iPTMnet Report for Q9BZL4 (PPP1R12C)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9BZL4 / PP12C_HUMAN
Protein Name Protein phosphatase 1 regulatory subunit 12C
Gene Name Name: PPP1R12C
Synonyms:LENG3,MBS85;
Organism Homo sapiens (Human)

PRO ID PR:Q9BZL4
DAG View
PRO Name protein phosphatase 1 regulatory subunit 12C (human)
Definition A protein phosphatase 1 regulatory subunit 12C that is encoded in the genome of human.
Short Label hPPP1R12C
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9BZL4 (PPP1R12C) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S2 Acetylation UniProt 22814378
T46 Phosphorylation PhosphoSitePlus
Y152 Phosphorylation IEDB 35494241
K198 Acetylation IEDB 34357683
K198 Ubiquitination PhosphoSitePlus
T226 O-Glycosylation GlyGen 34019948, 30620550
Y239 Phosphorylation PhosphoSitePlus
S325 Phosphorylation PhosphoSitePlus
S336 Phosphorylation PhosphoSitePlus
S337 Phosphorylation PhosphoSitePlus
S344 Phosphorylation PhosphoSitePlus
K361 Ubiquitination PhosphoSitePlus
S399 Phosphorylation PhosphoSitePlus   UniProt 23186163
S404 Phosphorylation PhosphoSitePlus
S407 Phosphorylation PhosphoSitePlus   UniProt 23186163
S417 Phosphorylation PhosphoSitePlus
T425 Phosphorylation PhosphoSitePlus
S427 Phosphorylation PhosphoSitePlus   UniProt 23186163, 24275569
S428 Phosphorylation PhosphoSitePlus
S450 Phosphorylation PhosphoSitePlus
S452 Phosphorylation PhosphoSitePlus   Signor   UniProt 23186163, 22137581, 26456332
S452 Phosphorylation P54646 (PRKAA2) PhosphoSitePlus   Signor 22137581
S452 Phosphorylation Q13131 (PRKAA1) PhosphoSitePlus 26456332
S453 Phosphorylation PhosphoSitePlus
S454 Phosphorylation PhosphoSitePlus
T459 Phosphorylation PhosphoSitePlus
S460 Phosphorylation PhosphoSitePlus
S476 Phosphorylation PhosphoSitePlus
C494 Methylation IEDB 31844290
S499 Phosphorylation PhosphoSitePlus
S509 Phosphorylation PhosphoSitePlus   UniProt 18847512, 23186163, 24275569
S509 Phosphorylation P24941 (CDK2) PhosphoSitePlus 18847512
S532 Phosphorylation PhosphoSitePlus
S556 Phosphorylation PhosphoSitePlus
S559 Phosphorylation PhosphoSitePlus
T560 Phosphorylation neXtProt   PhosphoSitePlus   UniProt 11399775, 23186163
T560 Phosphorylation Q5VT25 (CDC42BPA) neXtProt 11399775
T564 Phosphorylation PhosphoSitePlus
T566 Phosphorylation PhosphoSitePlus
K573 Acetylation PhosphoSitePlus
K583 Acetylation PhosphoSitePlus
S604 Phosphorylation PhosphoSitePlus   UniProt 18669648, 23186163
S781 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
T425 Phosphorylation HPRD 20058876
S427 Phosphorylation HPRD 20058876
S428 Phosphorylation HPRD 20058876
S450 Phosphorylation HPRD 20166139
S452 Phosphorylation HPRD 19413330
T560 Phosphorylation HPRD 11399775, 18077418
T560 Phosphorylation Q5VT25 (CDC42BPA) HPRD 11399775, 18077418
S604 Phosphorylation HPRD 18669648
Site PTM Type PTM Enzyme Score Source PMID
S399 Phosphorylation PhosphoSitePlus
S404 Phosphorylation PhosphoSitePlus
S407 Phosphorylation PhosphoSitePlus
S603 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S604 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S530 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S336 Y336 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S336 F336 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S454 F454 Biomuta DOID:4159 / skin cancer [ cosmic ]
S499 * Biomuta DOID:363 / uterine cancer [ cosmic ]
S530 I530 Biomuta DOID:363 / uterine cancer [ icgc ]
S530 N530 Biomuta DOID:1793 / pancreatic cancer [ cosmic ]
S559 F559 Biomuta DOID:4159 / skin cancer [ cosmic ]
T560 I560 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]
T564 P564 Biomuta DOID:363 / uterine cancer [ icgc ]
K573 T573 Biomuta DOID:10534 / stomach cancer [ cosmic ]
S604 N604 Biomuta DOID:1793 / pancreatic cancer [ cosmic ]
S604 I604 Biomuta DOID:363 / uterine cancer [ icgc ]