iPTMnet Report for Q9BWF3 (RBM4)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9BWF3 / RBM4_HUMAN
Protein Name RNA-binding protein 4
Gene Name Name: RBM4
Synonyms:RBM4A;
Organism Homo sapiens (Human)

PRO ID PR:Q9BWF3
DAG View
PRO Name RNA-binding protein 4 (human)
Definition An RNA-binding protein 4 that is encoded in the genome of human.
Short Label hRBM4
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9BWF3 (RBM4) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K3 Sumoylation PhosphoSitePlus
K3 Ubiquitination PhosphoSitePlus
K27 Ubiquitination PhosphoSitePlus
K35 Ubiquitination PhosphoSitePlus
Y37 Phosphorylation PhosphoSitePlus
K45 Ubiquitination PhosphoSitePlus
K59 Acetylation PhosphoSitePlus
K59 Ubiquitination PhosphoSitePlus
K71 Sumoylation PhosphoSitePlus
K71 Ubiquitination PhosphoSitePlus
K79 Ubiquitination PhosphoSitePlus
S86 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163
T88 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
C89 Methylation IEDB 31844290
T90 Phosphorylation PhosphoSitePlus
K92 Sumoylation PhosphoSitePlus
K92 Ubiquitination PhosphoSitePlus
K97 Sumoylation PhosphoSitePlus
K97 Ubiquitination PhosphoSitePlus
Y101 Phosphorylation PhosphoSitePlus
K111 Ubiquitination PhosphoSitePlus
Y113 Phosphorylation PhosphoSitePlus
R129 Methylation PhosphoSitePlus
K139 Acetylation PhosphoSitePlus
K139 Ubiquitination PhosphoSitePlus
S160 Phosphorylation PhosphoSitePlus
K173 Sumoylation PhosphoSitePlus
K173 Ubiquitination PhosphoSitePlus
Y190 Phosphorylation phospho.ELM   PhosphoSitePlus 15592455
E192 Methylation IEDB 32357974
Y194 Phosphorylation phospho.ELM   PhosphoSitePlus 15592455
Y201 Phosphorylation PhosphoSitePlus
Y205 Phosphorylation PhosphoSitePlus
S208 O-Glycosylation GlyGen 35008409, 33214551, 35138101, ...34229054, 34019948, 35254053, 35132862, 32119511, 29351928, 31373491
S208 Phosphorylation PhosphoSitePlus
Y210 Phosphorylation PhosphoSitePlus
Y211 Phosphorylation PhosphoSitePlus
Y215 Phosphorylation PhosphoSitePlus
Y221 Phosphorylation PhosphoSitePlus
Y222 Phosphorylation PhosphoSitePlus
K223 Sumoylation PhosphoSitePlus
K223 Ubiquitination PhosphoSitePlus
Y272 Phosphorylation PhosphoSitePlus
T279 O-Glycosylation GlyGen 35008409, 33214551, 35138101, ...34229054, 34019948, 35254053, 35132862, 32119511, 29351928, 31373491
S280 O-Glycosylation GlyGen 35008409, 33214551, 35138101, ...32938750, 34019948, 29351928, 35132862, 31373491, 32119511, 35254053, 34229054
T285 O-Glycosylation GlyGen 35008409, 33214551, 35138101, ...34229054, 34019948, 35254053, 35132862, 32119511, 29351928, 31373491
T297 O-Glycosylation GlyGen 35008409, 33214551, 35138101, ...32938750, 34019948, 29351928, 35132862, 31373491, 32119511, 35254053, 34229054
S300 O-Glycosylation GlyGen 34846842, 33214551, 35138101, ...35008409, 34229054, 34019948, 35254053, 35132862, 32119511, 29351928, 31373491
T301 O-Glycosylation GlyGen 35008409, 33214551, 35138101, ...34229054, 34019948, 35254053, 35132862, 32119511, 29351928, 31373491
T301 Phosphorylation PhosphoSitePlus
S302 O-Glycosylation GlyGen 35008409, 33214551, 35138101, ...34229054, 34019948, 35254053, 35132862, 32119511, 29351928, 31373491
Y303 Phosphorylation PhosphoSitePlus
S309 Phosphorylation Q96SB4 (SRPK1) PhosphoSitePlus   RLIMS-P   UniProt 17284590, 23527094, 23897118
T315 O-Glycosylation GlyGen 35008409, 33214551, 35138101, ...34229054, 34019948, 35254053, 35132862, 32119511, 29351928, 31373491
T320 O-Glycosylation GlyGen 31373491
Y325 Phosphorylation PhosphoSitePlus
Y327 Phosphorylation PhosphoSitePlus
S331 O-Glycosylation GlyGen 35008409, 33214551, 35138101, ...34229054, 34019948, 35254053, 35132862, 32119511, 29351928, 31373491
S331 Phosphorylation PhosphoSitePlus
S334 Phosphorylation PhosphoSitePlus
S337 Phosphorylation PhosphoSitePlus
S343 Phosphorylation PhosphoSitePlus
Y345 Phosphorylation PhosphoSitePlus
Y350 Phosphorylation PhosphoSitePlus
Y355 Phosphorylation PhosphoSitePlus
R358 Methylation PhosphoSitePlus
Y361 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S86 Phosphorylation HPRD 18691976, 18767875, 19664995, ...17322306, 18669648, 19415658, 20068231
T88 Phosphorylation HPRD 17322306, 18767875, 18669648, ...20068231
T90 Phosphorylation HPRD 17081983, 20068231
Y190 Phosphorylation HPRD 15592455
Y194 Phosphorylation HPRD 15592455
S309 Phosphorylation HPRD 20068231
Site PTM Type PTM Enzyme Score Source PMID
R145 Methylation PhosphoSitePlus
K160 Ubiquitination PhosphoSitePlus


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation Q9BWF3 (RBM4) S309 Q9UKV8 (AGO2) unknown eFIP 23897118


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
Y113 N113 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
K223 E223 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
T285 A285 Biomuta DOID:363 / uterine cancer [ icgc ]
T301 S301 Biomuta DOID:1324 / lung cancer [ cosmic, icgc, tcga ]
S337 L337 Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
R358 W358 Biomuta DOID:11054 / urinary bladder cancer [ cosmic ]
R358 L358 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
Y361 H361 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]