iPTMnet Report for Q9C035 (TRIM5)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9C035 / TRIM5_HUMAN
Protein Name Tripartite motif-containing protein 5
Gene Name Name: TRIM5
Synonyms:RNF88;
Organism Homo sapiens (Human)

PRO ID PR:Q9C035
DAG View
PRO Name tripartite motif-containing protein 5 (human)
Definition A tripartite motif-containing protein 5 that is encoded in the genome of human.
Short Label hTRIM5
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9C035 (TRIM5) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
A2 Acetylation UniProt 22223895
S3 Phosphorylation PhosphoSitePlus
K10 Sumoylation PhosphoSitePlus
K45 Ubiquitination PhosphoSitePlus
K50 Ubiquitination PhosphoSitePlus
K79 Ubiquitination PhosphoSitePlus
K84 Sumoylation PhosphoSitePlus
K84 Ubiquitination PhosphoSitePlus
S86 Phosphorylation PhosphoSitePlus   UniProt 23186163
K91 Ubiquitination PhosphoSitePlus
K152 Ubiquitination PhosphoSitePlus
K167 Ubiquitination PhosphoSitePlus
K171 Ubiquitination PhosphoSitePlus
Y176 Phosphorylation PhosphoSitePlus
K178 Ubiquitination PhosphoSitePlus
S197 Phosphorylation PhosphoSitePlus
K205 Ubiquitination PhosphoSitePlus
K212 Ubiquitination PhosphoSitePlus
K255 Ubiquitination PhosphoSitePlus
K264 Ubiquitination PhosphoSitePlus
K270 Ubiquitination PhosphoSitePlus
K282 Ubiquitination PhosphoSitePlus
K324 Ubiquitination PhosphoSitePlus
Y329 Phosphorylation PhosphoSitePlus
K367 Ubiquitination PhosphoSitePlus
S416 Phosphorylation PhosphoSitePlus
K481 Ubiquitination PhosphoSitePlus
S490 Phosphorylation PhosphoSitePlus
S492 Phosphorylation PhosphoSitePlus
S493 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
A2 T2 Biomuta DOID:10534 / stomach cancer [ cosmic ]
A2 V2 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
K50 I50 Biomuta DOID:263 / kidney cancer [ cosmic ]
K79 T79 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S197 R197 Biomuta DOID:4159 / skin cancer [ cosmic ]
K255 T255 Biomuta DOID:1319 / brain cancer [ icgc ]
S492 I492 Biomuta DOID:1324 / lung cancer [ cosmic ]
S492 N492 Biomuta DOID:10534 / stomach cancer [ cosmic ]