iPTMnet Report for Q9H0D6 (XRN2)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9H0D6 / XRN2_HUMAN
Protein Name 5'-3' exoribonuclease 2
Gene Name Name: XRN2
Organism Homo sapiens (Human)

PRO ID PR:Q9H0D6
DAG View
PRO Name 5'-3' exoribonuclease 2 (human)
Definition A 5'-3' exoribonuclease 2 that is encoded in the genome of human.
Short Label hXRN2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9H0D6 (XRN2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K40 Ubiquitination PhosphoSitePlus
Y99 Phosphorylation PhosphoSitePlus
R120 Methylation PhosphoSitePlus
K123 Ubiquitination PhosphoSitePlus
K132 Sumoylation PhosphoSitePlus
K132 Ubiquitination PhosphoSitePlus
K142 Ubiquitination PhosphoSitePlus
K152 Ubiquitination PhosphoSitePlus
K172 Ubiquitination PhosphoSitePlus
Y176 Phosphorylation PhosphoSitePlus
Y177 Phosphorylation PhosphoSitePlus
K189 Ubiquitination PhosphoSitePlus
K207 Ubiquitination PhosphoSitePlus
C228 Methylation IEDB 31844290
C263 Methylation IEDB 31844290
K286 Ubiquitination PhosphoSitePlus
K368 Ubiquitination PhosphoSitePlus
K373 Ubiquitination PhosphoSitePlus
T374 Phosphorylation PhosphoSitePlus
T379 Phosphorylation PhosphoSitePlus
T433 Phosphorylation PhosphoSitePlus
S435 Phosphorylation PhosphoSitePlus
T439 Phosphorylation P50750 (CDK9) , P50613 (CDK7) , P28482 (MAPK1) neXtProt   phospho.ELM   PhosphoSitePlus   Signor   UniProt 22028470, 23186163, 26728557, ...18669648, 24275569
S445 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S448 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 19369195, 21406692, 23186163, ...17081983, 18691976, 18220336, 15302935, 18669648, 24275569, 17924679, 19690332, 20068231, 16964243
S451 Phosphorylation PhosphoSitePlus
S455 Phosphorylation phospho.ELM   PhosphoSitePlus 16964243
R458 Methylation PhosphoSitePlus
Y462 Phosphorylation PhosphoSitePlus
R465 Methylation PhosphoSitePlus
S470 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S471 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 19690332
S473 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 19690332
S475 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 19690332
T478 Phosphorylation PhosphoSitePlus
S479 Phosphorylation PhosphoSitePlus
T481 Phosphorylation PhosphoSitePlus
S485 Phosphorylation PhosphoSitePlus
S487 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163
K493 Ubiquitination PhosphoSitePlus
S499 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 19369195, 21406692, 16083285, ...23186163, 17081983, 15302935, 18318008, 18669648, 24275569, 19690332, 20068231
S501 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 19369195, 21406692, 16083285, ...23186163, 17081983, 15302935, 18318008, 18669648, 24275569, 20068231
K517 Ubiquitination PhosphoSitePlus
K524 Methylation PhosphoSitePlus
K524 Ubiquitination PhosphoSitePlus
K533 Ubiquitination PhosphoSitePlus
K537 Ubiquitination PhosphoSitePlus
K616 Ubiquitination PhosphoSitePlus
K640 Acetylation PhosphoSitePlus
K640 Ubiquitination PhosphoSitePlus
K641 Acetylation PhosphoSitePlus
K641 Ubiquitination PhosphoSitePlus
Y666 Phosphorylation PhosphoSitePlus
S678 Phosphorylation PhosphoSitePlus   UniProt 23186163
K756 Ubiquitination PhosphoSitePlus
Y764 Phosphorylation PhosphoSitePlus
K767 Ubiquitination PhosphoSitePlus
K776 Ubiquitination PhosphoSitePlus
K782 Ubiquitination PhosphoSitePlus
S789 Phosphorylation PhosphoSitePlus
S790 Phosphorylation PhosphoSitePlus
K796 Acetylation PhosphoSitePlus
K796 Ubiquitination PhosphoSitePlus
R806 Methylation PhosphoSitePlus
R816 Methylation PhosphoSitePlus
R824 Methylation PhosphoSitePlus   UniProt 24129315
R847 Methylation PhosphoSitePlus   UniProt 24129315
R851 Methylation PhosphoSitePlus   UniProt 24129315
K858 Methylation PhosphoSitePlus
S861 Phosphorylation PhosphoSitePlus
R864 Methylation PhosphoSitePlus
R870 Methylation PhosphoSitePlus
R880 Methylation PhosphoSitePlus
R883 Methylation PhosphoSitePlus   UniProt 24129315
R895 Methylation PhosphoSitePlus   UniProt 24129315
R921 Methylation PhosphoSitePlus
R922 Methylation PhosphoSitePlus
R925 Methylation PhosphoSitePlus
R928 Methylation PhosphoSitePlus
Y931 Phosphorylation PhosphoSitePlus
R933 Methylation PhosphoSitePlus
R936 Methylation PhosphoSitePlus
R946 Methylation PhosphoSitePlus   UniProt 24129315
Site PTM Type PTM Enzyme Score Source PMID
T433 Phosphorylation HPRD 20068231
T439 Phosphorylation HPRD 18669648, 20068231
S445 Phosphorylation HPRD 18669648, 17081983, 20068231
S448 Phosphorylation HPRD 19413330, 18691976, 16964243, ...15302935, 19664995, 19007248, 19651622, 18669648, 17924679, 20068231, 20068230
S455 Phosphorylation HPRD 16964243
S470 Phosphorylation HPRD 18669648
S471 Phosphorylation HPRD 18669648, 20068231
S473 Phosphorylation HPRD 19413330, 18669648, 19664995
S475 Phosphorylation HPRD 19413330, 19651622, 18669648, ...19664995, 20068231
S479 Phosphorylation HPRD 20058876, 20068231
T481 Phosphorylation HPRD 20058876
S487 Phosphorylation HPRD 18669648, 19664995
S499 Phosphorylation HPRD 19413330, 18491316, 18767875, ...15302935, 18452278, 19651622, 18669648, 20166139, 19415658, 20068231
S501 Phosphorylation HPRD 19413330, 18491316, 18767875, ...15302935, 18452278, 19651622, 18669648, 20166139, 19415658, 20068231
S861 Phosphorylation HPRD 20068231


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
R120 M120 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K123 E123 Biomuta DOID:4606 / bile duct cancer [ cosmic ]
K142 R142 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
R465 M465 Biomuta DOID:1324 / lung cancer [ cosmic ]
S470 Y470 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S473 L473 Biomuta DOID:9256 / colorectal cancer [ cosmic ] DOID:3571 / liver cancer [ cosmic ]
T478 P478 Biomuta DOID:1324 / lung cancer [ cosmic ]
S479 T479 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S479 R479 Biomuta DOID:10534 / stomach cancer [ cosmic ]
S487 P487 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S499 N499 Biomuta DOID:2394 / ovarian cancer [ cosmic, icgc ]
K616 E616 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
K640 N640 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S678 N678 Biomuta DOID:363 / uterine cancer [ icgc ]
K782 E782 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S789 C789 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
K796 M796 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
R851 K851 Biomuta DOID:4606 / bile duct cancer [ cosmic ]
R870 Q870 Biomuta DOID:5041 / esophageal cancer [ cosmic, icgc ]
R895 W895 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
R895 Q895 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ]
R895 L895 Biomuta DOID:1324 / lung cancer [ cosmic ]
R925 H925 Biomuta DOID:9256 / colorectal cancer [ icgc ]
R925 C925 Biomuta DOID:4159 / skin cancer [ cosmic ] DOID:9256 / colorectal cancer [ cosmic ]
Y931 N931 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
Y931 * Biomuta DOID:4159 / skin cancer [ cosmic ]
R933 K933 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
R946 I946 Biomuta DOID:363 / uterine cancer [ icgc ]
R946 K946 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]