iPTMnet Report for Q9BYG3 (NIFK)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9BYG3 / MK67I_HUMAN
Protein Name MKI67 FHA domain-interacting nucleolar phosphoprotein
Gene Name Name: NIFK
Synonyms:MKI67IP,NOPP34;
Organism Homo sapiens (Human)

PRO ID PR:Q9BYG3
DAG View
PRO Name MKI67 FHA domain-interacting nucleolar phosphoprotein (human)
Definition An MKI67 FHA domain-interacting nucleolar phosphoprotein that is encoded in the genome of human.
Short Label hNIFK
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9BYG3 (NIFK) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
A2 Acetylation UniProt 19413330, 22223895
K38 Sumoylation PhosphoSitePlus
T82 Phosphorylation PhosphoSitePlus
Y88 Phosphorylation PhosphoSitePlus
R114 Methylation UniProt 26529540
K128 Ubiquitination PhosphoSitePlus
K139 Methylation PhosphoSitePlus
K139 Sumoylation PhosphoSitePlus
K139 Ubiquitination PhosphoSitePlus
S145 Phosphorylation PhosphoSitePlus   UniProt 23186163
T154 Phosphorylation PhosphoSitePlus
T156 Phosphorylation PhosphoSitePlus
K158 Ubiquitination PhosphoSitePlus
K179 Ubiquitination PhosphoSitePlus
Y183 Phosphorylation PhosphoSitePlus
K192 Sumoylation PhosphoSitePlus
K192 Ubiquitination PhosphoSitePlus
T199 Phosphorylation PhosphoSitePlus
S204 Phosphorylation PhosphoSitePlus
K206 Ubiquitination PhosphoSitePlus
S218 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 21406692, 19691289, 19007248, ...18669648, 20068231
T220 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18669648, 19007248, 20068231, ...19691289
T223 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 19413330, 21406692, 19691289, ...23186163, 17081983, 19664994, 19664995, 19007248, 19651622, 18669648, 20068231, 20068230
T227 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18669648, 20068231
S230 Phosphorylation P49841 (GSK3B) , P49840 (GSK3A) HPRD   phospho.ELM   PhosphoSitePlus   UniProt 18669648, 16244663, 19007248, ...20068231
T234 Phosphorylation P49840 (GSK3A) , P49841 (GSK3B) HPRD   IntAct   phospho.ELM   PhosphoSitePlus   UniProt 19413330, 16244663, 17081983, ...18767875, 19007248, 14659764, 16565220, 17322306, 18669648, 17287340, 20068231
C237 S-Nitrosylation dbSNO 26338901
T238 Phosphorylation P06493 (CDK1) HPRD   neXtProt   phospho.ELM   PhosphoSitePlus   UniProt 19413330, 16244663, 17081983, ...18220336, 18767875, 16565220, 17322306, 18669648, 20068231
T240 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18669648, 17287340
R244 Methylation UniProt 26529540
R245 Methylation UniProt 26529540
S247 Phosphorylation HPRD   IEDB   phospho.ELM   PhosphoSitePlus   UniProt 21406692, 17287340, 33936100, ...19007248, 18452278, 19651622, 27920218, 18669648, 23186163, 30784271, 29493099, 27869121
K271 Sumoylation PhosphoSitePlus
T277 Phosphorylation PhosphoSitePlus
T279 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 18669648, 19007248, 19691289
T281 Phosphorylation PhosphoSitePlus
S283 Phosphorylation PhosphoSitePlus
R284 Methylation UniProt 26529540
S290 Phosphorylation PhosphoSitePlus
S291 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
T82 I82 Biomuta DOID:4159 / skin cancer [ cosmic ]
K139 N139 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]
Y183 C183 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
T227 N227 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
R245 Q245 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
R284 Q284 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]