iPTMnet Report for Q9BTA9 (WAC)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9BTA9 / WAC_HUMAN
Protein Name WW domain-containing adapter protein with coiled-coil
Gene Name Name: WAC
Synonyms:KIAA1844;
Organism Homo sapiens (Human)

PRO ID PR:Q9BTA9
DAG View
PRO Name WW domain-containing adapter protein with coiled-coil (human)
Definition A WW domain-containing adapter protein with coiled-coil that is encoded in the genome of human.
Short Label hWAC
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9BTA9 (WAC) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S12 Phosphorylation PhosphoSitePlus
R19 Methylation PhosphoSitePlus
S22 Phosphorylation PhosphoSitePlus
Y25 Phosphorylation PhosphoSitePlus
K29 Methylation PhosphoSitePlus
K29 Ubiquitination PhosphoSitePlus
S53 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 23186163, 16964243, 20068231, ...17081983
S62 Phosphorylation PhosphoSitePlus
S64 Phosphorylation phospho.ELM   PhosphoSitePlus 17081983
Y69 Phosphorylation PhosphoSitePlus
S70 Phosphorylation PhosphoSitePlus
S72 Phosphorylation PhosphoSitePlus
K79 Methylation PhosphoSitePlus
T93 Phosphorylation PhosphoSitePlus
S96 Phosphorylation PhosphoSitePlus
S131 Phosphorylation PhosphoSitePlus   UniProt 23186163
S136 Phosphorylation PhosphoSitePlus
S142 Phosphorylation PhosphoSitePlus   UniProt 23186163
K144 Ubiquitination PhosphoSitePlus
S180 Phosphorylation PhosphoSitePlus
Y187 Phosphorylation PhosphoSitePlus
T195 Phosphorylation PhosphoSitePlus
T197 Phosphorylation PhosphoSitePlus
S198 Phosphorylation PhosphoSitePlus
S202 Phosphorylation PhosphoSitePlus
S225 O-Glycosylation GlyGen 23301498, 33214551, 35138101, ...34019948, 32574038, 30059200, 35254053, 35132862, 31492838, 35289036, 29237092
S225 Phosphorylation PhosphoSitePlus   UniProt 23186163
T244 Phosphorylation P06493 (CDK1) PhosphoSitePlus   Signor 30021153
S261 Phosphorylation PhosphoSitePlus
S265 Phosphorylation PhosphoSitePlus
S266 Phosphorylation PhosphoSitePlus
K278 Ubiquitination PhosphoSitePlus
S279 Phosphorylation PhosphoSitePlus
S286 Phosphorylation PhosphoSitePlus
T287 Phosphorylation PhosphoSitePlus
S289 Phosphorylation PhosphoSitePlus
T293 O-Glycosylation GlyGen 23301498, 33214551, 35138101, ...34019948, 32574038, 30059200, 35254053, 35132862, 31492838, 35289036, 29237092
T293 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 16964243, ...24275569
K302 Acetylation PhosphoSitePlus   UniProt 19608861
T303 O-Glycosylation GlyGen 23301498, 33214551, 35138101, ...34019948, 32574038, 30059200, 35254053, 35132862, 31492838, 35289036, 29237092
T303 Phosphorylation PhosphoSitePlus
S308 O-Glycosylation GlyGen 23301498, 33214551, 35138101, ...34019948, 32574038, 30059200, 35254053, 35132862, 31492838, 35289036, 29237092
S308 Phosphorylation PhosphoSitePlus
T309 Phosphorylation PhosphoSitePlus
S310 Phosphorylation PhosphoSitePlus
S346 Phosphorylation PhosphoSitePlus
S351 Phosphorylation PhosphoSitePlus
T391 O-Glycosylation GlyGen 23301498, 33214551, 35138101, ...34019948, 32574038, 30059200, 35254053, 35132862, 31492838, 35289036, 29237092
T395 O-Glycosylation GlyGen 23301498, 33214551, 35138101, ...32574038, 32938750, 34019948, 30059200, 35132862, 31492838, 35289036, 35254053, 29237092
S446 Phosphorylation PhosphoSitePlus   UniProt 24275569
S452 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S456 O-Glycosylation GlyGen 23301498, 33214551, 35138101, ...34019948, 32574038, 30059200, 35254053, 35132862, 31492838, 35289036, 29237092
S456 Phosphorylation PhosphoSitePlus
T457 Phosphorylation P06493 (CDK1) phospho.ELM   PhosphoSitePlus   Signor 30021153, 18669648
T460 O-Glycosylation GlyGen 23301498, 33214551, 35138101, ...34019948, 32574038, 30059200, 35254053, 35132862, 31492838, 35289036, 29237092
T460 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
T462 Phosphorylation phospho.ELM 18669648
K466 Acetylation PhosphoSitePlus
K466 Ubiquitination PhosphoSitePlus
S470 O-Glycosylation GlyGen 32574038
S470 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
T471 Phosphorylation P06493 (CDK1) phospho.ELM   PhosphoSitePlus   Signor   UniProt 30021153, 18669648, 19690332
S475 O-Glycosylation GlyGen 23301498, 33214551, 35138101, ...34019948, 32574038, 30059200, 35254053, 35132862, 31492838, 35289036, 29237092
S475 Phosphorylation PhosphoSitePlus
S476 Phosphorylation PhosphoSitePlus
T482 Phosphorylation P06493 (CDK1) phospho.ELM   PhosphoSitePlus   Signor 30021153, 16964243
K486 Ubiquitination PhosphoSitePlus
T500 Phosphorylation PhosphoSitePlus
S511 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 17081983
S518 Phosphorylation PhosphoSitePlus
S519 Phosphorylation PhosphoSitePlus
S520 Phosphorylation PhosphoSitePlus
S523 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 19690332, ...24275569
S525 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 23186163, 18220336, 18669648, ...24275569, 19690332
T531 Phosphorylation PhosphoSitePlus
S532 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S534 Phosphorylation phospho.ELM 18669648
S535 Phosphorylation PhosphoSitePlus
S538 Phosphorylation PhosphoSitePlus
T556 Phosphorylation PhosphoSitePlus
K581 Ubiquitination PhosphoSitePlus
C602 Methylation IEDB 31844290
C615 Methylation IEDB 31844290
K634 Ubiquitination PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S53 Phosphorylation HPRD 20068231
S62 Phosphorylation HPRD 20068231, 18452278
S64 Phosphorylation HPRD 19651622, 20068231, 18452278
S72 Phosphorylation HPRD 18452278
T293 Phosphorylation HPRD 19413330, 18669648, 16964243, ...20068231
T295 Phosphorylation HPRD 20068231
T373 Phosphorylation HPRD 20068231
S379 Phosphorylation HPRD 20068231
T395 Phosphorylation HPRD 20068231
S418 Phosphorylation HPRD 20068231
S436 Phosphorylation HPRD 20068231
S446 Phosphorylation HPRD 20068231
S452 Phosphorylation HPRD 18669648
S456 Phosphorylation HPRD 20068231
T457 Phosphorylation HPRD 18669648, 20068231
T460 Phosphorylation HPRD 18669648
T462 Phosphorylation HPRD 18669648
S470 Phosphorylation HPRD 18669648, 20068231
T471 Phosphorylation HPRD 18669648, 20068231
T482 Phosphorylation HPRD 19413330, 16964243, 20068231
S511 Phosphorylation HPRD 19651622, 18669648, 17081983, ...20068231
S523 Phosphorylation HPRD 18669648, 17081983, 18452278
S525 Phosphorylation HPRD 18669648, 17081983, 18452278
S532 Phosphorylation HPRD 18669648, 18452278
S534 Phosphorylation HPRD 18669648
Site PTM Type PTM Enzyme Score Source PMID
S8 Phosphorylation HPRD 20068231
S17 Phosphorylation HPRD 20068231, 18452278
S19 Phosphorylation HPRD 19651622, 20068231, 18452278
S27 Phosphorylation HPRD 18452278
T248 Phosphorylation HPRD 19413330, 18669648, 16964243, ...20068231
T250 Phosphorylation HPRD 20068231
T328 Phosphorylation HPRD 20068231
S334 Phosphorylation HPRD 20068231
T350 Phosphorylation HPRD 20068231
S373 Phosphorylation HPRD 20068231
S391 Phosphorylation HPRD 20068231
S401 Phosphorylation HPRD 20068231
S407 Phosphorylation HPRD 18669648
S411 Phosphorylation HPRD 20068231
T412 Phosphorylation HPRD 18669648, 20068231
T415 Phosphorylation HPRD 18669648
T417 Phosphorylation HPRD 18669648
S425 Phosphorylation HPRD 18669648, 20068231
T426 Phosphorylation HPRD 18669648, 20068231
T437 Phosphorylation HPRD 19413330, 16964243, 20068231
S466 Phosphorylation HPRD 19651622, 18669648, 17081983, ...20068231
S478 Phosphorylation HPRD 18669648, 17081983, 18452278
S480 Phosphorylation HPRD 18669648, 17081983, 18452278
S487 Phosphorylation HPRD 18669648, 18452278
S489 Phosphorylation HPRD 18669648
Site PTM Type PTM Enzyme Score Source PMID
S53 Phosphorylation HPRD 20068231
S62 Phosphorylation HPRD 20068231, 18452278
S64 Phosphorylation HPRD 19651622, 20068231, 18452278
S72 Phosphorylation HPRD 18452278
T270 Phosphorylation HPRD 20068231
S276 Phosphorylation HPRD 20068231
T292 Phosphorylation HPRD 20068231
S315 Phosphorylation HPRD 20068231
S333 Phosphorylation HPRD 20068231
S343 Phosphorylation HPRD 20068231
S349 Phosphorylation HPRD 18669648
S353 Phosphorylation HPRD 20068231
T354 Phosphorylation HPRD 18669648, 20068231
T357 Phosphorylation HPRD 18669648
T359 Phosphorylation HPRD 18669648
S367 Phosphorylation HPRD 18669648, 20068231
T368 Phosphorylation HPRD 18669648, 20068231
T379 Phosphorylation HPRD 19413330, 16964243, 20068231
S408 Phosphorylation HPRD 19651622, 18669648, 17081983, ...20068231
S420 Phosphorylation HPRD 18669648, 17081983, 18452278
S422 Phosphorylation HPRD 18669648, 17081983, 18452278
S429 Phosphorylation HPRD 18669648, 18452278
S431 Phosphorylation HPRD 18669648


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S8 * Biomuta DOID:11054 / urinary bladder cancer [ cosmic ]
S53 * Biomuta DOID:11054 / urinary bladder cancer [ cosmic ]
K144 R144 Biomuta DOID:1324 / lung cancer [ cosmic ]
S180 I180 Biomuta [ cosmic ] DOID:1115 / sarcoma [ icgc ]
Y187 N187 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
T197 S197 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
S265 C265 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
S286 P286 Biomuta DOID:3571 / liver cancer [ cosmic ]
S286 Y286 Biomuta DOID:1319 / brain cancer [ cosmic, icgc ]
S286 C286 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
T287 A287 Biomuta DOID:4159 / skin cancer [ cosmic ]
T292 A292 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
S346 F346 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
T350 A350 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
S351 L351 Biomuta DOID:363 / uterine cancer [ icgc ]
T395 A395 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
S420 C420 Biomuta DOID:4159 / skin cancer [ cosmic ]
S429 Y429 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ] DOID:11054 / urinary bladder cancer [ cosmic ]
S475 L475 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S478 C478 Biomuta DOID:4159 / skin cancer [ cosmic ]
S487 Y487 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
S518 * Biomuta DOID:263 / kidney cancer [ cosmic ]
S523 C523 Biomuta DOID:4159 / skin cancer [ cosmic ]
T531 I531 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
T531 N531 Biomuta DOID:1319 / brain cancer [ cosmic, icgc ]
S532 Y532 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
S538 * Biomuta DOID:8618 / oral cavity cancer [ cosmic ]