iPTMnet Report for Q9H211 (CDT1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9H211 / CDT1_HUMAN
Protein Name DNA replication factor Cdt1
Gene Name Name: CDT1
Organism Homo sapiens (Human)

PRO ID PR:Q9H211
DAG View
PRO Name DNA replication factor Cdt1 (human)
Definition A DNA replication factor Cdt1 that is encoded in the genome of human.
Short Label hCDT1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9H211 (CDT1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
T7 Phosphorylation PhosphoSitePlus
K24 Ubiquitination PhosphoSitePlus
T29 Phosphorylation P45983 (MAPK8) , P24941 (CDK2) HPRD   neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 30281379, 18669648, 15855168, ...21856198
S31 Phosphorylation P24941 (CDK2) HPRD   neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 30281379, 18669648, 15855168, ...23186163
S42 Phosphorylation PhosphoSitePlus
T44 Phosphorylation PhosphoSitePlus
S45 Phosphorylation PhosphoSitePlus
S73 Phosphorylation PhosphoSitePlus
T82 Phosphorylation PhosphoSitePlus
S93 Phosphorylation PhosphoSitePlus   UniProt 21856198
T102 Phosphorylation PhosphoSitePlus
T112 Phosphorylation PhosphoSitePlus
K141 Sumoylation PhosphoSitePlus
K141 Ubiquitination PhosphoSitePlus
S143 Phosphorylation PhosphoSitePlus
T152 Phosphorylation PhosphoSitePlus
K166 Ubiquitination PhosphoSitePlus
K218 Ubiquitination PhosphoSitePlus
K240 Ubiquitination PhosphoSitePlus
K259 Sumoylation PhosphoSitePlus
K259 Ubiquitination PhosphoSitePlus
K301 Ubiquitination PhosphoSitePlus
K307 Ubiquitination PhosphoSitePlus
K311 Ubiquitination PhosphoSitePlus
S318 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 15302935, 19690332, 21856198
K356 Ubiquitination PhosphoSitePlus
T358 Phosphorylation PhosphoSitePlus
S372 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18669648
K377 Sumoylation PhosphoSitePlus
K377 Ubiquitination PhosphoSitePlus
S380 Phosphorylation PhosphoSitePlus   UniProt 23186163
S390 Phosphorylation PhosphoSitePlus
S391 Phosphorylation PhosphoSitePlus
S394 Phosphorylation HPRD   IEDB   phospho.ELM   PhosphoSitePlus   UniProt 18669648, 33936100
R396 Methylation PhosphoSitePlus
T402 Phosphorylation PhosphoSitePlus
T406 Phosphorylation PhosphoSitePlus
S411 Phosphorylation PhosphoSitePlus
S413 Phosphorylation PhosphoSitePlus
K416 Ubiquitination PhosphoSitePlus
K429 Ubiquitination PhosphoSitePlus
K433 Sumoylation PhosphoSitePlus
K433 Ubiquitination PhosphoSitePlus
K470 Ubiquitination PhosphoSitePlus
S491 Phosphorylation PhosphoSitePlus
K522 Ubiquitination PhosphoSitePlus
K525 Ubiquitination PhosphoSitePlus
T533 Phosphorylation HPRD   PhosphoSitePlus 18767875
Site PTM Type PTM Enzyme Score Source PMID
K24 Acetylation PR:Q09472 (hEP300) , PR:Q92831 (hKAT2B) PRO 19276081
K49 Acetylation PR:Q92831 (hKAT2B) , PR:Q09472 (hEP300) PRO 19276081


Proteoforms

PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000028741 (hCDT1/iso:1/Ac:1) acK24,acK49 PR:Q92831 (hKAT2B) PRO 19276081
PR:000028741 (hCDT1/iso:1/Ac:1) acK24,acK49 PR:Q09472 (hEP300) PRO 19276081


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation O75496 (GMNN) T25 Q9H211 (CDT1) unknown eFIP 23695679
Phosphorylation Q9H211 (CDT1) T29 Q13309 (SKP2) unknown eFIP 17565698


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
T44 P44 Biomuta [ cosmic ]
T82 I82 Biomuta DOID:1612 / breast cancer [ cosmic ]
K166 T166 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
T402 I402 Biomuta DOID:4159 / skin cancer [ cosmic ]
T406 P406 Biomuta DOID:5041 / esophageal cancer [ cosmic ] DOID:1324 / lung cancer [ cosmic ] DOID:11054 / urinary bladder cancer [ cosmic, icgc ]