iPTMnet Report for Q9BYJ9 (YTHDF1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9BYJ9 / YTHD1_HUMAN
Protein Name YTH domain-containing family protein 1
Gene Name Name: YTHDF1
Synonyms:C20orf21;
Organism Homo sapiens (Human)

PRO ID PR:Q9BYJ9
DAG View
PRO Name YTH domain-containing family protein 1 (human)
Definition A YTH domain-containing family protein 1 that is encoded in the genome of human.
Short Label hYTHDF1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9BYJ9 (YTHDF1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S2 Acetylation UniProt 19413330, 22814378
S2 Phosphorylation PhosphoSitePlus
S5 Phosphorylation PhosphoSitePlus
K12 Ubiquitination PhosphoSitePlus
Y116 Phosphorylation PhosphoSitePlus
S130 O-Glycosylation GlyGen 23301498, 35138101, 30620550, ...31492838, 37086786, 35289036, 35254053, 22661428, 29237092, 32119511, 21158410, 32574038, 35132862, 20305658, 28657654, 34846842, 33214551, 30379171, 30059200, 29351928, 34019948, 28510447, 20068230
T152 O-Glycosylation GlyGen 23301498, 35138101, 30620550, ...31492838, 37086786, 35289036, 35254053, 22661428, 29237092, 32119511, 21158410, 32574038, 35132862, 20305658, 28657654, 34846842, 33214551, 30379171, 30059200, 29351928, 34019948, 28510447, 20068230
S156 O-Glycosylation GlyGen 23301498, 35138101, 30620550, ...31492838, 37086786, 35289036, 35254053, 22661428, 29237092, 32119511, 21158410, 32574038, 35132862, 20305658, 28657654, 34846842, 33214551, 30379171, 30059200, 29351928, 34019948, 28510447, 20068230
S157 O-Glycosylation GlyGen 23301498, 35138101, 30620550, ...31492838, 37086786, 35289036, 35254053, 22661428, 29237092, 32119511, 21158410, 32574038, 35132862, 20305658, 28657654, 34846842, 33214551, 30379171, 30059200, 29351928, 34019948, 28510447, 20068230
T161 O-Glycosylation GlyGen 23301498, 35138101, 30620550, ...31492838, 37086786, 35289036, 35254053, 22661428, 29237092, 32119511, 21158410, 32574038, 35132862, 20305658, 28657654, 34846842, 33214551, 30379171, 30059200, 29351928, 34019948, 28510447, 20068230
T173 O-Glycosylation GlyGen 23301498, 35138101, 30620550, ...31492838, 37086786, 35289036, 35254053, 22661428, 29237092, 32119511, 21158410, 32574038, 35132862, 20305658, 28657654, 34846842, 33214551, 30379171, 30059200, 29351928, 34019948, 28510447, 20068230
S182 Phosphorylation PhosphoSitePlus   UniProt 23186163
K191 Ubiquitination PhosphoSitePlus
S196 O-Glycosylation GlyGen   PhosphoSitePlus 23301498, 35138101, 30620550, ...31492838, 37086786, 35289036, 35254053, 22661428, 29237092, 32119511, 21158410, 32574038, 35132862, 20305658, 28657654, 34846842, 33214551, 30379171, 30059200, 29351928, 34019948, 28510447, 20068230
S197 O-Glycosylation GlyGen 23301498, 35138101, 30620550, ...31492838, 37086786, 35289036, 35254053, 22661428, 29237092, 32119511, 21158410, 32574038, 35132862, 20305658, 28657654, 34846842, 33214551, 30379171, 30059200, 29351928, 34019948, 28510447, 20068230
S198 O-Glycosylation GlyGen 23301498, 35138101, 30620550, ...31492838, 37086786, 35289036, 35254053, 22661428, 29237092, 32119511, 21158410, 32574038, 35132862, 20305658, 28657654, 34846842, 33214551, 30379171, 30059200, 29351928, 34019948, 28510447, 20068230
S198 Phosphorylation PhosphoSitePlus
T202 O-Glycosylation GlyGen 23301498, 35138101, 30620550, ...31492838, 37086786, 35289036, 35254053, 22661428, 29237092, 32119511, 21158410, 32574038, 35132862, 20305658, 28657654, 34846842, 33214551, 30379171, 30059200, 29351928, 34019948, 28510447, 20068230
S205 O-Glycosylation GlyGen 23301498, 35138101, 30620550, ...31492838, 37086786, 35289036, 35254053, 22661428, 29237092, 32119511, 21158410, 32574038, 35132862, 20305658, 28657654, 34846842, 33214551, 30379171, 30059200, 29351928, 34019948, 28510447, 20068230
S208 O-Glycosylation GlyGen 23301498, 35138101, 30620550, ...31492838, 37086786, 35289036, 35254053, 22661428, 29237092, 32119511, 21158410, 32574038, 35132862, 20305658, 28657654, 34846842, 33214551, 30379171, 30059200, 29351928, 34019948, 28510447, 20068230
S209 O-Glycosylation GlyGen 23301498, 35138101, 30620550, ...31492838, 37086786, 35289036, 35254053, 22661428, 29237092, 32119511, 21158410, 32574038, 35132862, 20305658, 28657654, 34846842, 33214551, 30379171, 30059200, 29351928, 34019948, 28510447, 20068230
T213 O-Glycosylation GlyGen 23301498, 35138101, 30620550, ...31492838, 37086786, 35289036, 35254053, 22661428, 29237092, 32119511, 21158410, 32574038, 35132862, 20305658, 28657654, 34846842, 33214551, 30379171, 30059200, 29351928, 34019948, 28510447, 20068230
T232 O-Glycosylation GlyGen 23301498, 35138101, 30620550, ...31492838, 37086786, 35289036, 35254053, 22661428, 29237092, 32119511, 21158410, 32574038, 35132862, 20305658, 28657654, 34846842, 33214551, 30379171, 30059200, 29351928, 34019948, 28510447, 20068230
K240 Ubiquitination PhosphoSitePlus
S252 Phosphorylation PhosphoSitePlus
K266 Ubiquitination PhosphoSitePlus
T273 Phosphorylation PhosphoSitePlus
S291 Phosphorylation PhosphoSitePlus
R327 Methylation PhosphoSitePlus
S346 Phosphorylation phospho.ELM 18669648
S348 Phosphorylation phospho.ELM 18669648
S350 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S364 Phosphorylation PhosphoSitePlus
K370 Ubiquitination PhosphoSitePlus
K372 Ubiquitination PhosphoSitePlus
K380 Ubiquitination PhosphoSitePlus
K387 Ubiquitination PhosphoSitePlus
K395 Ubiquitination PhosphoSitePlus
S398 Phosphorylation PhosphoSitePlus
S409 Phosphorylation PhosphoSitePlus
S413 Phosphorylation PhosphoSitePlus
K419 Ubiquitination PhosphoSitePlus
K469 Ubiquitination PhosphoSitePlus
K473 Ubiquitination PhosphoSitePlus
R493 Methylation PhosphoSitePlus
K500 Ubiquitination PhosphoSitePlus
K515 Ubiquitination PhosphoSitePlus
K527 Ubiquitination PhosphoSitePlus
K541 Ubiquitination PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S291 Phosphorylation HPRD 18691976, 20068231
Y317 Phosphorylation HPRD 18691976, 20068231
S346 Phosphorylation HPRD 18669648, 20068231
S348 Phosphorylation HPRD 18691976, 18669648, 20068231
S350 Phosphorylation HPRD 18669648, 20068231
Site PTM Type PTM Enzyme Score Source PMID
S39 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
Y116 C116 Biomuta DOID:5041 / esophageal cancer [ cosmic ] DOID:263 / kidney cancer [ cosmic ]
S156 R156 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S157 F157 Biomuta DOID:4159 / skin cancer [ cosmic ]
T173 N173 Biomuta DOID:1324 / lung cancer [ cosmic ]
K191 Q191 Biomuta DOID:3571 / liver cancer [ cosmic ]
S197 F197 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S208 N208 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
K266 R266 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K266 * Biomuta DOID:1793 / pancreatic cancer [ cosmic ]
R327 L327 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
R327 H327 Biomuta DOID:9256 / colorectal cancer [ cosmic ] DOID:10534 / stomach cancer [ cosmic ]
S364 F364 Biomuta DOID:4159 / skin cancer [ cosmic ]
S398 C398 Biomuta DOID:11054 / urinary bladder cancer [ cosmic ]