379171, 30059200, ...29351928, 35289036, 35254053, 28657654
S782 Phosphorylation PhosphoSitePlus
K801 Ubiquitination PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S119 Phosphorylation HPRD 18669648, 18452278
S357 Phosphorylation HPRD 19413330, 16964243


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S2 G2 Biomuta DOID:1793 / pancreatic cancer [ icgc ]
S5 L5 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S5 P5 Biomuta DOID:263 / kidney cancer [ cosmic, icgc ]
S60 L60 Biomuta DOID:4159 / skin cancer [ cosmic ]
K68 E68 Biomuta DOID:1324 / lung cancer [ cosmic ]
S189 C189 Biomuta [ cosmic ] DOID:1115 / sarcoma [ icgc ]
S284 C284 Biomuta DOID:2394 / ovarian cancer [ cosmic, icgc ]
S535 F535 Biomuta DOID:4159 / skin cancer [ cosmic ]
R756 P756 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
R756 Q756 Biomuta DOID:363 / uterine cancer [ icgc ] DOID:4362 / cervical cancer [ cosmic, icgc ] DOID:1324 / lung cancer [ cosmic, icgc ]
T780 N780 Biomuta DOID:363 / uterine cancer [ icgc ]