iPTMnet Report for Q9H1A4 (ANAPC1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9H1A4 / APC1_HUMAN
Protein Name Anaphase-promoting complex subunit 1
Gene Name Name: ANAPC1
Synonyms:TSG24;
Organism Homo sapiens (Human)

PRO ID PR:Q9H1A4
DAG View
PRO Name anaphase-promoting complex subunit 1 (human)
Definition An anaphase-promoting complex subunit 1 that is encoded in the genome of human.
Short Label hANAPC1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9H1A4 (ANAPC1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K29 Ubiquitination PhosphoSitePlus
S46 Phosphorylation PhosphoSitePlus
S50 Phosphorylation HPRD   PhosphoSitePlus 20068231
S51 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 22067460, 18669648, 20068231
S60 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 22067460, 18669648, 19690332, ...20068231
T65 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 22067460, 18669648
K69 Ubiquitination PhosphoSitePlus
K71 Ubiquitination PhosphoSitePlus
K107 Ubiquitination PhosphoSitePlus
T118 Phosphorylation PhosphoSitePlus
K137 Ubiquitination PhosphoSitePlus
K140 Ubiquitination PhosphoSitePlus
S202 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 14657031, 19691289, 22067460
S233 Phosphorylation PhosphoSitePlus
K245 Ubiquitination PhosphoSitePlus
K275 Ubiquitination PhosphoSitePlus
K284 Ubiquitination PhosphoSitePlus
S286 O-Glycosylation GlyGen 23301498, 35289036, 30059200, ...35254053
S286 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 14657031, 19691289, 22067460
T291 Phosphorylation P53350 (PLK1) , P06493 (CDK1) HPRD   phospho.ELM   PhosphoSitePlus   UniProt 23186163, 22067460, 14657031, ...18669648, 20068231
S298 O-Glycosylation GlyGen 23301498, 35289036, 30059200, ...35254053
S299 O-Glycosylation GlyGen 34846842
S299 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18669648, 20068231
S300 Phosphorylation PhosphoSitePlus
S307 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18669648
S309 Phosphorylation PhosphoSitePlus
K310 Ubiquitination PhosphoSitePlus
S313 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 22067460, 18669648, 23186163
T316 Phosphorylation phospho.ELM   PhosphoSitePlus 22067460
S317 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 22067460, 18669648
S324 Phosphorylation PhosphoSitePlus
T332 Phosphorylation PhosphoSitePlus
S333 Phosphorylation phospho.ELM   PhosphoSitePlus 22067460
S334 Phosphorylation phospho.ELM   PhosphoSitePlus 22067460
S336 Phosphorylation PhosphoSitePlus
S339 Phosphorylation phospho.ELM   PhosphoSitePlus 22067460
S341 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 18691976, 19007248, 19691289, ...18669648, 20068231
S343 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 22067460, 23186163, 18212344, ...19691289
S345 Phosphorylation PhosphoSitePlus
S351 Phosphorylation phospho.ELM   PhosphoSitePlus 22067460
R352 Methylation PhosphoSitePlus
S355 Phosphorylation P06493 (CDK1) , P53350 (PLK1) HPRD   neXtProt   phospho.ELM   PhosphoSitePlus   Signor   UniProt 22067460, 23186163, 18220336, ...19691289, 19651622, 14657031, 18669648, 20068231
S362 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 23186163, 18220336, 22067460, ...18669648, 20068231
S364 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 14657031, 18669648, 20068231, ...22067460
S372 Phosphorylation HPRD   PhosphoSitePlus 16964243, 20068231
S373 Phosphorylation P53350 (PLK1) , P06493 (CDK1) phospho.ELM   PhosphoSitePlus   UniProt 14657031
S377 Phosphorylation P53350 (PLK1) , P06493 (CDK1) HPRD   phospho.ELM   PhosphoSitePlus   UniProt 18691976, 21406692, 23186163, ...16964243, 18220336, 22067460, 19691289, 19651622, 14657031, 17322306, 20068231
K379 Ubiquitination PhosphoSitePlus
S386 Phosphorylation phospho.ELM   PhosphoSitePlus 22067460
K429 Ubiquitination PhosphoSitePlus
C454 Methylation IEDB 31844290
K463 Ubiquitination PhosphoSitePlus
K477 Ubiquitination PhosphoSitePlus
S518 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 22067460, 20068231
T520 Phosphorylation P53350 (PLK1) HPRD   phospho.ELM   PhosphoSitePlus 14657031, 18669648, 20068231
S522 Phosphorylation phospho.ELM   PhosphoSitePlus 22067460
T524 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 22067460, 18669648
S529 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 22067460, 18669648
T530 Phosphorylation P06493 (CDK1) , P53350 (PLK1) HPRD   phospho.ELM   PhosphoSitePlus 14657031, 18669648, 22067460
S536 Phosphorylation phospho.ELM   PhosphoSitePlus 22067460
T537 Phosphorylation P06493 (CDK1) phospho.ELM   PhosphoSitePlus   UniProt 14657031, 22067460
K539 Ubiquitination PhosphoSitePlus
S542 Phosphorylation PhosphoSitePlus
S547 Phosphorylation P06493 (CDK1) , P53350 (PLK1) HPRD   phospho.ELM   PhosphoSitePlus   UniProt 18691976, 22067460, 19651622, ...14657031, 18669648, 19690332, 20068231
S555 Phosphorylation P06493 (CDK1) HPRD   IEDB   phospho.ELM   PhosphoSitePlus   UniProt 18691976, 14657031, 22067460, ...32387766, 19690332, 20068231
S563 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 19651622, 18669648, 20068231
S564 Phosphorylation HPRD   PhosphoSitePlus 19651622
K565 Ubiquitination PhosphoSitePlus
S569 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 14657031, 18669648, 18220336, ...22067460
Y571 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 14657031, 22067460
S586 Phosphorylation PhosphoSitePlus
T596 Phosphorylation PhosphoSitePlus
S600 Phosphorylation PhosphoSitePlus
S686 Phosphorylation P53350 (PLK1) HPRD   phospho.ELM   PhosphoSitePlus   UniProt 18691976, 14657031, 16565220, ...19651622, 22067460, 18669648, 20068231
S688 Phosphorylation P06493 (CDK1) , P53350 (PLK1) HPRD   phospho.ELM   PhosphoSitePlus   UniProt 18691976, 21406692, 15302935, ...23186163, 22067460, 18767875, 19664994, 19664995, 18452278, 19651622, 14657031, 18669648, 19690332, 24275569, 16565220, 19415658, 20068231
K694 Ubiquitination PhosphoSitePlus
K695 Ubiquitination PhosphoSitePlus
S699 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 22067460, 18669648, 19413330, ...18691976
T701 Phosphorylation P06493 (CDK1) , P53350 (PLK1) HPRD   phospho.ELM   PhosphoSitePlus 14657031, 18669648, 17081983
S703 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 22067460, 18669648, 17081983
S727 Phosphorylation HPRD   PhosphoSitePlus 19691289
S731 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 14657031, 15302935, 19691289, ...22067460
S876 Phosphorylation PhosphoSitePlus
S886 Phosphorylation PhosphoSitePlus
S892 Phosphorylation PhosphoSitePlus
K905 Ubiquitination PhosphoSitePlus
S916 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 22067460, 23186163
S920 Phosphorylation PhosphoSitePlus
S922 Phosphorylation PhosphoSitePlus
S984 Phosphorylation PhosphoSitePlus
K985 Ubiquitination PhosphoSitePlus
K994 Ubiquitination PhosphoSitePlus
S1058 Phosphorylation PhosphoSitePlus
K1066 Ubiquitination PhosphoSitePlus
K1162 Ubiquitination PhosphoSitePlus
K1346 Ubiquitination PhosphoSitePlus
S1347 Phosphorylation phospho.ELM   PhosphoSitePlus 22067460
S1349 Phosphorylation PhosphoSitePlus
C1469 Methylation IEDB 31844290
Y1552 Phosphorylation PhosphoSitePlus
Y1610 Phosphorylation PhosphoSitePlus
R1617 Methylation PhosphoSitePlus
Y1638 Phosphorylation PhosphoSitePlus
K1648 Ubiquitination PhosphoSitePlus
K1664 Ubiquitination PhosphoSitePlus
K1688 Ubiquitination PhosphoSitePlus
K1693 Ubiquitination PhosphoSitePlus
Y1698 Phosphorylation PhosphoSitePlus
K1700 Ubiquitination PhosphoSitePlus
S1707 Phosphorylation PhosphoSitePlus
K1709 Ubiquitination PhosphoSitePlus
C1755 Methylation IEDB 31844290


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K29 N29 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S286 Y286 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ]
S313 P313 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
S317 L317 Biomuta DOID:4159 / skin cancer [ cosmic ]
S341 L341 Biomuta DOID:363 / uterine cancer [ icgc ] DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
S355 F355 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S362 A362 Biomuta DOID:1324 / lung cancer [ cosmic ]
S362 F362 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S372 * Biomuta DOID:10283 / prostate cancer [ cosmic ] DOID:1324 / lung cancer [ cosmic ]
K379 * Biomuta DOID:4159 / skin cancer [ cosmic ]
S386 Y386 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
K429 T429 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
C454 R454 Biomuta DOID:10534 / stomach cancer [ cosmic ]
K463 T463 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
T537 A537 Biomuta [ cosmic ] DOID:10283 / prostate cancer [ cosmic ] DOID:1324 / lung cancer [ cosmic ] DOID:363 / uterine cancer [ cosmic ] DOID:5041 / esophageal cancer [ cosmic ] DOID:9256 / colorectal cancer [ cosmic ] DOID:4159 / skin cancer [ cosmic ] DOID:10534 / stomach cancer [ cosmic ] DOID:263 / kidney cancer [ cosmic ] DOID:1319 / brain cancer [ cosmic ]
S555 F555 Biomuta DOID:4159 / skin cancer [ cosmic ]
S564 L564 Biomuta DOID:4159 / skin cancer [ cosmic ]
T596 I596 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S703 F703 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S892 F892 Biomuta [ cosmic ]
K905 Q905 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S922 F922 Biomuta DOID:4159 / skin cancer [ cosmic ] DOID:1612 / breast cancer [ cosmic, icgc ]
S1058 R1058 Biomuta DOID:1324 / lung cancer [ cosmic ]
C1469 F1469 Biomuta DOID:4159 / skin cancer [ cosmic ]
Y1552 C1552 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
Y1552 D1552 Biomuta DOID:4159 / skin cancer [ cosmic ]
Y1552 * Biomuta DOID:4159 / skin cancer [ cosmic ]
K1648 * Biomuta DOID:3571 / liver cancer [ cosmic ]
K1688 N1688 Biomuta DOID:1319 / brain cancer [ cosmic ]
K1693 N1693 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]