iPTMnet Report for Q9C0B1 (FTO)
Protein Information
UniProt AC / UniProt ID | Q9C0B1 / FTO_HUMAN |
Protein Name | Alpha-ketoglutarate-dependent dioxygenase FTO |
Gene Name | Name: FTO Synonyms:KIAA1752; |
Organism | Homo sapiens (Human) |
PRO ID | PR:Q9C0B1 |
PRO Name | alpha-ketoglutarate-dependent dioxygenase FTO (human) |
Definition | An alpha-ketoglutarate-dependent dioxygenase FTO that is encoded in the genome of human. |
Short Label | hFTO |
Category | organism-gene |
Q9C0B1 (FTO) as Substrate
Site | PTM Type | PTM Enzyme | Score | Source | PMID | |
---|---|---|---|---|---|---|
T4 | Phosphorylation | score2 | PhosphoSitePlus UniProt | 23186163 | ||
T6 | Phosphorylation | score1 | PhosphoSitePlus | |||
T32 | Phosphorylation | score1 | PhosphoSitePlus | |||
K45 | Ubiquitination | score1 | PhosphoSitePlus | |||
K48 | Ubiquitination | score1 | PhosphoSitePlus | |||
S55 | Phosphorylation | score1 | PhosphoSitePlus | |||
K88 | Ubiquitination | score1 | PhosphoSitePlus | |||
C104 | Methylation | score1 | IEDB | 31844290 | ||
C104 | S-Nitrosylation | score0 | dbSNO | 19483679 | ||
Y106 | Phosphorylation | score1 | PhosphoSitePlus | |||
K107 | Ubiquitination | score1 | PhosphoSitePlus | |||
Y108 | Phosphorylation | score1 | PhosphoSitePlus | |||
K121 | Ubiquitination | score1 | PhosphoSitePlus | |||
C136 | Methylation | score1 | IEDB | 31844290 | ||
T150 | Phosphorylation | score1 | PhosphoSitePlus | |||
K160 | Ubiquitination | score1 | PhosphoSitePlus | |||
K162 | Ubiquitination | score1 | PhosphoSitePlus | |||
S173 | Phosphorylation | score1 | PhosphoSitePlus | |||
S184 | Phosphorylation | score1 | PhosphoSitePlus | |||
Y185 | Phosphorylation | score1 | PhosphoSitePlus | |||
K194 | Ubiquitination | score1 | PhosphoSitePlus | |||
Y199 | Phosphorylation | score1 | PhosphoSitePlus | |||
K211 | Ubiquitination | score1 | PhosphoSitePlus | |||
K216 | Acetylation | score2 | PhosphoSitePlus UniProt | 19608861 | ||
K216 | Sumoylation | score1 | PhosphoSitePlus | |||
K216 | Ubiquitination | score1 | PhosphoSitePlus | |||
Y220 | Phosphorylation | score1 | PhosphoSitePlus | |||
S229 | Phosphorylation | score1 | PhosphoSitePlus | |||
S240 | O-Glycosylation | score1 | GlyGen | 29351928, 35132862, 34725712, ... | ||
S246 | O-Glycosylation | score1 | GlyGen | 29351928, 35132862, 34725712, ... | ||
S256 | Phosphorylation | score3 | PhosphoSitePlus RLIMS-P | 33925955 | ||
S260 | Phosphorylation | score1 | PhosphoSitePlus | |||
C308 | Methylation | score1 | IEDB | 31844290 | ||
C338 | Methylation | score1 | IEDB | 31844290 | ||
S355 | Phosphorylation | score1 | PhosphoSitePlus | |||
S458 | Phosphorylation | score1 | PhosphoSitePlus |
PTM sites affected in variants
Site | Variant | Source | PMID | Disease [Sample source] |
---|---|---|---|---|
S55 | G55 | Biomuta | DOID:1324 / lung cancer [ cosmic ] | |
C104 | F104 | Biomuta | DOID:1324 / lung cancer [ cosmic, icgc ] | |
Y106 | C106 | Biomuta | DOID:4606 / bile duct cancer [ cosmic ] | |
C136 | S136 | Biomuta | DOID:1612 / breast cancer [ cosmic, icgc ] | |
Y185 | H185 | Biomuta | DOID:9256 / colorectal cancer [ cosmic ] | |
K194 | R194 | Biomuta | DOID:8618 / oral cavity cancer [ cosmic ] | |
S240 | L240 | Biomuta | DOID:4159 / skin cancer [ cosmic ] | |
S246 | I246 | Biomuta | DOID:2394 / ovarian cancer [ cosmic, icgc ] | |
S256 | R256 | Biomuta | DOID:263 / kidney cancer [ cosmic, icgc ] | |
S260 | F260 | Biomuta | DOID:11054 / urinary bladder cancer [ cosmic, icgc ] | |
S260 | C260 | Biomuta | DOID:1324 / lung cancer [ cosmic, icgc ] | |
C308 | F308 | Biomuta | DOID:9256 / colorectal cancer [ cosmic, icgc ] |