iPTMnet Report for Q9BVS4 (RIOK2)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9BVS4 / RIOK2_HUMAN
Protein Name Serine/threonine-protein kinase RIO2
Gene Name Name: RIOK2
Synonyms:RIO2;
Organism Homo sapiens (Human)

PRO ID PR:Q9BVS4
DAG View
PRO Name serine/threonine-protein kinase RIO2 (human)
Definition A serine/threonine-protein kinase RIO2 that is encoded in the genome of human.
Short Label hRIOK2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9BVS4 (RIOK2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K8 Ubiquitination PhosphoSitePlus
T21 Phosphorylation PhosphoSitePlus
K45 Ubiquitination PhosphoSitePlus
K51 Ubiquitination PhosphoSitePlus
K86 Ubiquitination PhosphoSitePlus
T130 Phosphorylation PhosphoSitePlus
S131 Phosphorylation PhosphoSitePlus
K160 Ubiquitination PhosphoSitePlus
Y181 Phosphorylation PhosphoSitePlus
S239 O-Glycosylation GlyGen 30379171, 22564745, 29351928
K270 Ubiquitination PhosphoSitePlus
K275 Ubiquitination PhosphoSitePlus
K288 Ubiquitination PhosphoSitePlus
S332 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18691976, 23186163, 17081983, ...19369195, 18669648, 19690332, 20068231
S335 Phosphorylation P53350 (PLK1) neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 18691976, 23186163, 17081983, ...19369195, 18669648, 21880710, 19690332, 20068231
S337 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18691976, 21406692, 23186163, ...17081983, 19369195, 18669648, 19690332, 20068231
Y348 Phosphorylation PhosphoSitePlus
S350 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163
S354 Phosphorylation PhosphoSitePlus
S362 Phosphorylation PhosphoSitePlus   UniProt 19369195
Y366 Phosphorylation PhosphoSitePlus
S369 Phosphorylation PhosphoSitePlus
S370 Phosphorylation phospho.ELM 18669648
K377 Ubiquitination PhosphoSitePlus
S380 Phosphorylation P53350 (PLK1) neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 18669648, 21880710, 23186163, ...19690332
S382 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 19690332
S385 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 19369195, 18669648, 19690332
S390 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18691976, 23186163, 17081983, ...19369195, 19690332
S412 Phosphorylation PhosphoSitePlus   UniProt 23186163, 20068231
T414 Phosphorylation PhosphoSitePlus
S417 Phosphorylation PhosphoSitePlus   UniProt 18691976
K420 Ubiquitination PhosphoSitePlus
Y426 Phosphorylation PhosphoSitePlus
S442 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18691976, 23186163, 18220336, ...18669648, 19369195
Y445 Phosphorylation PhosphoSitePlus   UniProt 19369195
C449 Methylation IEDB 31844290
S457 Phosphorylation PhosphoSitePlus
T481 Phosphorylation PhosphoSitePlus
S483 Phosphorylation PhosphoSitePlus
T485 Phosphorylation PhosphoSitePlus
S486 Phosphorylation PhosphoSitePlus
S487 Phosphorylation PhosphoSitePlus
S489 Phosphorylation PhosphoSitePlus
T510 Phosphorylation PhosphoSitePlus
K523 Ubiquitination PhosphoSitePlus
K531 Methylation PhosphoSitePlus
K531 Ubiquitination PhosphoSitePlus
S548 Phosphorylation P53350 (PLK1) neXtProt   PhosphoSitePlus   RLIMS-P   UniProt 21880710
Site PTM Type PTM Enzyme Score Source PMID
S332 Phosphorylation HPRD 19413330, 18691976, 17081983, ...18452278, 19651622, 18669648, 20068231
S335 Phosphorylation HPRD 18691976, 17081983, 18767875, ...18452278, 18669648, 20068231
S337 Phosphorylation HPRD 19413330, 18691976, 18767875, ...19664994, 18452278, 17322306, 18669648, 19651622, 19415658, 20068231
S350 Phosphorylation HPRD 19651622, 18691976, 18669648, ...19007248
S369 Phosphorylation HPRD 18691976
S370 Phosphorylation HPRD 18669648
S380 Phosphorylation HPRD 19651622, 18691976, 18669648, ...17081983
S382 Phosphorylation HPRD 19651622, 18691976, 18669648, ...17081983
S385 Phosphorylation HPRD 19651622, 18691976, 18669648, ...17081983
S390 Phosphorylation HPRD 18691976, 17081983
S412 Phosphorylation HPRD 20068231
S417 Phosphorylation HPRD 18691976
S442 Phosphorylation HPRD 18691976, 18669648
S492 Phosphorylation HPRD 17081983
S494 Phosphorylation HPRD 17081983
T495 Phosphorylation HPRD 17081983


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K51 E51 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S131 P131 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]
Y181 C181 Biomuta DOID:3571 / liver cancer [ cosmic ]
K288 N288 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S332 Y332 Biomuta [ cosmic ]
S335 L335 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]
S354 R354 Biomuta DOID:3571 / liver cancer [ cosmic ]
S362 A362 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S369 A369 Biomuta DOID:4159 / skin cancer [ cosmic ]
Y426 D426 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
T485 A485 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S494 L494 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
S494 * Biomuta DOID:363 / uterine cancer [ cosmic ]