iPTMnet Report for Q9BRS2 (RIOK1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9BRS2 / RIOK1_HUMAN
Protein Name Serine/threonine-protein kinase RIO1
Gene Name Name: RIOK1
Synonyms:RIO1;
Organism Homo sapiens (Human)

PRO ID PR:Q9BRS2
DAG View
PRO Name serine/threonine-protein kinase RIO1 (human)
Definition A serine/threonine-protein kinase RIO1 that is encoded in the genome of human.
Short Label hRIOK1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9BRS2 (RIOK1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S21 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 19413330, 17322306, 19664995, ...19651622, 18669648, 19690332, 20068231
S22 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 19413330, 23186163, 19664994, ...19664995, 19651622, 18669648, 19690332, 20068231
S24 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18669648
K81 Ubiquitination PhosphoSitePlus
Y83 Phosphorylation PhosphoSitePlus
S89 Phosphorylation PhosphoSitePlus
R95 Methylation PhosphoSitePlus
S102 Phosphorylation PhosphoSitePlus
T107 Phosphorylation PhosphoSitePlus
K124 Ubiquitination PhosphoSitePlus
T175 Phosphorylation PhosphoSitePlus
S204 Phosphorylation PhosphoSitePlus
K218 Ubiquitination PhosphoSitePlus
Y223 Phosphorylation PhosphoSitePlus
S225 Phosphorylation PhosphoSitePlus
C264 Methylation IEDB 31844290
K299 Ubiquitination PhosphoSitePlus
T410 Phosphorylation PhosphoSitePlus   RLIMS-P 29384474
K411 Methylation PhosphoSitePlus
K426 Methylation PhosphoSitePlus
K426 Ubiquitination PhosphoSitePlus
K438 Ubiquitination PhosphoSitePlus
Y440 Phosphorylation PhosphoSitePlus
K451 Ubiquitination PhosphoSitePlus
Y466 Phosphorylation PhosphoSitePlus
T468 Phosphorylation PhosphoSitePlus
T470 Phosphorylation PhosphoSitePlus
K473 Ubiquitination PhosphoSitePlus
K474 Ubiquitination PhosphoSitePlus
K481 Ubiquitination PhosphoSitePlus
T494 Phosphorylation PhosphoSitePlus
T509 Phosphorylation PhosphoSitePlus
K539 Ubiquitination PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S21 T21 Biomuta DOID:5041 / esophageal cancer [ cosmic ]
S21 P21 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S22 F22 Biomuta DOID:263 / kidney cancer [ cosmic ]
R95 * Biomuta DOID:363 / uterine cancer [ cosmic ] DOID:4159 / skin cancer [ cosmic ]
R95 L95 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
S102 L102 Biomuta DOID:263 / kidney cancer [ cosmic ]
Y223 F223 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ]
T468 A468 Biomuta DOID:3571 / liver cancer [ cosmic ]
K474 E474 Biomuta DOID:3571 / liver cancer [ cosmic ]
T509 S509 Biomuta DOID:3571 / liver cancer [ cosmic ]
T509 I509 Biomuta DOID:363 / uterine cancer [ icgc ]