iPTMnet Report for Q9H0K1 (SIK2)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9H0K1 / SIK2_HUMAN
Protein Name Serine/threonine-protein kinase SIK2
Gene Name Name: SIK2
Synonyms:KIAA0781;
Organism Homo sapiens (Human)

PRO ID PR:Q9H0K1
DAG View
PRO Name serine/threonine-protein kinase SIK2 (human)
Definition A serine/threonine-protein kinase SIK2 that is encoded in the genome of human.
Short Label hSIK2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9H0K1 (SIK2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
T25 Phosphorylation PhosphoSitePlus   UniProt 19369195
K28 Ubiquitination PhosphoSitePlus
K43 Ubiquitination PhosphoSitePlus
K49 Ubiquitination PhosphoSitePlus
K53 Acetylation PhosphoSitePlus   UniProt 23322770
K53 Ubiquitination PhosphoSitePlus
K63 Ubiquitination PhosphoSitePlus
K81 Ubiquitination PhosphoSitePlus
S90 Phosphorylation PhosphoSitePlus
K144 Ubiquitination PhosphoSitePlus
K168 Sumoylation PhosphoSitePlus
T175 Phosphorylation Q15831 (STK11) phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 14976552, 27441650
K266 Ubiquitination PhosphoSitePlus
K313 Ubiquitination PhosphoSitePlus
S342 Phosphorylation PhosphoSitePlus
S343 Phosphorylation PhosphoSitePlus   RLIMS-P 22462548, 27807598, 27759007
S358 Phosphorylation P31751 (AKT2) , P17612 (PRKACA) neXtProt   PhosphoSitePlus   RLIMS-P 25472719, 27759007, 31794565, ...22462548, 17805301, 27807598, 27441650
T359 Phosphorylation PhosphoSitePlus
T376 Phosphorylation PhosphoSitePlus
S379 Phosphorylation PhosphoSitePlus
T484 Phosphorylation PhosphoSitePlus   RLIMS-P   UniProt 30586628, 22462548, 27441650, ...27807598, 27759007, 23196462
S486 Phosphorylation PhosphoSitePlus
S512 Phosphorylation PhosphoSitePlus
S534 Phosphorylation PhosphoSitePlus
K536 Ubiquitination PhosphoSitePlus
S545 Phosphorylation PhosphoSitePlus
R547 Methylation PhosphoSitePlus
S576 Phosphorylation PhosphoSitePlus
S587 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 23186163, 18220336, 22462548, ...31794565, 18669648, 24275569, 20166139, 19690332
T589 Phosphorylation PhosphoSitePlus
S590 Phosphorylation PhosphoSitePlus
K686 Ubiquitination PhosphoSitePlus
K692 Ubiquitination PhosphoSitePlus
Y700 Phosphorylation PhosphoSitePlus
K702 Ubiquitination PhosphoSitePlus


Q9H0K1 (SIK2) as PTM Enzyme



Substrate Site Score Source PMID
P35568 (IRS1) S794 HPRD   Signor 12624099
Q15078 (CDK5R1) S91 PhosphoSitePlus   Signor 24561619
Q53ET0 (CRTC2) S171 HPRD   Signor 15454081, 16308421, 18669648, ...20577053
Q9BV73 (CEP250) S2392 PhosphoSitePlus   Signor 20708153
Q9BV73 (CEP250) S2394 PhosphoSitePlus   Signor 20708153


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K49 Q49 Biomuta DOID:9256 / colorectal cancer [ icgc ]
K81 N81 Biomuta DOID:4362 / cervical cancer [ cosmic, icgc ]
K266 * Biomuta DOID:1324 / lung cancer [ cosmic ]
S379 L379 Biomuta DOID:263 / kidney cancer [ cosmic ]
R547 H547 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
R547 S547 Biomuta DOID:10283 / prostate cancer [ cosmic ]