iPTMnet Report for Q9BQE3 (TUBA1C)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9BQE3 / TBA1C_HUMAN
Protein Name Tubulin alpha-1C chain
Gene Name Name: TUBA1C
Synonyms:TUBA6;
Organism Homo sapiens (Human)

PRO ID PR:Q9BQE3
DAG View
PRO Name tubulin alpha-1C chain (human)
Definition A tubulin alpha-1C chain that is encoded in the genome of human.
Short Label hTUBA1C
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9BQE3 (TUBA1C) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S6 O-Glycosylation GlyGen 16408927, 33214551, 28510447, ...35138101, 30397120, 30796923, 34019948, 29351928, 22121020, 34229054
S6 Phosphorylation PhosphoSitePlus
Y24 Phosphorylation PhosphoSitePlus
S38 O-Glycosylation GlyGen 16408927, 33214551, 28510447, ...35138101, 30397120, 30796923, 34019948, 29351928, 22121020, 34229054
S38 Phosphorylation PhosphoSitePlus
K40 Acetylation PhosphoSitePlus   UniProt 24906155
K40 Ubiquitination PhosphoSitePlus
T41 O-Glycosylation GlyGen 16408927, 33214551, 28510447, ...35138101, 30397120, 30796923, 34019948, 29351928, 22121020, 34229054
T41 Phosphorylation HPRD   PhosphoSitePlus 19007248, 20068231
S48 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18691976, 18491316, 17081983, ...19664994, 19664995, 19007248, 18669648, 18452278, 20068231, 19691289
T51 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18669648, 19007248, 20068231
S54 Phosphorylation PhosphoSitePlus
T56 O-Glycosylation GlyGen 16408927, 33214551, 28510447, ...35138101, 30397120, 30796923, 34019948, 29351928, 22121020, 34229054
T56 Phosphorylation PhosphoSitePlus
K60 Acetylation PhosphoSitePlus
K60 Sumoylation PhosphoSitePlus
K60 Ubiquitination PhosphoSitePlus
T73 Phosphorylation PhosphoSitePlus
T80 O-Glycosylation GlyGen 16408927, 33214551, 28510447, ...35138101, 30397120, 30796923, 34019948, 29351928, 22121020, 34229054
T80 Phosphorylation PhosphoSitePlus
T82 Phosphorylation PhosphoSitePlus
Y83 Phosphorylation PhosphoSitePlus
T94 O-Glycosylation GlyGen 16408927, 33214551, 28510447, ...35138101, 30397120, 30796923, 34019948, 29351928, 22121020, 34229054
T94 Phosphorylation PhosphoSitePlus
K96 Acetylation PhosphoSitePlus
K96 Sumoylation PhosphoSitePlus
K96 Ubiquitination PhosphoSitePlus
Y103 Phosphorylation PhosphoSitePlus
Y108 Phosphorylation PhosphoSitePlus
T109 O-Glycosylation GlyGen 16408927, 33214551, 28510447, ...35138101, 30397120, 30796923, 34019948, 29351928, 22121020, 34229054
T109 Phosphorylation PhosphoSitePlus
K112 Acetylation PhosphoSitePlus
K112 Sumoylation PhosphoSitePlus
K112 Ubiquitination PhosphoSitePlus
K124 Acetylation PhosphoSitePlus
K124 Ubiquitination PhosphoSitePlus
T145 O-Glycosylation GlyGen 16408927, 33214551, 28510447, ...35138101, 30397120, 30796923, 34019948, 29351928, 22121020, 34229054
S147 O-Glycosylation GlyGen 16408927, 33214551, 28510447, ...35138101, 30397120, 30796923, 34019948, 29351928, 22121020, 34229054
S151 Phosphorylation PhosphoSitePlus
S158 Phosphorylation P17252 (PRKCA) PhosphoSitePlus 19406749
Y161 Phosphorylation PhosphoSitePlus
K163 Acetylation PhosphoSitePlus
K163 Methylation PhosphoSitePlus
K163 Ubiquitination PhosphoSitePlus
K164 Ubiquitination PhosphoSitePlus
S165 Phosphorylation P17252 (PRKCA) PhosphoSitePlus 19406749
K166 Ubiquitination PhosphoSitePlus
Y172 Phosphorylation PhosphoSitePlus
Y185 Phosphorylation PhosphoSitePlus
S187 Phosphorylation PhosphoSitePlus
T190 Phosphorylation PhosphoSitePlus
T191 Phosphorylation PhosphoSitePlus
T193 Phosphorylation PhosphoSitePlus
T194 Phosphorylation PhosphoSitePlus
S198 Phosphorylation PhosphoSitePlus
Y210 Phosphorylation PhosphoSitePlus
T223 Phosphorylation PhosphoSitePlus
Y224 Phosphorylation PhosphoSitePlus
T225 O-Glycosylation GlyGen 16408927, 33214551, 28510447, ...35138101, 30397120, 30796923, 34019948, 29351928, 22121020, 34229054
T225 Phosphorylation PhosphoSitePlus
S232 Phosphorylation PhosphoSitePlus
S236 Phosphorylation PhosphoSitePlus
S237 Phosphorylation PhosphoSitePlus
T239 Phosphorylation PhosphoSitePlus
S241 Phosphorylation PhosphoSitePlus
T253 Phosphorylation PhosphoSitePlus
T257 O-Glycosylation GlyGen 16408927, 33214551, 28510447, ...35138101, 30397120, 30796923, 34019948, 29351928, 22121020, 34229054
T257 Phosphorylation PhosphoSitePlus
Y262 Phosphorylation PhosphoSitePlus
T271 O-Glycosylation GlyGen 16408927, 33214551, 28510447, ...35138101, 30397120, 30796923, 34019948, 29351928, 22121020, 34229054
T271 Phosphorylation PhosphoSitePlus
Y272 Phosphorylation PhosphoSitePlus
S277 O-Glycosylation GlyGen 16408927, 33214551, 28510447, ...35138101, 30397120, 30796923, 34019948, 29351928, 22121020, 34229054
S277 Phosphorylation PhosphoSitePlus
K280 Acetylation PhosphoSitePlus
K280 Ubiquitination PhosphoSitePlus
Y282 Phosphorylation PhosphoSitePlus
T287 Phosphorylation PhosphoSitePlus
C295 Methylation IEDB 31844290
K304 Ubiquitination PhosphoSitePlus
K311 Acetylation PhosphoSitePlus
K311 Ubiquitination PhosphoSitePlus
Y312 Phosphorylation PhosphoSitePlus
Y319 Phosphorylation PhosphoSitePlus
K326 Acetylation PhosphoSitePlus
K326 Sumoylation PhosphoSitePlus
K326 Ubiquitination PhosphoSitePlus
T334 O-Glycosylation GlyGen 16408927, 33214551, 28510447, ...35138101, 30397120, 30796923, 34019948, 29351928, 22121020, 34229054
T334 Phosphorylation HPRD   PhosphoSitePlus 19007248, 19691289
K336 Acetylation PhosphoSitePlus
K336 Sumoylation PhosphoSitePlus
K336 Ubiquitination PhosphoSitePlus
T337 Phosphorylation PhosphoSitePlus
K338 Methylation PhosphoSitePlus
K338 Ubiquitination PhosphoSitePlus
T340 O-Glycosylation GlyGen 16408927, 33214551, 28510447, ...35138101, 30397120, 30796923, 34019948, 29351928, 22121020, 34229054
T340 Phosphorylation PhosphoSitePlus
T349 Phosphorylation PhosphoSitePlus
K352 Acetylation PhosphoSitePlus
K352 Sumoylation PhosphoSitePlus
K352 Ubiquitination PhosphoSitePlus
Y357 Phosphorylation HPRD   PhosphoSitePlus 15592455
T361 Phosphorylation PhosphoSitePlus
K370 Acetylation PhosphoSitePlus
K370 Sumoylation PhosphoSitePlus
K370 Ubiquitination PhosphoSitePlus
S379 Phosphorylation PhosphoSitePlus
T381 O-Glycosylation GlyGen 16408927, 33214551, 28510447, ...35138101, 30397120, 30796923, 34019948, 29351928, 22121020, 34229054
T382 O-Glycosylation GlyGen 16408927, 33214551, 28510447, ...35138101, 30397120, 30796923, 34019948, 29351928, 22121020, 34229054
K394 Acetylation PhosphoSitePlus
K394 Sumoylation PhosphoSitePlus
K394 Ubiquitination PhosphoSitePlus
Y399 Phosphorylation PhosphoSitePlus
K401 Acetylation PhosphoSitePlus
K401 Sumoylation PhosphoSitePlus
K401 Ubiquitination PhosphoSitePlus
Y408 Phosphorylation PhosphoSitePlus
S419 O-Glycosylation GlyGen 16408927, 33214551, 28510447, ...35138101, 30397120, 30796923, 34019948, 29351928, 22121020, 34229054
S419 Phosphorylation PhosphoSitePlus
K430 Ubiquitination PhosphoSitePlus
Y432 Phosphorylation PhosphoSitePlus   UniProt 19690332
S439 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 19413330, 18691976, 21406692, ...17081983, 19007248, 18452278, 19651622, 18669648, 19690332, 20068231
Y449 Phosphorylation HPRD   PhosphoSitePlus 15592455


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S48 F48 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
K60 E60 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
T94 P94 Biomuta DOID:4606 / bile duct cancer [ cosmic ]
Y103 C103 Biomuta DOID:1324 / lung cancer [ cosmic ]
S147 Y147 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
Y161 S161 Biomuta DOID:4159 / skin cancer [ cosmic ]
S198 P198 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S277 C277 Biomuta DOID:1324 / lung cancer [ cosmic ]
T349 A349 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
T361 I361 Biomuta DOID:10534 / stomach cancer [ cosmic ]
K430 N430 Biomuta DOID:2394 / ovarian cancer [ cosmic, icgc ]
Y449 C449 Biomuta DOID:2394 / ovarian cancer [ cosmic ]