iPTMnet Report for Q9H1E3 (NUCKS1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9H1E3 / NUCKS_HUMAN
Protein Name Nuclear ubiquitous casein and cyclin-dependent kinase substrate 1
Gene Name Name: NUCKS1
Synonyms:NUCKS;ORFNames:JC7;
Organism Homo sapiens (Human)

PRO ID PR:Q9H1E3
DAG View
PRO Name nuclear ubiquitous casein and cyclin-dependent kinase substrate 1 (human)
Definition A nuclear ubiquitous casein and cyclin-dependent kinase substrate 1 that is encoded in the genome of human.
Short Label hNUCKS1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9H1E3 (NUCKS1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S2 Phosphorylation PhosphoSitePlus
K9 Acetylation PhosphoSitePlus
K9 Methylation PhosphoSitePlus
K9 Ubiquitination PhosphoSitePlus
Y13 Phosphorylation PhosphoSitePlus
S14 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 17525332, 23186163, 18669648
S19 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18691976, 17525332, 23186163, ...17081983, 18220336, 15302935, 21406692, 18318008, 19367720, 18669648, 24275569, 17693683, 17487921, 19690332, 20068231
Y26 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163
R28 Methylation PhosphoSitePlus
S30 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
T34 Phosphorylation PhosphoSitePlus
K35 Acetylation PhosphoSitePlus
K35 Methylation PhosphoSitePlus
K36 Acetylation PhosphoSitePlus
S39 Phosphorylation PhosphoSitePlus
S40 Phosphorylation PhosphoSitePlus
S50 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
K52 Acetylation PhosphoSitePlus
S54 Phosphorylation phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 16083285, 26323318, 18318008, ...18669648, 24275569, 20068231
S58 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 16083285, 15302935, ...18318008, 18669648, 24275569, 19690332, 20068231
S61 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 16083285, 15302935, ...18318008, 18669648, 24275569, 19690332, 20068231
K64 Methylation PhosphoSitePlus
T68 Phosphorylation PhosphoSitePlus
S73 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 20068231, 18318008
S75 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 23186163, 18318008, 18669648, ...24275569, 20068231
S79 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 23186163, 17081983, ...18318008, 18669648, 24275569, 20068231
S97 Phosphorylation PhosphoSitePlus
K98 Acetylation PhosphoSitePlus
K98 Methylation PhosphoSitePlus
S101 Phosphorylation PhosphoSitePlus
K102 Acetylation PhosphoSitePlus
S113 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 23186163, 16097034, 18669648, ...19690332, 20068231
S130 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 20068231, 18669648, 21406692, ...24275569
S132 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 20068231, 18669648, 21406692, ...24275569
S144 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 15302935, 21406692, ...24275569
Y146 Phosphorylation PhosphoSitePlus
S148 Phosphorylation PhosphoSitePlus
S149 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
K168 Acetylation PhosphoSitePlus
K171 Acetylation PhosphoSitePlus
K175 Acetylation PhosphoSitePlus
K175 Methylation PhosphoSitePlus
K175 Ubiquitination PhosphoSitePlus
T177 Phosphorylation PhosphoSitePlus
T179 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 23186163, 16964243, ...15302935, 18669648
S181 Phosphorylation P24941 (CDK2) , P06493 (CDK1) phospho.ELM   PhosphoSitePlus   UniProt 21406692, 23186163, 16964243, ...18847512, 18234856, 15302935, 18669648, 20068231
K184 Acetylation PhosphoSitePlus
K184 Methylation PhosphoSitePlus
K184 Ubiquitination PhosphoSitePlus
K186 Methylation PhosphoSitePlus
K188 Acetylation PhosphoSitePlus
K188 Ubiquitination PhosphoSitePlus
T193 Phosphorylation PhosphoSitePlus
K196 Acetylation PhosphoSitePlus
K196 Ubiquitination PhosphoSitePlus
S198 Phosphorylation PhosphoSitePlus
T202 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 23186163, 16964243, ...18669648, 20068231
S204 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 23186163, 16964243, ...15302935, 18669648, 20068231
S214 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 17287340, 16964243, ...15302935, 18318008, 19367720, 18669648, 24275569, 23186163, 20068231, 17081983
K218 Methylation PhosphoSitePlus
T220 Phosphorylation PhosphoSitePlus
S221 Phosphorylation phospho.ELM   PhosphoSitePlus 15302935
T222 Phosphorylation PhosphoSitePlus
S223 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 15302935, 20068231, ...24275569
S229 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 17081983, 15302935, ...18318008, 18669648, 20068231
S234 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 21406692, 20068231, ...18318008
S240 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 17081983, 18318008, ...18669648, 20068231
Site PTM Type PTM Enzyme Score Source PMID
S2 Phosphorylation HPRD 18452278
Y13 Phosphorylation HPRD 20058876
S14 Phosphorylation HPRD 17525332, 19562805, 18077418, ...20058876, 19651622, 18669648, 20166139, 20068231
S19 Phosphorylation HPRD 19413330, 18691976, 19664994, ...18491316, 20230923, 19562805, 18767875, 18077418, 17693683, 20058876, 19664995, 18452278, 19651622, 15302935, 18669648, 18707149, 20166139, 18491381, 15345747, 19415658, 20068231
Y26 Phosphorylation HPRD 18669648
S30 Phosphorylation HPRD 18669648, 19415658
T34 Phosphorylation HPRD 18491381, 20058876
S39 Phosphorylation HPRD 20068231
S40 Phosphorylation HPRD 18491381, 17081983, 20068231
S54 Phosphorylation HPRD 19651622, 20166139, 18491381, ...17081983, 20068231
S58 Phosphorylation HPRD 18212344, 15302935, 19651622, ...20166139, 18491381, 19415658, 20068231
S61 Phosphorylation HPRD 17081983, 19651622, 20166139, ...18491381, 19415658, 20068231, 18212344
T68 Phosphorylation HPRD 19651622
S73 Phosphorylation HPRD 19651622, 20166139, 18669648, ...17081983, 20068231
S75 Phosphorylation HPRD 17081983, 19651622, 18669648, ...20166139, 18491381, 20068231
S79 Phosphorylation HPRD 17081983, 19651622, 18669648, ...20166139, 18491381, 20068231
S97 Phosphorylation HPRD 17924679
S101 Phosphorylation HPRD 17924679
S113 Phosphorylation HPRD 19413330, 19664994, 18452278, ...19651622, 18669648, 18491381, 15345747, 19415658, 20068231
S130 Phosphorylation HPRD 17081983, 18452278, 19651622, ...18669648, 18491381, 20068231
S132 Phosphorylation HPRD 17081983, 18452278, 19651622, ...18669648, 18491381, 20068231
S144 Phosphorylation HPRD 15302935, 18452278, 19651622, ...18669648, 20166139, 18491381, 19415658, 20068231
Y146 Phosphorylation HPRD 19651622, 18452278
S149 Phosphorylation HPRD 18669648
T177 Phosphorylation HPRD 19413330, 17081983
T179 Phosphorylation HPRD 19413330, 18491316, 18212344, ...16964243, 18767875, 15302935, 19651622, 18669648, 18491381, 19415658, 20068231, 17924679
S181 Phosphorylation HPRD 19413330, 18491316, 18212344, ...16964243, 18767875, 15302935, 19664995, 19651622, 19664994, 18669648, 20166139, 18491381, 19415658, 20068231, 17924679
T202 Phosphorylation HPRD 19651622, 18669648, 16964243, ...20068231, 17081983
S204 Phosphorylation HPRD 16964243, 18767875, 15302935, ...19651622, 18669648, 20068231
S214 Phosphorylation HPRD 19413330, 18491316, 17287340, ...16964243, 18767875, 15302935, 18452278, 19651622, 18669648, 20058876, 18707149, 20166139, 18491381, 20068231
T220 Phosphorylation HPRD 20166139, 17081983
S221 Phosphorylation HPRD 19651622, 20166139, 17081983, ...20068231
T222 Phosphorylation HPRD 19651622
S223 Phosphorylation HPRD 19651622, 20166139, 15302935, ...20068231
S229 Phosphorylation HPRD 19413330, 18669648, 15302935, ...20068231
S234 Phosphorylation HPRD 19413330, 18669648, 17081983, ...20068231
S240 Phosphorylation HPRD 19413330, 19651622, 18669648, ...17081983, 20068231


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S14 P14 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]
Y26 D26 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
R28 I28 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S30 L30 Biomuta DOID:4159 / skin cancer [ cosmic ] DOID:9256 / colorectal cancer [ cosmic, icgc ]
S39 * Biomuta DOID:11054 / urinary bladder cancer [ cosmic ]
S73 Y73 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
K102 N102 Biomuta DOID:2394 / ovarian cancer [ cosmic, icgc ]
S132 R132 Biomuta DOID:3571 / liver cancer [ cosmic ]
S148 R148 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S149 L149 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ] DOID:9256 / colorectal cancer [ cosmic, icgc ]
S149 T149 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]
T179 M179 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K188 * Biomuta DOID:3571 / liver cancer [ cosmic ]
T193 I193 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S198 A198 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S214 I214 Biomuta DOID:1324 / lung cancer [ cosmic ]
S214 T214 Biomuta DOID:10283 / prostate cancer [ icgc ]
K218 R218 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S221 C221 Biomuta DOID:5041 / esophageal cancer [ cosmic ]
S223 R223 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
S223 I223 Biomuta DOID:4159 / skin cancer [ cosmic ]
S229 C229 Biomuta DOID:3571 / liver cancer [ cosmic ]
S234 T234 Biomuta DOID:10534 / stomach cancer [ cosmic ]